Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila

por Zhu, Jun-yi, Hannan, Shabab B., Dräger, Nina M., Vereshchagina, Natalia, Krahl, Ann-Christin, Fu, Yulong, Elliott, Christopher J.H., Han, Zhe, Jahn, Thomas R., Rasse, Tobias M.
Publicado 2021

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology

por de Majo, Martina, Koontz, Mark, Marsan, Elise, Salinas, Nir, Ramsey, Arren, Kuo, Yien-Ming, Seo, Kyounghee, Li, Huinan, Dräger, Nina, Leng, Kun, Gonzales, Santiago L., Kurnellas, Michael, Miyaoka, Yuichiro, Klim, Joseph R., Kampmann, Martin, Ward, Michael E., Huang, Eric J., Ullian, Erik M.
Publicado 2023

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

por Dräger, Nina M., Sattler, Sydney M., Huang, Cindy Tzu-Ling, Teter, Olivia M., Leng, Kun, Hashemi, Sayed Hadi, Hong, Jason, Aviles, Giovanni, Clelland, Claire D., Zhan, Lihong, Udeochu, Joe C., Kodama, Lay, Singleton, Andrew B., Nalls, Mike A., Ichida, Justin, Ward, Michael E., Faghri, Faraz, Gan, Li, Kampmann, Martin
Publicado 2022

MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state

por You, Shih-Feng, Brase, Logan, Filipello, Fabia, Iyer, Abhirami K., Del-Aguila, Jorge, He, June, D’Oliveira Albanus, Ricardo, Budde, John, Norton, Joanne, Gentsch, Jen, Dräger, Nina M., Sattler, Sydney M., Kampmann, Martin, Piccio, Laura, Morris, John C., Perrin, Richard J., McDade, Eric, Paul, Steven M., Cashikar, Anil G., Benitez, Bruno A., Harari, Oscar, Karch, Celeste M.
Publicado 2023