Endogenous retroviruses and TDP-43 proteinopathy form a sustaining feedback driving intercellular spread of Drosophila neurodegeneration

por Chang, Yung-Heng, Dubnau, Josh
Publicado 2023

Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders

por Li, Wanhe, Jin, Ying, Prazak, Lisa, Hammell, Molly, Dubnau, Josh
Publicado 2012

Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells...

por Chang, Yung-Heng, Keegan, Richard M., Prazak, Lisa, Dubnau, Josh
Publicado 2019

A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia

por Azpurua, Jorge, El-Karim, Enas Gad, Tranquille, Marvel, Dubnau, Josh
Publicado 2021

TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1

por Krupp, Sarah, Hubbard, Isabel, Tam, Oliver, Hammell, Gale M., Dubnau, Josh
Publicado 2023

Nuclear Transcriptomes of the Seven Neuronal Cell Types That Constitute the Drosophila Mushroom Bodies

por Shih, Meng-Fu Maxwell, Davis, Fred Pejman, Henry, Gilbert Lee, Dubnau, Josh
Publicado 2018

Intercellular viral spread and intracellular transposition of Drosophila gypsy

por Keegan, Richard M., Talbot, Lillian R., Chang, Yung-Heng, Metzger, Michael J., Dubnau, Josh
Publicado 2021

Identification of Synaptic Targets of Drosophila Pumilio

por Chen, Gengxin, Li, Wanhe, Zhang, Qing-Shuo, Regulski, Michael, Sinha, Nishi, Barditch, Jody, Tully, Tim, Krainer, Adrian R., Zhang, Michael Q., Dubnau, Josh
Publicado 2008

Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

por Krug, Lisa, Chatterjee, Nabanita, Borges-Monroy, Rebeca, Hearn, Stephen, Liao, Wen-Wei, Morrill, Kathleen, Prazak, Lisa, Rozhkov, Nikolay, Theodorou, Delphine, Hammell, Molly, Dubnau, Josh
Publicado 2017

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

por Tam, Oliver H., Rozhkov, Nikolay V., Shaw, Regina, Kim, Duyang, Hubbard, Isabel, Fennessey, Samantha, Propp, Nadia, Fagegaltier, Delphine, Harris, Brent T., Ostrow, Lyle W., Phatnani, Hemali, Ravits, John, Dubnau, Josh, Hammell, Molly Gale
Publicado 2019

Mobile genetic elements and genome evolution 2014

por Singh, Parmit Kumar, Bourque, Guillaume, Craig, Nancy L, Dubnau, Josh T, Feschotte, Cédric, Flasch, Diane A, Gunderson, Kevin L, Malik, Harmit Singh, Moran, John V, Peters, Joseph E, Slotkin, R Keith, Levin, Henry L
Publicado 2014