Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

por Drewry, David H., Willson, Timothy M., Zuercher, William J.
Publicado 2014

Targeting the Divergent Roles of STK3 Inhibits Breast Cancer Cell Growth and Opposes Doxorubicin-Induced Cardiotoxicity In Vitro

por Nam, Jiung, Schirmer, Amelia U., Loh, Chelsea, Drewry, David H., Macias, Everardo
Publicado 2023

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

por Tamir, Tigist Y., Drewry, David H., Wells, Carrow, Major, M. Ben, Axtman, Alison D.
Publicado 2020

Host-directed therapy, an untapped opportunity for antimalarial intervention

por Wei, Ling, Adderley, Jack, Leroy, Didier, Drewry, David H., Wilson, Danny W., Kaushansky, Alexis, Doerig, Christian
Publicado 2021

How many kinases are druggable? A review of our current understanding

por Anderson, Brian, Rosston, Peter, Ong, Han Wee, Hossain, Mohammad Anwar, Davis-Gilbert, Zachary W., Drewry, David H.
Publicado 2023

Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays

por Dranchak, Patricia, MacArthur, Ryan, Guha, Rajarshi, Zuercher, William J., Drewry, David H., Auld, Douglas S., Inglese, James
Publicado 2013

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

por Schröder, Martin, Filippakopoulos, Panagis, Schwalm, Martin P., Ferrer, Carla A., Drewry, David H., Knapp, Stefan, Chaikuad, Apirat
Publicado 2020

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA

por Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Striker, Rob, Sauer, John-Demian
Publicado 2017

HighVia—A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity

por Howarth, Alison, Schröder, Martin, Montenegro, Raquel C., Drewry, David H., Sailem, Heba, Millar, Val, Müller, Susanne, Ebner, Daniel V.
Publicado 2020

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration

por Drewry, David H., Annor-Gyamfi, Joel K., Wells, Carrow I., Pickett, Julie E., Dederer, Verena, Preuss, Franziska, Mathea, Sebastian, Axtman, Alison D.
Publicado 2021

Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment

por Nguyen, Khoa, Rivera, Andrew, Alzoubi, Madlin, Wathieu, Henri, Dong, Shengli, Yousefi, Hassan, Matossian, Margarite, Alahari, Suresh, Drewry, David, Burow, Matthew, Collins-Burow, Bridgette
Publicado 2021

NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

por Nguyen, Khoa, Boehling, Julia, Tran, Minh N., Cheng, Thomas, Rivera, Andrew, Collins-Burow, Bridgette M., Lee, Sean B., Drewry, David H., Burow, Matthew E.
Publicado 2023

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

por Bashore, Frances M., Marquez, Ariana B., Chaikuad, Apirat, Howell, Stefanie, Dunn, Andrea S., Beltran, Alvaro A., Smith, Jeffery L., Drewry, David H., Beltran, Adriana S., Axtman, Alison D.
Publicado 2023

Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

por Eberl, H. Christian, Werner, Thilo, Reinhard, Friedrich B., Lehmann, Stephanie, Thomson, Douglas, Chen, Peiling, Zhang, Cunyu, Rau, Christina, Muelbaier, Marcel, Drewes, Gerard, Drewry, David, Bantscheff, Marcus
Publicado 2019

Development and Comparison of Complementary Methods to Study Potential Skin and Inhalational Exposure to Pathogens During Personal Protective Equipment Doffing

por Therkorn, Jennifer, Drewry, David, Andonian, Jennifer, Benishek, Lauren, Billman, Carrie, Forsyth, Ellen R, Garibaldi, Brian T, Nowakowski, Elaine, Rainwater-Lovett, Kaitlin, Sauer, Lauren, Schiffhauer, Maggie, Maragakis, Lisa L
Publicado 2019

Synergistic drug combinations and machine learning for drug repurposing in chordoma

por Anderson, Edward, Havener, Tammy M., Zorn, Kimberley M., Foil, Daniel H., Lane, Thomas R., Capuzzi, Stephen J., Morris, Dave, Hickey, Anthony J., Drewry, David H., Ekins, Sean
Publicado 2020

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

por Byrne, Dominic P., Li, Yong, Ngamlert, Pawin, Ramakrishnan, Krithika, Eyers, Claire E., Wells, Carrow, Drewry, David H., Zuercher, William J., Berry, Neil G., Fernig, David G., Eyers, Patrick A.
Publicado 2018

Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast c...

por Matossian, Margarite D., Elliott, Steven, Rhodes, Lyndsay V., Martin, Elizabeth C., Hoang, Van T., Burks, Hope E., Zuercher, William J., Drewry, David H., Collins-Burow, Bridgette M., Burow, Matthew E.
Publicado 2021

Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors

por Kalogirou, Andreas S., East, Michael P., Laitinen, Tuomo, Torrice, Chad D., Maffuid, Kaitlyn A., Drewry, David H., Koutentis, Panayiotis A., Johnson, Gary L., Crona, Daniel J., Asquith, Christopher R. M.
Publicado 2021

Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes

por Matossian, Margarite D., Elliott, Steven, Hoang, Van T., Burks, Hope E., Phamduy, Theresa B., Chrisey, Douglas B., Zuercher, William J., Drewry, David H., Wells, Carrow, Collins-Burow, Bridgette, Burow, Matthew E.
Publicado 2017