YcaO domains utilize ATP to activate amide backbones during peptide cyclodehydrations

por Dunbar, Kyle L, Melby, Joel O, Mitchell, Douglas A
Publicado 2012

Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy

por Dunbar, Kyle L., Dell, Maria, Gude, Finn, Hertweck, Christian
Publicado 2020

A Prevalent Peptide-Binding Domain Guides Ribosomal Natural Product Biosynthesis

por Burkhart, Brandon J., Hudson, Graham A., Dunbar, Kyle L., Mitchell, Douglas A.
Publicado 2015

Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones

por Dunbar, Kyle L., Dell, Maria, Molloy, Evelyn M., Kloss, Florian, Hertweck, Christian
Publicado 2019

An Unexpected Split‐Merge Pathway in the Assembly of the Symmetric Nonribosomal Peptide Antibiotic Closthioamide

por Dunbar, Kyle L., Dell, Maria, Molloy, Evelyn M., Büttner, Hannah, Kumpfmüller, Jana, Hertweck, Christian
Publicado 2020

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

por Dunbar, Kyle L., Chekan, Jonathan R., Cox, Courtney L., Burkhart, Brandon J., Nair, Satish K., Mitchell, Douglas A.
Publicado 2014

A Specialized Polythioamide‐Binding Protein Confers Antibiotic Self‐Resistance in Anaerobic Bacteria

por Gude, Finn, Molloy, Evelyn M., Horch, Therese, Dell, Maria, Dunbar, Kyle L., Krabbe, Jana, Groll, Michael, Hertweck, Christian
Publicado 2022

Alternative Benzoxazole Assembly Discovered in Anaerobic Bacteria Provides Access to Privileged Heterocyclic Scaffold

por Horch, Therese, Molloy, Evelyn M., Bredy, Florian, Haensch, Veit G., Scherlach, Kirstin, Dunbar, Kyle L., Franke, Jonathan, Hertweck, Christian
Publicado 2022

Enzyme‐Primed Native Chemical Ligation Produces Autoinducing Cyclopeptides in Clostridia

por Molloy, Evelyn M., Dell, Maria, Hänsch, Veit G., Dunbar, Kyle L., Feldmann, Romy, Oberheide, Ansgar, Seyfarth, Lydia, Kumpfmüller, Jana, Horch, Therese, Arndt, Hans‐Dieter, Hertweck, Christian
Publicado 2021

Resistance gene–guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases

por Dunbar, Kyle L., Perlatti, Bruno, Liu, Nicholas, Cornelius, Amber, Mummau, Daniel, Chiang, Yi-Ming, Hon, Lawrence, Nimavat, Monika, Pallas, Jason, Kordes, Sina, Ng, Ho Leung, Harvey, Colin J. B.
Publicado 2023