Machine learning approach informs biology of cancer drug response

por Zhu, Eliot Y., Dupuy, Adam J.
Publicado 2022

Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics

por Guimaraes-Young, Amy, Feddersen, Charlotte R., Dupuy, Adam J.
Publicado 2019

Understanding cancer drug resistance with Sleeping Beauty functional genomic screens: Application to MAPK inhibition in cutaneous melanoma

por Zhu, Eliot Y., Schillo, Jacob L., Murray, Sarina D., Riordan, Jesse D., Dupuy, Adam J.
Publicado 2023

Ectopic expression of Zmiz1 induces cutaneous squamous cell malignancies in a mouse model of cancer

por Rogers, Laura M., Riordan, Jesse D., Swick, Brian L., Meyerholz, David K., Dupuy, Adam J.
Publicado 2013

Keratoacanthoma Pathobiology in Mouse Models

por Gibson-Corley, Katherine N., Rogers, Laura M., Goeken, Adam, Dupuy, Adam J., Meyerholz, David K.
Publicado 2014

Novel Molecular and Computational Methods Improve the Accuracy of Insertion Site Analysis in Sleeping Beauty-Induced Tumors

por Brett, Benjamin T., Berquam-Vrieze, Katherine E., Nannapaneni, Kishore, Huang, Jian, Scheetz, Todd E., Dupuy, Adam J.
Publicado 2011

SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas

por Zhu, Eliot Y., Riordan, Jesse D., Vanneste, Marion, Henry, Michael D., Stipp, Christopher S., Dupuy, Adam J.
Publicado 2022

A Trp53(fl/fl)Pten(fl/fl) mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging

por Buchakjian, Marisa R., Merritt, Nicole M., Moose, Devon L., Dupuy, Adam J., Tanas, Munir R., Henry, Michael D.
Publicado 2017

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis

por DeZwaan-McCabe, Diane, Riordan, Jesse D., Arensdorf, Angela M., Icardi, Michael S., Dupuy, Adam J., Rutkowski, D. Thomas
Publicado 2013

Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens

por Riordan, Jesse D, Drury, Luke J, Smith, Ryan P, Brett, Benjamin T, Rogers, Laura M, Scheetz, Todd E, Dupuy, Adam J
Publicado 2014

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

por Temiz, Nuri A., Moriarity, Branden S., Wolf, Natalie K., Riordan, Jesse D., Dupuy, Adam J., Largaespada, David A., Sarver, Aaron L.
Publicado 2016

A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells

por Feddersen, Charlotte R., Wadsworth, Lexy S., Zhu, Eliot Y., Vaughn, Hayley R., Voigt, Andrew P., Riordan, Jesse D., Dupuy, Adam J.
Publicado 2019

A comprehensive evaluation of Hippo pathway silencing in sarcomas

por Merritt, Nicole M., Fullenkamp, Colleen A., Hall, Sarah L., Qian, Qining, Desai, Chandni, Thomason, Jon, Lambertz, Allyn M., Dupuy, Adam J., Darbro, Benjamin, Tanas, Munir R.
Publicado 2018

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice

por Loeb, Keith R., Hughes, Bridget T., Fissel, Brian M., Osteen, Nyka J., Knoblaugh, Sue E., Grim, Jonathan E., Drury, Luke J., Sarver, Aaron, Dupuy, Adam J., Clurman, Bruce E.
Publicado 2019

Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis

por Vanneste, Marion, Feddersen, Charlotte R., Varzavand, Afshin, Zhu, Elliot Y., Foley, Tyler, Zhao, Lei, Holt, Kathleen H., Milhem, Mohammed, Piper, Robert, Stipp, Christopher S., Dupuy, Adam J., Henry, Michael D.
Publicado 2020

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

por Ziyad, Safiyyah, Riordan, Jesse D., Cavanaugh, Ann M., Su, Trent, Hernandez, Gloria E., Hilfenhaus, Georg, Morselli, Marco, Huynh, Kristine, Wang, Kevin, Chen, Jau-Nian, Dupuy, Adam J., Iruela-Arispe, M. Luisa
Publicado 2018

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

por Rauckhorst, Adam J., Gray, Lawrence R., Sheldon, Ryan D., Fu, Xiaorong, Pewa, Alvin D., Feddersen, Charlotte R., Dupuy, Adam J., Gibson-Corley, Katherine N., Cox, James E., Burgess, Shawn C., Taylor, Eric B.
Publicado 2017

Somatic Mutagenesis with a Sleeping Beauty Transposon System Leads to Solid Tumor Formation in Zebrafish

por McGrail, Maura, Hatler, Julia M., Kuang, Xianyan, Liao, Hsin-Kai, Nannapaneni, Kishore, Noack Watt, Kristin E., Uhl, Juli D., Largaespada, David A., Vollbrecht, Erik, Scheetz, Todd E., Dupuy, Adam J., Hostetter, Jesse M., Essner, Jeffrey J.
Publicado 2011

Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis

por Riordan, Jesse D., Keng, Vincent W., Tschida, Barbara R., Scheetz, Todd E., Bell, Jason B., Podetz-Pedersen, Kelly M., Moser, Catherine D., Copeland, Neal G., Jenkins, Nancy A., Roberts, Lewis R., Largaespada, David A., Dupuy, Adam J.
Publicado 2013

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

por Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.
Publicado 2019