DIPG-06. PRECLINICAL EVALUATION OF A NOVEL ACVR1 INHIBITOR IN DIFFUSE INTRINSIC PONTINE GLIOMAS

por Kumar, Shiva Senthil, Shoffner, Rebecca, Devine, Brendan, Drissi, Rachid
Publicado 2023

Alternative Lengthening of Telomeres in Pediatric High-Grade Glioma and Therapeutic Implications

por Umaru, Banlanjo, Sengupta, Satarupa, Senthil Kumar, Shiva, Drissi, Rachid
Publicado 2023

DIPG-05. EVALUATION OF TELOMERE-MODIFYING COMPOUND THIO AS A RADIOSENSITIZER AND IMMUNOMODULATOR TO TREAT DIPG

por Mishra, Deepak, Umaru, Banlanjo, Kumar, Shiva Senthil, Gryaznov, Sergei, Drissi, Rachid
Publicado 2023

DIPG-07. ROBUST CGAS-STING PATHWAY MEDIATED-INDUCTION OF ANTITUMOR ADAPTIVE IMMUNE RESPONSE: A POTENTIAL FOR DMG IMMUNOTHERAPY

por Umaru, Banlanjo, Mishra, Deepak, Kumar, Shiva Senthil, Devine, Brendan, Drissi, Rachid
Publicado 2023

Limitations of radiosensitization by direct telomerase inhibition to treat high-risk medulloblastoma

por Sengupta, Satarupa, Senthil Kumar, Shiva, Bondra, Kathryn, Sobo, Matthew, Mo, Xiaokui, Drissi, Rachid
Publicado 2023

DIPG-21. INDUCTION OF MITOTIC ABNORMALITIES AND BMI-1 MODULATION TO TREAT DIFFUSE INTRINSIC PONTINE GLIOMA

por Kumar, Shiva Senthil, Sengupta, Satarupa, Zhu, Xiaoting, Mishra, Deepak Kumar, Fuller, Christine, Fouladi, Maryam, Drissi, Rachid
Publicado 2020

DIPG-16. Evaluation of myeloid component of DIPG microenvironment

por Mishra, Deepak, Rajendran, Sakthi, Zhu, Xiaoting, Nazzaro, Matthew, Kumar, Shiva Senthil, Mchugh, Todd, Rajappa, Prajwal, Drissi, Rachid
Publicado 2022

IMMU-11. PRECLINICAL HIGH-RISK PEDIATRIC BRAIN TUMOR MODELS FOR IMMUNOTHERAPY: HURDLES AND THE WAY FORWARD

por Mishra, Deepak, Morris, Shelli, Popovsk, Dean, Bondoc, Andrew, Kumar, Shiva Senthil, Rutka, James, Huang, Annie, Olson, Jim, Fouladi, Maryam, Drissi, Rachid
Publicado 2023

BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma

por Kumar, Shiva Senthil, Sengupta, Satarupa, Lee, Kyungwoo, Hura, Nanki, Fuller, Christine, DeWire, Mariko, Stevenson, Charles B., Fouladi, Maryam, Drissi, Rachid
Publicado 2017

DIPG-11. DIPGs show robust MHC class I expression but low lymphoid and high myeloid infiltration partly reversible by DNA methyltransferase inhibition

por Mishra, Deepak, Wang, Jie, Chen, Chun-Yu, Zhu, Xiaoting, Kumar, Shiva Senthil, McHugh, Todd, Cripe, Timothy, Fouladi, Maryam, Drissi, Rachid
Publicado 2022

DIPG-51. ABDOMINAL METASTASES OF DIFFUSE MIDLINE GLIOMA, H3K27-ALTERED WITH A VENTRICULOPERITONEAL SHUNT

por Lazow, Margot, Schieffer, Kathleen, Palmer, Joshua, Salloum, Ralph, Widemeyer, Michelle, Sribnick, Eric, Kumar, Shiva Senthil, Umaru, Banlanjo, Drissi, Rachid, Mardis, Elaine, Boué, Daniel, Fouladi, Maryam, Thomas, Diana
Publicado 2023

A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets

por Zhu, Xiaoting, Lazow, Margot A., Schafer, Austin, Bartlett, Allison, Senthil Kumar, Shiva, Mishra, Deepak Kumar, Dexheimer, Phillip, DeWire, Mariko, Fuller, Christine, Leach, James L., Fouladi, Maryam, Drissi, Rachid
Publicado 2021

DIPG-52. EXTRAPONTINE PROGRESSION WITH STABLE PONTINE DISEASE POST-RADIOTHERAPY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) ON A CONNECT TRIAL: IMPLICATIONS FOR RADIATION TREATMENT...

por Lazow, Margot, Palmer, Joshua, Stanek, Joseph, Baxter, Patricia, Thomas, Diana, Salloum, Ralph, de Blank, Peter, Mikael, Leonie, Kumar, Shiva Senthil, Leonard, Jeffrey, Mardis, Elaine, Drissi, Rachid, Fouladi, Maryam, Rodriguez, Diana
Publicado 2023

EPCT-16. A PHASE IB STUDY OF PTC596 IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA AND HIGH GRADE GLIOMA

por Smiley, Natasha Pillay, Baxter, Patricia, Kumar, Shiva, Hwang, Eugene, Breneman, John, Lane, Adam, Doughman, Renee, Deutsch, Michelle, Stevenson, Charles, Stewart, Clinton, Leach, Jim, Li, Xiao-Nan, Romero, Sonia, Maliakal, Pius, Gao, Lan, Fouladi, Maryam, Drissi, Rachid
Publicado 2020

EPCT-19. A PHASE I STUDY OF RIBOCICLIB AND EVEROLIMUS FOLLOWING RADIATION THERAPY IN CHILDREN WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG...

por DeWire, Mariko, Leach, James, Fuller, Christine, de Blank, Peter, Hummel, Trent, Pillay-Smiley, Natasha, Salloum, Ralph, Stevenson, Charles, Drissi, Rachid, Kumar, Shiva Senthil, Baxter, Patricia, Gass, David, Goldman, Stewart, Leary, Sarah, Lane, Adam, Campagne, Olivia, Stewart, Clinton, Fouladi, Maryam
Publicado 2020

The human DEK oncogene regulates DNA damage response signaling and repair

por Kavanaugh, Gina M., Wise-Draper, Trisha M., Morreale, Richard J., Morrison, Monique A., Gole, Boris, Schwemberger, Sandy, Tichy, Elisia D., Lu, Lu, Babcock, George F., Wells, James M., Drissi, Rachid, Bissler, John J., Stambrook, Peter J., Andreassen, Paul R., Wiesmüller, Lisa, Wells, Susanne I.
Publicado 2011

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

por Hoffman, Lindsey M., DeWire, Mariko, Ryall, Scott, Buczkowicz, Pawel, Leach, James, Miles, Lili, Ramani, Arun, Brudno, Michael, Kumar, Shiva Senthil, Drissi, Rachid, Dexheimer, Phillip, Salloum, Ralph, Chow, Lionel, Hummel, Trent, Stevenson, Charles, Lu, Q. Richard, Jones, Blaise, Witte, David, Aronow, Bruce, Hawkins, Cynthia E., Fouladi, Maryam
Publicado 2016

Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

por Hoffman, Lindsey M., DeWire, Mariko, Ryall, Scott, Buczkowicz, Pawel, Leach, James, Miles, Lili, Ramani, Arun K., Brudno, Michael, Kumar, Shiva Senthil, Drissi, Rachid, Dexheimer, Phillip, Salloum, Ralph, Chow, Lionel, Hummel, Trent, Stevenson, Charles, Lu, Q. Richard, Jones, Blaise, Witte, David, Aronow, Bruce, Hawkins, Cynthia E., Fouladi, Maryam
Publicado 2016

DIPG-29. A CONNECT CONSORTIUM PRECLINICAL STUDY IDENTIFIES MEK INHIBITION AND RADIATION AS POTENTIAL COMBINATION PARTNERS FOR THE ALK2 INHIBITOR TP-0184 IN ACVR1-MUTANT DMG

por Rogers, Rebecca, Tsoli, Maria, Kumar, Shiva Senthil, Potente, Elisabet Fernandez, Biery, Matt, Grabovska, Yura, Mackay, Alan, Carvalho, Diana, Pereria, Rita, Burford, Anna, Sejdiu, Drenusha, Ruddle, Ruth, Gabel, Florian, Raynaud, Florence, Yadavilli, Sridevi, Mizoguchi, Sean, Subramaniam, Bavani, Kilburn, Lindsey, Hwang, Eugene, Nazarian, Javad, Vitanza, Nicholas, Ziegler, David, Drissi, Rachid, Jones, Chris
Publicado 2023

EPCT-06. Phase I study of ribociclib and everolimus post-radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG): Updated...

por Lazow, Margot A, DeWire, Mariko, Campagne, Olivia, Leach, James L, Fuller, Christine, Kumar, Shiva Senthil, Stanek, Joseph, de Blank, Peter, Hummel, Trent R, Pillay-Smiley, Natasha, Salloum, Ralph, Stevenson, Charles B, Baxter, Patricia, Gass, David, Goldman, Stewart, Leary, Sarah E S, Carle, Adam, Lane, Adam, Drissi, Rachid, Stewart, Clinton, Fouladi, Maryam
Publicado 2022