Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites

por Kamaraj, Rajamanikkam, Drastik, Martin, Maixnerova, Jana, Pavek, Petr
Publicado 2022

(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimu...

por Stefela, Alzbeta, Kaspar, Miroslav, Drastik, Martin, Kronenberger, Thales, Micuda, Stanislav, Dracinsky, Martin, Klepetarova, Blanka, Kudova, Eva, Pavek, Petr
Publicado 2021

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain

por Skoda, Josef, Dusek, Jan, Drastik, Martin, Stefela, Alzbeta, Dohnalova, Klara, Chalupsky, Karel, Smutny, Tomas, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Publicado 2020