Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK

por Dai, Sheng, Dulcey, Andrés E., Hu, Xin, Wassif, Christopher A., Porter, Forbes D., Austin, Christopher P., Ory, Daniel S., Marugan, Juan, Zheng, Wei
Publicado 2017

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

por He, Shanshan, Xiao, Jingbo, Dulcey, Andrés E., Lin, Billy, Rolt, Adam, Hu, Zongyi, Hu, Xin, Wang, Amy Q., Xu, Xin, Southall, Noel, Ferrer, Marc, Zheng, Wei, Liang, T. Jake, Marugan, Juan J.
Publicado 2015

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus

por Mukhopadhyay, Rupkatha, Roy, Sujayita, Venkatadri, Rajkumar, Su, Yu-Pin, Ye, Wenjuan, Barnaeva, Elena, Mathews Griner, Lesley, Southall, Noel, Hu, Xin, Wang, Amy Q., Xu, Xin, Dulcey, Andrés E., Marugan, Juan J., Ferrer, Marc, Arav-Boger, Ravit
Publicado 2016

Discovery, Optimization, and Characterization of Novel D(2) Dopamine Receptor Selective Antagonists

por Xiao, Jingbo, Free, R. Benjamin, Barnaeva, Elena, Conroy, Jennie L., Doyle, Trevor, Miller, Brittney, Bryant-Genevier, Marthe, Taylor, Mercedes K., Hu, Xin, Dulcey, Andrés E., Southall, Noel, Ferrer, Marc, Titus, Steve, Zheng, Wei, Sibley, David R., Marugan, Juan J.
Publicado 2014

c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease

por León, Rilda, Gutiérrez, Daniela A., Pinto, Claudio, Morales, Cristian, de la Fuente, Catalina, Riquelme, Cristóbal, Cortés, Bastián I., González-Martin, Adrián, Chamorro, David, Espinosa, Nelson, Fuentealba, Pablo, Cancino, Gonzalo I., Zanlungo, Silvana, Dulcey, Andrés E., Marugan, Juan J., Álvarez Rojas, Alejandra
Publicado 2023

Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells

por Singh, Anju, Dashnyam, Myagmarjav, Chim, Bryan, Escobar, Thelma M., Dulcey, Andrés E., Hu, Xin, Wilson, Kelli M., Koganti, Prasanthi P., Spinner, Camille A., Xu, Xin, Jadhav, Ajit, Southall, Noel, Marugan, Juan, Selvaraj, Vimal, Lazarevic, Vanja, Muljo, Stefan A., Ferrer, Marc
Publicado 2020

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration

por Martinez, Alexis, Lamaizon, Cristian M., Valls, Cristian, Llambi, Fabien, Leal, Nancy, Fitzgerald, Patrick, Guy, Cliff, Kamiński, Marcin M., Inestrosa, Nibaldo C., van Zundert, Brigitte, Cancino, Gonzalo I., Dulcey, Andrés E., Zanlungo, Silvana, Marugan, Juan J., Hetz, Claudio, Green, Douglas R., Alvarez, Alejandra R.
Publicado 2023

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease

por Marín, Tamara, Dulcey, Andrés E., Campos, Fabián, de la Fuente, Catalina, Acuña, Mariana, Castro, Juan, Pinto, Claudio, Yañez, María José, Cortez, Cristian, McGrath, David W., Sáez, Pablo J., Gorshkov, Kirill, Zheng, Wei, Southall, Noel, Carmo-Fonseca, Maria, Marugán, Juan, Alvarez, Alejandra R., Zanlungo, Silvana
Publicado 2022

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

por Ma, Christopher D., Imamura, Michio, Talley, Daniel C., Rolt, Adam, Xu, Xin, Wang, Amy Q., Le, Derek, Uchida, Takuro, Osawa, Mitsutaka, Teraoka, Yuji, Li, Kelin, Hu, Xin, Park, Seung Bum, Chalasani, Nishanth, Irvin, Parker H., Dulcey, Andres E., Southall, Noel, Marugan, Juan J., Hu, Zongyi, Chayama, Kazuaki, Frankowski, Kevin J., Liang, T. Jake
Publicado 2020

In vivo characterization of the physicochemical properties of TLR agonist delivery that enhance vaccine immunogenicity

por Lynn, Geoffrey M., Laga, Richard, Darrah, Patricia A., Ishizuka, Andrew S., Balaci, Alexandra J., Dulcey, Andrés E., Pechar, Michal, Pola, Robert, Gerner, Michael Y., Yamamoto, Ayako, Buechler, Connor R., Quinn, Kylie M., Smelkinson, Margery G., Vanek, Ondrej, Cawood, Ryan, Hills, Thomas, Vasalatiy, Olga, Kastenmuller, Kathrin, Francica, Joseph R., Stutts, Lalisa, Tom, Janine K., Ryu, Keun Ah, Esser-Kahn, Aaron P., Etrych, Tomas, Fisher, Kerry D., Seymour, Leonard W., Seder, Robert A.
Publicado 2015