The SCLtTAxBCR-ABL transgenic mouse model closely reflects the differential effects of dasatinib on normal and malignant hematopoiesis in chronic phase-CML patients

por Schubert, Claudia, Chatain, Nicolas, Braunschweig, Till, Schemionek, Mirle, Feldberg, Kristina, Hoffmann, Melanie, Dufva, Olli, Mustjoki, Satu, Brümmendorf, Tim H., Koschmieder, Steffen
Publicado 2017

Data-driven characterization of molecular phenotypes across heterogeneous sample collections

por Mehtonen, Juha, Pölönen, Petri, Häyrynen, Sergei, Dufva, Olli, Lin, Jake, Liuksiala, Thomas, Granberg, Kirsi, Lohi, Olli, Hautamäki, Ville, Nykter, Matti, Heinäniemi, Merja
Publicado 2019

Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia

por Hohtari, Helena, Kankainen, Matti, Adnan-Awad, Shady, Yadav, Bhagwan, Potdar, Swapnil, Ianevski, Aleksandr, Dufva, Olli, Heckman, Caroline, Sexl, Veronika, Kytölä, Soili, Mustjoki, Satu, Porkka, Kimmo
Publicado 2022

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

por Kuusanmäki, Heikki, Dufva, Olli, Parri, Elina, van Adrichem, Arjan J., Rajala, Hanna, Majumder, Muntasir M., Yadav, Bhagwan, Parsons, Alun, Chan, Wing C., Wennerberg, Krister, Mustjoki, Satu, Heckman, Caroline A.
Publicado 2017

P1228: GENOME-WIDE CRISPR-CAS9 SCREENING IDENTIFIES THERAPEUTIC TARGETS FOR MATURE T-CELL MALIGNANCIES

por Timonen, Sanna, Rebecca Gasparini, Vanessa, Piekkari, Ella, Dufva, Olli, Awad, Shady, Akimov, Yevhen, von Jan, Jana, Braun, Till, Ianevski, Aleksandr, Kankainen, Matti, Klievink, Jay, Herling, Marco, Aittokallio, Tero, Mustjoki, Satu
Publicado 2023

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

por Kuusanmäki, Heikki, Leppä, Aino-Maija, Pölönen, Petri, Kontro, Mika, Dufva, Olli, Deb, Debashish, Yadav, Bhagwan, Brück, Oscar, Kumar, Ashwini, Everaus, Hele, Gjertsen, Bjørn T., Heinäniemi, Merja, Porkka, Kimmo, Mustjoki, Satu, Heckman, Caroline A.
Publicado 2020

P409: BCL-2/BCL-XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53-MUTATED ACUTE MYELOID LEUKEMIA

por Vänttinen, Ida, Kytölä, Sari, Dufva, Olli, Hellesøy, Monica, Gullaksen, Stein-Erik, Ruokoranta, Tanja, Brück, Oscar, Siitonen, Sanna, Ettala, Pia, Pyörälä, Marja, Rimpilainen, Johanna, Siitonen, Timo, Tore Gjertsen, Bjorn, Heckman, Caroline, Kuusanmäki, Heikki, Kontro, Mika
Publicado 2023

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses

por Adnan Awad, Shady, Dufva, Olli, Ianevski, Aleksandr, Ghimire, Bishwa, Koski, Jan, Maliniemi, Pilvi, Thomson, Daniel, Schreiber, Andreas, Heckman, Caroline A., Koskenvesa, Perttu, Korhonen, Matti, Porkka, Kimmo, Branford, Susan, Aittokallio, Tero, Kankainen, Matti, Mustjoki, Satu
Publicado 2020

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

por Kämpjärvi, Kati, Järvinen, Tiina M., Heikkinen, Tuomas, Ruppert, Amy S., Senter, Leigha, Hoag, Kevin W., Dufva, Olli, Kontro, Mika, Rassenti, Laura, Hertlein, Erin, Kipps, Thomas J., Porkka, Kimmo, Byrd, John C., de la Chapelle, Albert, Vahteristo, Pia
Publicado 2014

Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma

por Huuhtanen, Jani, Kasanen, Henna, Peltola, Katriina, Lönnberg, Tapio, Glumoff, Virpi, Brück, Oscar, Dufva, Olli, Peltonen, Karita, Vikkula, Johanna, Jokinen, Emmi, Ilander, Mette, Lee, Moon Hee, Mäkelä, Siru, Nyakas, Marta, Li, Bin, Hernberg, Micaela, Bono, Petri, Lähdesmäki, Harri, Kreutzman, Anna, Mustjoki, Satu
Publicado 2023

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia

por Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika
Publicado 2022

IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia

por Huuhtanen, Jani, Ilander, Mette, Yadav, Bhagwan, Dufva, Olli M.J., Lähteenmäki, Hanna, Kasanen, Tiina, Klievink, Jay, Olsson-Strömberg, Ulla, Stentoft, Jesper, Richter, Johan, Koskenvesa, Perttu, Höglund, Martin, Söderlund, Stina, Dreimane, Arta, Porkka, Kimmo, Gedde-Dahl, Tobias, Gjertsen, Björn T., Stenke, Leif, Myhr-Eriksson, Kristina, Markevärn, Berit, Lübking, Anna, Dimitrijevic, Andreja, Udby, Lene, Bjerrum, Ole Weis, Hjorth-Hansen, Henrik, Mustjoki, Satu
Publicado 2022

Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

por Malani, Disha, Kumar, Ashwini, Brück, Oscar, Kontro, Mika, Yadav, Bhagwan, Hellesøy, Monica, Kuusanmäki, Heikki, Dufva, Olli, Kankainen, Matti, Eldfors, Samuli, Potdar, Swapnil, Saarela, Jani, Turunen, Laura, Parsons, Alun, Västrik, Imre, Kivinen, Katja, Saarela, Janna, Räty, Riikka, Lehto, Minna, Wolf, Maija, Gjertsen, Bjorn Tore, Mustjoki, Satu, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline A., Kallioniemi, Olli, Porkka, Kimmo
Publicado 2022

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

por Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E., Ojala, Teija, Lee, Dean A., Loughran, Thomas P., Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Aittokallio, Tero, Chan, Wing C., Ohshima, Koichi, Ishida, Fumihiro, Mustjoki, Satu
Publicado 2018

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

por Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu
Publicado 2023