Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

por Lee, Youngsoo, Katyal, Sachin, Downing, Susanna M., Zhao, Jingfeng, Russell, Helen R., McKinnon, Peter J.
Publicado 2012

Aberrant Topoisomerase-1-DNA Lesions are Pathogenic in Neurodegenerative Genome Instability Syndromes

por Katyal, Sachin, Lee, Youngsoo, Nitiss, Karin C., Downing, Susanna M., Li, Yang, Shimada, Mikio, Zhao, Jingfeng, Russell, Helen R., Petrini, John H. J., Nitiss, John L., McKinnon, Peter J.
Publicado 2014

Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice

por Machado, Eda R., van de Vlekkert, Diantha, Sheppard, Heather S., Perry, Scott, Downing, Susanna M., Laxton, Jonathan, Ashmun, Richard, Finkelstein, David B., Neale, Geoffrey A., Hu, Huimin, Harwood, Frank C., Koo, Selene C., Grosveld, Gerard C., d’Azzo, Alessandra
Publicado 2022

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

por Ratnaparkhe, Manasi, Wong, John K. L., Wei, Pei-Chi, Hlevnjak, Mario, Kolb, Thorsten, Simovic, Milena, Haag, Daniel, Paul, Yashna, Devens, Frauke, Northcott, Paul, Jones, David T. W., Kool, Marcel, Jauch, Anna, Pastorczak, Agata, Mlynarski, Wojciech, Korshunov, Andrey, Kumar, Rajiv, Downing, Susanna M., Pfister, Stefan M., Zapatka, Marc, McKinnon, Peter J., Alt, Frederick W., Lichter, Peter, Ernst, Aurélie
Publicado 2018