Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

por Calandrini, Camilla, Drost, Jarno
Publicado 2022

In vitro Modeling of Embryonal Tumors

por Custers, Lars, Paassen, Irene, Drost, Jarno
Publicado 2021

Xenograft and organoid model systems in cancer research

por Bleijs, Margit, van de Wetering, Marc, Clevers, Hans, Drost, Jarno
Publicado 2019

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

por Loayza-Puch, Fabricio, Drost, Jarno, Rooijers, Koos, Lopes, Rui, Elkon, Ran, Agami, Reuven
Publicado 2013

Organoid culture systems for prostate epithelial tissue and prostate cancer tissue

por Drost, Jarno, Karthaus, Wouter R., Gao, Dong, Driehuis, Else, Sawyers, Charles L., Chen, Yu, Clevers, Hans
Publicado 2016

E2F mediates enhanced alternative polyadenylation in proliferation

por Elkon, Ran, Drost, Jarno, van Haaften, Gijs, Jenal, Mathias, Schrier, Mariette, Oude Vrielink, Joachim AF, Agami, Reuven
Publicado 2012

Somatic, Genetic and Epigenetic Changes in Nephrogenic Rests and Their Role in the Transformation to Wilms Tumors, a Systematic Review

por Bánki, Tessa, Drost, Jarno, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M. C., de Krijger, Ronald R.
Publicado 2023

Oncogenic signaling is coupled to colorectal cancer cell differentiation state

por Sell, Thomas, Klotz, Christian, Fischer, Matthias M., Astaburuaga-García, Rosario, Krug, Susanne, Drost, Jarno, Clevers, Hans, Sers, Christine, Morkel, Markus, Blüthgen, Nils
Publicado 2023

CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia

por Schneider, Pauline, Wander, Priscilla, Arentsen-Peters, Susan T. C. J. M., Vrenken, Kirsten S., Rockx-Brouwer, Dedeke, Adriaanse, Fabienne R. S., Hoeve, Veerle, Paassen, Irene, Drost, Jarno, Pieters, Rob, Stam, Ronald W.
Publicado 2023

SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors

por Liu, Ning Qing, Paassen, Irene, Custers, Lars, Zeller, Peter, Teunissen, Hans, Ayyildiz, Dilara, He, Jiayou, Buhl, Juliane Laura, Hoving, Eelco Wieger, van Oudenaarden, Alexander, de Wit, Elzo, Drost, Jarno
Publicado 2023

Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

por Kester, Lennart, de Barbanson, Buys, Lyubimova, Anna, Chen, Li-Ting, van der Schrier, Valérie, Alemany, Anna, Mooijman, Dylan, Peterson-Maduro, Josi, Drost, Jarno, de Ridder, Jeroen, van Oudenaarden, Alexander
Publicado 2022

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS(G12D) glycolytic colorectal tumors

por Ludikhuize, Marlies C., Gevers, Sira, Nguyen, Nguyen T. B., Meerlo, Maaike, Roudbari, S. Khadijeh Shafiei, Gulersonmez, M. Can, Stigter, Edwin C. A., Drost, Jarno, Clevers, Hans, Burgering, Boudewijn M. T., Rodríguez Colman, Maria J.
Publicado 2022

ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma

por Heim, Catrin, Moser, Laura M., Kreyenberg, Herman, Bonig, Halvard B., Tonn, Torsten, Wels, Winfried S., Gradhand, Elise, Ullrich, Evelyn, Meister, Michael T., Koerkamp, Marian Groot, Holstege, Frank C. P., Drost, Jarno, Klusmann, Jan-Henning, Bader, Peter, Merker, Michael, Rettinger, Eva
Publicado 2023

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

por Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, van Gerwen, Bastiaan, van der Ven, Marieke, van de Wetering, Marc, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Publicado 2016

Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures

por Caipa Garcia, Angela L., Kucab, Jill E., Al-Serori, Halh, Beck, Rebekah S. S., Fischer, Franziska, Hufnagel, Matthias, Hartwig, Andrea, Floeder, Andrew, Balbo, Silvia, Francies, Hayley, Garnett, Mathew, Huch, Meritxell, Drost, Jarno, Zilbauer, Matthias, Arlt, Volker M., Phillips, David H.
Publicado 2022

Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

por Groenendijk, Alissa, Spreafico, Filippo, de Krijger, Ronald R., Drost, Jarno, Brok, Jesper, Perotti, Daniela, van Tinteren, Harm, Venkatramani, Rajkumar, Godziński, Jan, Rübe, Christian, Geller, James I., Graf, Norbert, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M. C.
Publicado 2021

LGR6 marks nephron progenitor cells

por van Ineveld, Ravian L., Margaritis, Thanasis, Kooiman, Berend A.P., Groenveld, Femke, Ariese, Hendrikus C.R., Lijnzaad, Philip, Johnson, Hannah R., Korving, Jeroen, Wehrens, Ellen J., Holstege, Frank, van Rheenen, Jacco, Drost, Jarno, Rios, Anne C., Bos, Frank L.
Publicado 2021

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

por DeMartino, Jeff, Meister, Michael T., Visser, Lindy L., Brok, Mariël, Groot Koerkamp, Marian J. A., Wezenaar, Amber K. L., Hiemcke-Jiwa, Laura S., de Souza, Terezinha, Merks, Johannes H. M., Rios, Anne C., Holstege, Frank C. P., Margaritis, Thanasis, Drost, Jarno
Publicado 2023

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

por Fessler, Evelyn, Drost, Jarno, van Hooff, Sander R, Linnekamp, Janneke F, Wang, Xin, Jansen, Marnix, De Sousa E Melo, Felipe, Prasetyanti, Pramudita R, IJspeert, Joep EG, Franitza, Marek, Nürnberg, Peter, van Noesel, Carel JM, Dekker, Evelien, Vermeulen, Louis, Clevers, Hans, Medema, Jan Paul
Publicado 2016

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

por Paassen, Irene, Williams, Justin, Ríos Arceo, Carla, Ringnalda, Femke, Mercer, Kimberly Shea, Buhl, Juliane L., Moreno, Natalia, Federico, Aniello, Franke, Niels E., Kranendonk, Mariette, Upadhyaya, Santhosh A., Kerl, Kornelius, van de Wetering, Marc, Clevers, Hans, Kool, Marcel, Hoving, Eelco W., Roussel, Martine F., Drost, Jarno
Publicado 2023