Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans

por Steyer, Joel T., Downes, Damien J., Hunter, Cameron C., Migeon, Pierre A., Todd, Richard B.
Publicado 2021

Multi Locus View: an extensible web-based tool for the analysis of genomic data.

por Sergeant, Martin J., Hughes, Jim R., Hentges, Lance, Lunter, Gerton, Downes, Damien J., Taylor, Stephen
Publicado 2021

Characterization of the Mutagenic Spectrum of 4-Nitroquinoline 1-Oxide (4-NQO) in Aspergillus nidulans by Whole Genome Sequencing

por Downes, Damien J., Chonofsky, Mark, Tan, Kaeling, Pfannenstiel, Brandon T., Reck-Peterson, Samara L., Todd, Richard B.
Publicado 2014

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C

por Oudelaar, A. Marieke, Davies, James O.J., Downes, Damien J., Higgs, Douglas R., Hughes, Jim R.
Publicado 2017

LanceOtron: a deep learning peak caller for genome sequencing experiments

por Hentges, Lance D, Sergeant, Martin J, Cole, Christopher B, Downes, Damien J, Hughes, Jim R, Taylor, Stephen
Publicado 2022

High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates

por Nussbaum, Lea, Telenius, Jelena M., Hill, Stephanie, Hirschfeld, Priscila P., Suciu, Maria C., Downes, Damien J., Hughes, Jim R.
Publicado 2018

DeepC: predicting 3D genome folding using megabase-scale transfer learning

por Schwessinger, Ron, Gosden, Matthew, Downes, Damien, Brown, Richard C, Oudelaar, A. Marieke, Telenius, Jelena, Teh, Yee Whye, Lunter, Gerton, Hughes, Jim R.
Publicado 2020

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells

por Torres, Jason M., Sun, Han, Nylander, Vibe, Downes, Damien J., van de Bunt, Martijn, McCarthy, Mark I., Hughes, Jim R., Gloyn, Anna L.
Publicado 2023

Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

por Simon, Claire S., Downes, Damien J., Gosden, Matthew E., Telenius, Jelena, Higgs, Douglas R., Hughes, Jim R., Costello, Ita, Bikoff, Elizabeth K., Robertson, Elizabeth J.
Publicado 2017

Impaired DNA demethylation of C/EBP sites causes premature aging

por Schäfer, Andrea, Mekker, Bernadette, Mallick, Medhavi, Vastolo, Viviana, Karaulanov, Emil, Sebastian, Dominik, von der Lippen, Carina, Epe, Bernd, Downes, Damien J., Scholz, Carola, Niehrs, Christof
Publicado 2018

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

por Bozhilov, Yavor K., Downes, Damien J., Telenius, Jelena, Marieke Oudelaar, A., Olivier, Emmanuel N., Mountford, Joanne C., Hughes, Jim R., Gibbons, Richard J., Higgs, Douglas R.
Publicado 2021

Spatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization

por Benoit, Isabelle, Zhou, Miaomiao, Vivas Duarte, Alexandra, Downes, Damien J., Todd, Richard B., Kloezen, Wendy, Post, Harm, Heck, Albert J. R., Maarten Altelaar, A. F., de Vries, Ronald P.
Publicado 2015

Capture-C: A modular and flexible approach for high-resolution chromosome conformation capture

por Downes, Damien J., Smith, Alastair L., Karpinska, Magdalena A., Velychko, Taras, Rue-Albrecht, Kevin, Sims, David, Milne, Thomas A., Davies, James O.J., Oudelaar, A. Marieke, Hughes, Jim R.
Publicado 2022

Tissue-specific CTCF/Cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

por Hanssen, Lars L P, Kassouf, Mira T, Oudelaar, A Marieke, Biggs, Daniel, Preece, Chris, Downes, Damien J, Gosden, Matthew, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Hughes, Jim R, Davies, Benjamin, Higgs, Douglas R
Publicado 2017

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

por Godfrey, Laura, Crump, Nicholas T., Thorne, Ross, Lau, I-Jun, Repapi, Emmanouela, Dimou, Dimitra, Smith, Alastair L., Harman, Joe R., Telenius, Jelena M., Oudelaar, A. Marieke, Downes, Damien J., Vyas, Paresh, Hughes, Jim R., Milne, Thomas A.
Publicado 2019

The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

por Truch, Julia, Downes, Damien J., Scott, Caroline, Gür, E. Ravza, Telenius, Jelena M., Repapi, Emmanouela, Schwessinger, Ron, Gosden, Matthew, Brown, Jill M., Taylor, Stephen, Cheong, Pak Leng, Hughes, Jim R., Higgs, Douglas R., Gibbons, Richard J.
Publicado 2022

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

por Owens, Dominic D. G., Anselmi, Giorgio, Oudelaar, A. Marieke, Downes, Damien J., Cavallo, Alessandro, Harman, Joe R., Schwessinger, Ron, Bucakci, Akin, Greder, Lucas, de Ornellas, Sara, Jeziorska, Danuta, Telenius, Jelena, Hughes, Jim R., de Bruijn, Marella F. T. R.
Publicado 2022

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains

por Oudelaar, A. Marieke, Davies, James O.J., Hanssen, Lars L.P., Telenius, Jelena M., Schwessinger, Ron, Liu, Yu, Brown, Jill M., Downes, Damien J., Chiariello, Andrea M., Bianco, Simona, Nicodemi, Mario, Buckle, Veronica J., Dekker, Job, Higgs, Douglas R., Hughes, Jim R.
Publicado 2018

Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers

por Bejjani, Fabienne, Tolza, Claire, Boulanger, Mathias, Downes, Damien, Romero, Raphaël, Maqbool, Muhammad Ahmad, Zine El Aabidine, Amal, Andrau, Jean-Christophe, Lebre, Sophie, Brehelin, Laurent, Parrinello, Hughes, Rohmer, Marine, Kaoma, Tony, Vallar, Laurent, Hughes, Jim R, Zibara, Kazem, Lecellier, Charles-Henri, Piechaczyk, Marc, Jariel-Encontre, Isabelle
Publicado 2021

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

por Mettananda, Sachith, Fisher, Chris A., Hay, Deborah, Badat, Mohsin, Quek, Lynn, Clark, Kevin, Hublitz, Philip, Downes, Damien, Kerry, Jon, Gosden, Matthew, Telenius, Jelena, Sloane-Stanley, Jackie A., Faustino, Paula, Coelho, Andreia, Doondeea, Jessica, Usukhbayar, Batchimeg, Sopp, Paul, Sharpe, Jacqueline A., Hughes, Jim R., Vyas, Paresh, Gibbons, Richard J., Higgs, Douglas R.
Publicado 2017