Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem?

por Dowdy, Steven F.
Publicado 2023

Enhanced generation of iPSCs from older adult human cells by a synthetic five-factor self-replicative RNA

por Yoshioka, Naohisa, Dowdy, Steven F.
Publicado 2017

DNA/RNA heteroduplex oligonucleotides: An unanticipated twist in the delivery of ASOs

por Setten, Ryan L., Dowdy, Steven F.
Publicado 2022

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction

por Gump, Jacob M., June, Ronald K., Dowdy, Steven F.
Publicado 2010

Pathologic Prion Protein Infects Cells by Lipid-Raft Dependent Macropinocytosis

por Wadia, Jehangir S., Schaller, Monica, Williamson, R. Anthony, Dowdy, Steven F.
Publicado 2008

Antitumour effects of PLC-γ1-(SH2)(2)-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells

por Katterle, Y, Brandt, B H, Dowdy, S F, Niggemann, B, Zänker, K S, Dittmar, T
Publicado 2004

Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide

por Snyder, Eric L, Meade, Bryan R, Saenz, Cheryl C, Dowdy, Steven F
Publicado 2004

Synthesis of a pH-Sensitive Nitrilotriacetic Linker to Peptide Transduction Domains To Enable Intracellular Delivery of Histidine Imidazole Ring-Containing Macromolecules

por June, Ronald K., Gogoi, Khirud, Eguchi, Akiko, Cui, Xian-Shu, Dowdy, Steven F.
Publicado 2010

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

por Narasimha, Anil M, Kaulich, Manuel, Shapiro, Gary S, Choi, Yoon J, Sicinski, Piotr, Dowdy, Steven F
Publicado 2014

Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi

por Kaulich, Manuel, Lee, Yeon J., Lönn, Peter, Springer, Aaron D., Meade, Bryan R., Dowdy, Steven F.
Publicado 2015

Efficient siRNA Delivery into Primary Cells by Peptide Transduction-dsRNA Binding Domain (PTD-DRBD) Fusion Protein

por Eguchi, Akiko, Meade, Bryan R., Chang, Yung-Chi, Fredrickson, Criag T., Willert, Karl, Puri, Nitin, Dowdy, Steven F.
Publicado 2009

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

por Lönn, Peter, Kacsinta, Apollo D., Cui, Xian-Shu, Hamil, Alexander S., Kaulich, Manuel, Gogoi, Khirud, Dowdy, Steven F.
Publicado 2016

Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients

por Goroshchuk, Oksana, Vidarsdottir, Linda, Björklund, Ann-Charlotte, Hamil, Alexander S., Kolosenko, Iryna, Dowdy, Steven F., Palm-Apergi, Caroline
Publicado 2020

Whi5 Regulation by Site Specific CDK-Phosphorylation in Saccharomyces cerevisiae

por Wagner, Michelle V., Smolka, Marcus B., de Bruin, Rob A. M., Zhou, Huilin, Wittenberg, Curt, Dowdy, Steven F.
Publicado 2009

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

por Huggins, Ian J., Medina, Carlos A., Springer, Aaron D., van den Berg, Arjen, Jadhav, Satish, Cui, Xianshu, Dowdy, Steven F.
Publicado 2019

A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition

por Kaulich, Manuel, Link, Verena M., Lapek, John D., Lee, Yeon J., Glass, Christopher K., Gonzalez, David J., Dowdy, Steven F.
Publicado 2021

Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation

por Khan, Nabab, Halcrow, Peter W., Lakpa, Koffi L., Afghah, Zahra, Miller, Nicole M., Dowdy, Steven F., Geiger, Jonathan D., Chen, Xuesong
Publicado 2020

A systems biology dynamical model of mammalian G(1) cell cycle progression

por Haberichter, Thomas, Mädge, Britta, Christopher, Renee A, Yoshioka, Naohisa, Dhiman, Anjali, Miller, Robert, Gendelman, Rina, Aksenov, Sergej V, Khalil, Iya G, Dowdy, Steven F
Publicado 2007

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

por Meitinger, Franz, Anzola, John V., Kaulich, Manuel, Richardson, Amelia, Stender, Joshua D., Benner, Christopher, Glass, Christopher K., Dowdy, Steven F., Desai, Arshad, Shiau, Andrew K., Oegema, Karen
Publicado 2016

Reversing Parkinson Disease Model with in situ Converted Nigral Neurons

por Qian, Hao, Kang, Xinjiang, Hu, Jing, Zhang, Dongyang, Liang, Zhengyu, Meng, Fan, Zhang, Xuan, Xue, Yuanchao, Maimon, Roy, Dowdy, Steven F., Devaraj, Neal K., Zhou, Zhuan, Mobley, William C., Cleveland, Don W., Fu, Xiang-Dong
Publicado 2020