Rehabilitating drug-induced long-QT promoters: In-silico design of hERG-neutral cisapride analogues with retained pharmacological activity

por Durdagi, Serdar, Randall, Trevor, Duff, Henry J, Chamberlin, Adam, Noskov, Sergei Y
Publicado 2014

­Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy

por AlKhaleefa, Ayaa, Snider, Frances L., Duff, Henry J., McGhee, James D.
Publicado 2020

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes

por Shafa, Mehdi, Krawetz, Roman, Zhang, Yuan, Rattner, Jerome B, Godollei, Anna, Duff, Henry J, Rancourt, Derrick E
Publicado 2011

Phenotypic Analysis of Arrhythmogenic Cardiomyopathy in the Hutterite Population: Role of Electrocardiogram in Identifying High‐Risk Desmocollin‐2 Carriers

por Wong, Jorge A., Duff, Henry J., Yuen, Tiffany, Kolman, Louis, Exner, Derek V., Weeks, Sarah G., Gerull, Brenda
Publicado 2014

Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade

por Kudaibergenova, Meruyert, Guo, Jiqing, Khan, Hanif M., Zahid, Farhan, Lees-Miller, James, Noskov, Sergei Yu., Duff, Henry J.
Publicado 2020

Role of the pH in state-dependent blockade of hERG currents

por Wang, Yibo, Guo, Jiqing, Perissinotti, Laura L., Lees-Miller, James, Teng, Guoqi, Durdagi, Serdar, Duff, Henry J., Noskov, Sergei Yu.
Publicado 2016

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators

por Guo, Jiqing, Durdagi, Serdar, Changalov, Mohamed, Perissinotti, Laura L., Hargreaves, Jason M., Back, Thomas G., Noskov, Sergei Y., Duff, Henry J.
Publicado 2014

Lipid regulation of hERG1 channel function

por Miranda, Williams E., Guo, Jiqing, Mesa-Galloso, Haydee, Corradi, Valentina, Lees-Miller, James P., Tieleman, D. Peter, Duff, Henry J., Noskov, Sergei Yu.
Publicado 2021

Ketones Prevent Oxidative Impairment of Hippocampal Synaptic Integrity through K(ATP) Channels

por Kim, Do Young, Abdelwahab, Mohammed G., Lee, Soo Han, O’Neill, Derek, Thompson, Roger J., Duff, Henry J., Sullivan, Patrick G., Rho, Jong M.
Publicado 2015

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study

por Perissinotti, Laura L., De Biase, Pablo M., Guo, Jiqing, Yang, Pei-Chi, Lee, Miranda C., Clancy, Colleen E., Duff, Henry J., Noskov, Sergei Y.
Publicado 2018

A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources

por Kernik, Divya C., Morotti, Stefano, Wu, HaoDi, Garg, Priyanka, Duff, Henry J., Kurokawa, Junko, Jalife, José, Wu, Joseph C., Grandi, Eleonora, Clancy, Colleen E.
Publicado 2019

The voltage-sensing domain of a hERG1 mutant is a cation-selective channel

por Kudaibergenova, Meruyert, Guo, Jiqing, Khan, Hanif M., Lees-Miller, James, Mousaei, Mahdi, Miranda, Williams, Ngo, Van A., Noskov, Sergei Yu, Tieleman, D. Peter, Duff, Henry J.
Publicado 2022

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2

por Abdelfatah, Nelly, Chen, Ruping, Duff, Henry J., Seifer, Colette M., Buffo, Ilan, Huculak, Cathleen, Clarke, Stephanie, Clegg, Robin, Jassal, Davinder S., Gordon, Paul M.K., Ober, Carole, Frosk, Patrick, Gerull, Brenda
Publicado 2019

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study

por Ezekowitz, Justin A, Becher, Harald, Belenkie, Israel, Clark, Alexander M, Duff, Henry J, Friedrich, Matthias G, Haykowsky, Mark J, Howlett, Jonathan G, Kassiri, Zamaneh, Kaul, Padma, Kim, Daniel H, Knudtson, Merril L, Light, Peter E, Lopaschuk, Gary D, McAlister, Finlay A, Noga, Michelle L, Oudit, Gavin Y, Paterson, D Ian, Quan, Hude, Schulz, Richard, Thompson, Richard B, Weeks, Sarah G, Anderson, Todd J, Dyck, Jason RB
Publicado 2014