Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies

por Alford, Joshua S., Lampe, John W., Brach, Dorothy, Chesworth, Richard, Cosmopoulos, Kat, Duncan, Kenneth W., Eckley, Sean T., Kutok, Jeffrey L., Raimondi, Alejandra, Riera, Thomas V., Shook, Brian, Tang, Cuyue, Totman, Jennifer, Farrow, Neil A.
Publicado 2022

Identification of a peptide inhibitor for the histone methyltransferase WHSC1

por Morrison, Michael J., Boriack-Sjodin, P. Ann, Swinger, Kerren K., Wigle, Tim J., Sadalge, Dipti, Kuntz, Kevin W., Scott, Margaret Porter, Janzen, William P., Chesworth, Richard, Duncan, Kenneth W., Harvey, Darren M., Lampe, John W., Mitchell, Lorna H., Copeland, Robert A.
Publicado 2018

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

por Gerhart, Sarah V., Kellner, Wendy A., Thompson, Christine, Pappalardi, Melissa B., Zhang, Xi-Ping, Montes de Oca, Rocio, Penebre, Elayne, Duncan, Kenneth, Boriack-Sjodin, Ann, Le, BaoChau, Majer, Christina, McCabe, Michael T., Carpenter, Chris, Johnson, Neil, Kruger, Ryan G., Barbash, Olena
Publicado 2018

Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies

por Lampe, John W., Alford, Joshua S., Boriak-Sjodin, P. Ann, Brach, Dorothy, Cosmopoulos, Kat, Duncan, Kenneth W., Eckley, Sean T., Foley, Megan A., Harvey, Darren M., Motwani, Vinny, Munchhof, Michael J., Raimondi, Alejandra, Riera, Thomas V., Tang, Cuyue, Thomenius, Michael J., Totman, Jennifer, Farrow, Neil A.
Publicado 2021

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

por Drew, Allison E., Moradei, Oscar, Jacques, Suzanne L., Rioux, Nathalie, Boriack-Sjodin, Ann P., Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L., Ott, Heidi M., Kruger, Ryan G., McCabe, Michael T., Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J., Mitchell, Lorna H., Duncan, Kenneth W., Moyer, Mikel P., Copeland, Robert A., Smith, Jesse, Chesworth, Richard, Ribich, Scott A.
Publicado 2017