Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase

por Coey, Christopher T, Drohat, Alexander C
Publicado 2018

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA

por Drohat, Alexander C., Pozharski, Edwin, Maiti, Atanu
Publicado 2012

Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA

por Morgan, Michael T., Maiti, Atanu, Fitzgerald, Megan E., Drohat, Alexander C.
Publicado 2011

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging

por Buechner, Claudia N., Maiti, Atanu, Drohat, Alexander C., Tessmer, Ingrid
Publicado 2015

Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg(2+) cofactor

por Manvilla, Brittney A., Pozharski, Edwin, Toth, Eric A., Drohat, Alexander C.
Publicado 2013

Rapid excision of oxidized adenine by human thymine DNA glycosylase

por Servius, Hardler W., Pidugu, Lakshmi S., Sherman, Matthew E., Drohat, Alexander C.
Publicado 2022

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

por Malik, Shuja S., Coey, Christopher T., Varney, Kristen M., Pozharski, Edwin, Drohat, Alexander C.
Publicado 2015

Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues

por Coey, Christopher T., Malik, Shuja S., Pidugu, Lakshmi S., Varney, Kristen M., Pozharski, Edwin, Drohat, Alexander C.
Publicado 2016

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase

por Guan, Xin, Madabushi, Amrita, Chang, Dau-Yin, Fitzgerald, Megan E., Shi, Gouli, Drohat, Alexander C., Lu, A-Lien
Publicado 2007

Functional Assessment of Population and Tumor-Associated APE1 Protein Variants

por Illuzzi, Jennifer L., Harris, Nicole A., Manvilla, Brittney A., Kim, Daemyung, Li, Mengxia, Drohat, Alexander C., Wilson, David M.
Publicado 2013

Characterizing inhibitors of human AP endonuclease 1

por Pidugu, Lakshmi S., Servius, Hardler W., Sevdalis, Spiridon E., Cook, Mary E., Varney, Kristen M., Pozharski, Edwin, Drohat, Alexander C.
Publicado 2023