The convergent total synthesis and antibacterial profile of the natural product streptothricin F

por Dowgiallo, Matthew G., Miller, Brandon C., Kassu, Mintesinot, Smith, Kenneth P., Fetigan, Andrew D., Guo, Jason J., Kirby, James E., Manetsch, Roman
Publicado 2022

Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome

por Morgan, Christopher E., Kang, Yoon-Suk, Green, Alex B., Smith, Kenneth P., Dowgiallo, Matthew G., Miller, Brandon C., Chiaraviglio, Lucius, Truelson, Katherine A., Zulauf, Katelyn E., Rodriguez, Shade, Kang, Anthony D., Manetsch, Roman, Yu, Edward W., Kirby, James E.
Publicado 2023

Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases

por Kassu, Mintesinot, Parvatkar, Prakash T., Milanes, Jillian, Monaghan, Neil P., Kim, Chungsik, Dowgiallo, Matthew, Zhao, Yingzhao, Asakawa, Ami H., Huang, Lili, Wagner, Alicia, Miller, Brandon, Carter, Karissa, Barrett, Kayleigh F., Tillery, Logan M., Barrett, Lynn K., Phan, Isabelle Q., Subramanian, Sandhya, Myler, Peter J., Van Voorhis, Wesley C., Leahy, James W., Rice, Christopher A., Kyle, Dennis E., Morris, James, Manetsch, Roman
Publicado 2023