Bipartite interface of the measles virus phosphoprotein X domain with the large polymerase protein regulates viral polymerase dynamics

por Du Pont, Venice, Jiang, Yi, Plemper, Richard K.
Publicado 2019

In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance

por Checkmahomed, Liva, Carbonneau, Julie, Du Pont, Venice, Riola, Nicholas C., Perry, Jason K., Li, Jiani, Paré, Bastien, Simpson, Shawn M., Smith, Martin A., Porter, Danielle P., Boivin, Guy
Publicado 2022

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

por Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.
Publicado 2022

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

por Pitts, Jared, Li, Jiani, Perry, Jason K., Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P., Mo, Hongmei, Maiorova, Evguenia, Bilello, John P.
Publicado 2022

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

por Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.
Publicado 2021

539. Efficacy in Multiple SARS-CoV-2 Animal Models Supports Phase 3 Dose Selection for Obeldesivir

por Pitts, Jared, Babusis, Darius, Humeniuk, Rita, Martinez, David, Cox, Robert M, Schäfer, Alexandra, Riola, Nicholas C, Feng, Joy, Du Pont, Venice, Anoshchenko, Olena, Vermillion, Meghan, Abdelghany, Mazin, Hyland, Robert H, Girish, Sandhya, Sheahan, Timothy P, Plemper, Richard K, Baric, Ralph S, Cihlar, Tomas, Llewellyn, Joe, Winter, Helen, Bannister, Roy, Subramanian, Raju, Mackman, Richard L, Bilello, John P
Publicado 2023

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

por Schäfer, Alexandra, Martinez, David R., Won, John J., Moreira, Fernando R., Brown, Ariane J., Gully, Kendra L., Kalla, Rao, Chun, Kwon, Du Pont, Venice, Babusis, Darius, Tang, Jennifer, Murakami, Eisuke, Subramanian, Raju, Barrett, Kimberly T, Bleier, Blake J., Bannister, Roy, Feng, Joy Y., Bilello, John P., Cihlar, Tomas, Mackman, Richard L., Montgomery, Stephanie A., Baric, Ralph S., Sheahan, Timothy P.
Publicado 2021

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

por Schäfer, Alexandra, Martinez, David R., Won, John J., Meganck, Rita M., Moreira, Fernando R., Brown, Ariane J., Gully, Kendra L., Zweigart, Mark R., Conrad, William S., May, Samantha R., Dong, Stephanie, Kalla, Rao, Chun, Kwon, Du Pont, Venice, Babusis, Darius, Tang, Jennifer, Murakami, Eisuke, Subramanian, Raju, Barrett, Kimberly T., Bleier, Blake J., Bannister, Roy, Feng, Joy Y., Bilello, John P., Cihlar, Tomas, Mackman, Richard L., Montgomery, Stephanie A., Baric, Ralph S., Sheahan, Timothy P.
Publicado 2022

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

por Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.
Publicado 2020