HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta

por Dickson, Alison, Yutuc, Eylan, Thornton, Catherine A., Dunford, James E., Oppermann, Udo, Wang, Yuqin, Griffiths, William J.
Publicado 2023

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

por Pilka, Ewa S., Niesen, Frank H., Lee, Wen Hwa, El-Hawari, Yasser, Dunford, James E., Kochan, Grazyna, Wsol, Vladimir, Martin, Hans-Joerg, Maser, Edmund, Oppermann, Udo
Publicado 2009

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

por Artz, Jennifer D., Wernimont, Amy K., Dunford, James E., Schapira, Matthieu, Dong, Aiping, Zhao, Yong, Lew, Jocelyne, Russell, R. Graham G., Ebetino, F. Hal, Oppermann, Udo, Hui, Raymond
Publicado 2011

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2

por Davis-Gilbert, Zachary W., Krämer, Andreas, Dunford, James E., Howell, Stefanie, Senbabaoglu, Filiz, Wells, Carrow I., Bashore, Frances M., Havener, Tammy M., Smith, Jeffery L., Hossain, Mohammad A., Oppermann, Udo, Drewry, David H., Axtman, Alison D.
Publicado 2023

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using en...

por Tsoumpra, Maria K., Muniz, Joao R., Barnett, Bobby L., Kwaasi, Aaron A., Pilka, Ewa S., Kavanagh, Kathryn L., Evdokimov, Artem, Walter, Richard L., Von Delft, Frank, Ebetino, Frank H., Oppermann, Udo, Russell, R. Graham G., Dunford, James E.
Publicado 2015

BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming

por Sevinç, Kenan, Sevinç, Gülben Gürhan, Cavga, Ayşe Derya, Philpott, Martin, Kelekçi, Simge, Can, Hazal, Cribbs, Adam P., Yıldız, Abdullah Burak, Yılmaz, Alperen, Ayar, Enes Sefa, Arabacı, Dilşad H., Dunford, James E., Ata, Deniz, Sigua, Logan H., Qi, Jun, Oppermann, Udo, Onder, Tamer T.
Publicado 2022

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)

por Lawson, Michelle A, Ebetino, Frank H, Mazur, Adam, Chantry, Andrew D, Paton‐Hough, Julia, Evans, Holly R, Lath, Darren, Tsoumpra, Maria K, Lundy, Mark W, Dobson, Roy LM, Quijano, Michael, Kwaasi, Aaron A, Dunford, James E, Duan, Xuchen, Triffitt, James T, Jeans, Gwyn, Russell, R Graham G
Publicado 2017

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

por Yang, Shyh-Ming, Martinez, Natalia J., Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q., Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S., Roth, Jacob, Lal-Nag, Madhu, Dunford, James E., Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J.
Publicado 2018

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

por Vazquez‐Rodriguez, Saleta, Wright, Miranda, Rogers, Catherine M., Cribbs, Adam P., Velupillai, Srikannathasan, Philpott, Martin, Lee, Henry, Dunford, James E., Huber, Kilian V. M., Robers, Matthew B., Vasta, James D., Thezenas, Marie‐Laetitia, Bonham, Sarah, Kessler, Benedikt, Bennett, James, Fedorov, Oleg, Raynaud, Florence, Donovan, Adam, Blagg, Julian, Bavetsias, Vassilios, Oppermann, Udo, Bountra, Chas, Kawamura, Akane, Brennan, Paul E.
Publicado 2018

GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome

por Foley, A. Reghan, Zou, Yaqun, Dunford, James E., Rooney, Jachinta, Chandra, Goutam, Xiong, Hui, Straub, Volker, Voit, Thomas, Romero, Norma, Donkervoort, Sandra, Hu, Ying, Markello, Thomas, Horn, Adam, Qebibo, Leila, Dastgir, Jahannaz, Meilleur, Katherine G., Finkel, Richard S., Fan, Yanbin, Mamchaoui, Kamel, Duguez, Stephanie, Nelson, Isabelle, Laporte, Jocelyn, Santi, Mariarita, Malfatti, Edoardo, Maisonobe, Thierry, Touraine, Philippe, Hirano, Michio, Hughes, Imelda, Bushby, Kate, Oppermann, Udo, Böhm, Johann, Jaiswal, Jyoti K., Stojkovic, Tanya, Bönnemann, Carsten G.
Publicado 2020

Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases

por Pagnamenta, Alistair T., Camps, Carme, Giacopuzzi, Edoardo, Taylor, John M., Hashim, Mona, Calpena, Eduardo, Kaisaki, Pamela J., Hashimoto, Akiko, Yu, Jing, Sanders, Edward, Schwessinger, Ron, Hughes, Jim R., Lunter, Gerton, Dreau, Helene, Ferla, Matteo, Lange, Lukas, Kesim, Yesim, Ragoussis, Vassilis, Vavoulis, Dimitrios V., Allroggen, Holger, Ansorge, Olaf, Babbs, Christian, Banka, Siddharth, Baños-Piñero, Benito, Beeson, David, Ben-Ami, Tal, Bennett, David L., Bento, Celeste, Blair, Edward, Brasch-Andersen, Charlotte, Bull, Katherine R., Cario, Holger, Cilliers, Deirdre, Conti, Valerio, Davies, E. Graham, Dhalla, Fatima, Dacal, Beatriz Diez, Dong, Yin, Dunford, James E., Guerrini, Renzo, Harris, Adrian L., Hartley, Jane, Hollander, Georg, Javaid, Kassim, Kane, Maureen, Kelly, Deirdre, Kelly, Dominic, Knight, Samantha J. L., Kreins, Alexandra Y., Kvikstad, Erika M., Langman, Craig B., Lester, Tracy, Lines, Kate E., Lord, Simon R., Lu, Xin, Mansour, Sahar, Manzur, Adnan, Maroofian, Reza, Marsden, Brian, Mason, Joanne, McGowan, Simon J., Mei, Davide, Mlcochova, Hana, Murakami, Yoshiko, Németh, Andrea H., Okoli, Steven, Ormondroyd, Elizabeth, Ousager, Lilian Bomme, Palace, Jacqueline, Patel, Smita Y., Pentony, Melissa M., Pugh, Chris, Rad, Aboulfazl, Ramesh, Archana, Riva, Simone G., Roberts, Irene, Roy, Noémi, Salminen, Outi, Schilling, Kyleen D., Scott, Caroline, Sen, Arjune, Smith, Conrad, Stevenson, Mark, Thakker, Rajesh V., Twigg, Stephen R. F., Uhlig, Holm H., van Wijk, Richard, Vona, Barbara, Wall, Steven, Wang, Jing, Watkins, Hugh, Zak, Jaroslav, Schuh, Anna H., Kini, Usha, Wilkie, Andrew O. M., Popitsch, Niko, Taylor, Jenny C.
Publicado 2023