Targeting the Sphingolipid Rheostat in Gliomas

por Zaibaq, Faris, Dowdy, Tyrone, Larion, Mioara
Publicado 2022

DDRE-20. TARGETING SPHINGOLIPID PATHWAY REVEALS VULNERABILITY IN IDH1(MUT) GLIOMA

por Dowdy, Tyrone, Zhang, Lumin, Celiku, Orieta, Movva, Sriya, Ruiz-Rodado, Victor, Lita, Adrian, Larion, Mioara
Publicado 2021

BIMG-10. IDH1 MUTATIONS INDUCE ORGANELLE DEFECTS VIA DYSREGULATED PHOSPHOLIPIDS

por Yamasaki, Tomohiro, Lita, Adrian, Zhang, Lumin, Rodado, Victor Ruiz, Dowdy, Tyrone, Gilbert, Mark, Larion, Mioara
Publicado 2021

OTME-4. IDH mutated gliomas promote epileptogenesis via D-2-hydroxyglutarate dependent mTOR hyperactivation

por Mortazavi, Armin, Fayed, Islam, Bachani, Muzna, Maric, Dragan, Dowdy, Tyrone, Larion, Mioara, Ksendzovsky, Alexander, Zaghloul, Kareem
Publicado 2021

Sphingolipid Pathway as a Source of Vulnerability in IDH1(mut) Glioma

por Dowdy, Tyrone, Zhang, Lumin, Celiku, Orieta, Movva, Sriya, Lita, Adrian, Ruiz-Rodado, Victor, Gilbert, Mark R., Larion, Mioara
Publicado 2020

DDRE-16. CYSTEINE IS AN ESSENTIAL AMINO ACID IN GLIOMAS

por Ruiz-Rodado, Victor, Dowdy, Tyrone, Yung, Jinkyu, Dios-Esponera, Ana, Lita, Adrian, Kramp, Tamalee, Camphausen, Kevin, Gilbert, Mark, Larion, Mioara
Publicado 2021

CBMS-5 STEAROYL-COA DESATURASE INHIBITOR INDUCES APOPTOSIS VIA ENHANCING LIPOLYSIS IN IDH MUTANT GLIOMA

por Zhang, Lumin, Zhang, Lumin, Dowdy, Tyrone, Lita, Adrian, Suzuki, Ryoichi, Kida, Satoru, Ooishi, Tomoya, Koizumi, Shinichiro, Kurozumi, Kazuhiko, Larion, Mioara
Publicado 2022

Detection of Metabolic Changes Induced via Drug Treatments in Live Cancer Cells and Tissue Using Raman Imaging Microscopy

por Larion, Mioara, Dowdy, Tyrone, Ruiz-Rodado, Victor, Meyer, Matthew W., Song, Hua, Zhang, Wei, Davis, Dionne, Gilbert, Mark R., Lita, Adrian
Publicado 2018

DDRE-27. IDH MUTATED GLIOMAS PROMOTE EPILEPTOGENESIS VIA D-2-HYDROXYGLUTARATE DEPENDENT MTOR HYPERACTIVATION

por Mortazavi, Armin, Fayed, Islam, Bachani, Muzna, Dowdy, Tyrone, Steiner, Joseph, Maric, Dragan, Yang, Chun Zhang, Larion, Mioara, Ksendzovsky, Alexander, Zaghloul, Kareem
Publicado 2021

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis

por Cheema, Amrita K., Maier, Irene, Dowdy, Tyrone, Wang, Yiwen, Singh, Rajbir, Ruegger, Paul M., Borneman, James, Fornace, Albert J., Schiestl, Robert H.
Publicado 2016

Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma

por Ruiz-Rodado, Victor, Seki, Tomohiro, Dowdy, Tyrone, Lita, Adrian, Zhang, Meili, Han, Sue, Yang, Chunzhang, Cherukuri, Murali K., Gilbert, Mark R., Larion, Mioara
Publicado 2020

Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse model

por Ruiz-Rodado, Victor, Dowdy, Tyrone, Lita, Adrian, Kramp, Tamalee, Zhang, Meili, Shuboni-Mulligan, Dorela, Herold-Mende, Christel, Armstrong, Terri S., Gilbert, Mark R., Camphausen, Kevin, Larion, Mioara
Publicado 2022

Cysteine is a limiting factor for glioma proliferation and survival

por Ruiz‐Rodado, Victor, Dowdy, Tyrone, Lita, Adrian, Kramp, Tamalee, Zhang, Meili, Jung, Jinkyu, Dios‐Esponera, Ana, Zhang, Lumin, Herold‐Mende, Christel C., Camphausen, Kevin, Gilbert, Mark R., Larion, Mioara
Publicado 2022

Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)

por Haymond, Amanda, Johny, Chinchu, Dowdy, Tyrone, Schweibenz, Brandon, Villarroel, Karen, Young, Richard, Mantooth, Clark J., Patel, Trishal, Bases, Jessica, Jose, Geraldine San, Jackson, Emily R., Dowd, Cynthia S., Couch, Robin D.
Publicado 2014

Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis

por Altadill, Tatiana, Dowdy, Tyrone M., Gill, Kirandeep, Reques, Armando, Menon, Smrithi S., Moiola, Cristian P., Lopez-Gil, Carlos, Coll, Eva, Matias-Guiu, Xavier, Cabrera, Silvia, Garcia, Angel, Reventos, Jaume, Byers, Stephen W., Gil-Moreno, Antonio, Cheema, Amrita K., Colas, Eva
Publicado 2017

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies

por Ratnam, Nivedita M., Sonnemann, Heather M., Frederico, Stephen C., Chen, Huanwen, Hutchinson, Marsha-Kay N. D., Dowdy, Tyrone, Reid, Caitlin M., Jung, Jinkyu, Zhang, Wei, Song, Hua, Zhang, Meili, Davis, Dionne, Larion, Mioara, Giles, Amber J., Gilbert, Mark R.
Publicado 2021

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

por Ruiz-Rodado, Victor, Lita, Adrian, Dowdy, Tyrone, Celiku, Orieta, Saldana, Alejandra Cavazos, Wang, Herui, Yang, Chun Zhang, Chari, Raj, Li, Aiguo, Zhang, Wei, Song, Hua, Zhang, Meili, Ahn, Susie, Davis, Dionne, Chen, Xiang, Zhuang, Zhengping, Herold-Mende, Christel, Walters, Kylie J., Gilbert, Mark R., Larion, Mioara
Publicado 2020

IDH1 mutations induce organelle defects via dysregulated phospholipids

por Lita, Adrian, Pliss, Artem, Kuzmin, Andrey, Yamasaki, Tomohiro, Zhang, Lumin, Dowdy, Tyrone, Burks, Christina, de Val, Natalia, Celiku, Orieta, Ruiz-Rodado, Victor, Nicoli, Elena-Raluca, Kruhlak, Michael, Andresson, Thorkell, Das, Sudipto, Yang, Chunzhang, Schmitt, Rebecca, Herold-Mende, Christel, Gilbert, Mark R., Prasad, Paras N., Larion, Mioara
Publicado 2021