Glutathione facilitates enterovirus assembly by binding at a druggable pocket

por Duyvesteyn, Helen M. E., Ren, Jingshan, Walter, Thomas S., Fry, Elizabeth E., Stuart, David I.
Publicado 2020

Switching of Receptor Binding Poses between Closely Related Enteroviruses

por Zhou, Daming, Qin, Ling, Duyvesteyn, Helen M. E., Zhao, Yuguang, Lin, Tzou-Yien, Fry, Elizabeth E., Ren, Jingshan, Huang, Kuan-Ying A., Stuart, David I.
Publicado 2022

Machining protein microcrystals for structure determination by electron diffraction

por Duyvesteyn, Helen M. E., Kotecha, Abhay, Ginn, Helen M., Hecksel, Corey W., Beale, Emma V., de Haas, Felix, Evans, Gwyndaf, Zhang, Peijun, Chiu, Wah, Stuart, David I.
Publicado 2018

Bacteriophage PRD1 as a nanoscaffold for drug loading

por Duyvesteyn, Helen M. E., Santos-Pérez, Isaac, Peccati, Francesca, Martinez-Castillo, Ane, Walter, Thomas S., Reguera, David, Goñi, Felix M., Jiménez-Osés, Gonzalo, Oksanen, Hanna M., Stuart, David I., Abrescia, Nicola G. A.
Publicado 2021

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

por Ni, Tao, Mendonça, Luiza, Zhu, Yanan, Howe, Andrew, Radecke, Julika, Shah, Pranav M., Sheng, Yuewen, Krebs, Anna-Sophia, Duyvesteyn, Helen M.E., Allen, Elizabeth, Lambe, Teresa, Bisset, Cameron, Spencer, Alexandra, Morris, Susan, Stuart, David I., Gilbert, Sarah, Zhang, Peijun
Publicado 2023

Towards in cellulo virus crystallography

por Duyvesteyn, Helen M. E., Ginn, Helen M., Pietilä, Maija K., Wagner, Armin, Hattne, Johan, Grimes, Jonathan M., Hirvonen, Elina, Evans, Gwyndaf, Parsy, Marie-Laure, Sauter, Nicholas K., Brewster, Aaron S., Huiskonen, Juha T., Stuart, David I., Sutton, Geoff, Bamford, Dennis H.
Publicado 2018

Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins

por Ebrahim, Ali, Moreno-Chicano, Tadeo, Appleby, Martin V., Chaplin, Amanda K., Beale, John H., Sherrell, Darren A., Duyvesteyn, Helen M. E., Owada, Shigeki, Tono, Kensuke, Sugimoto, Hiroshi, Strange, Richard W., Worrall, Jonathan A. R., Axford, Danny, Owen, Robin L., Hough, Michael A.
Publicado 2019

High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography

por Moreno-Chicano, Tadeo, Ebrahim, Ali, Axford, Danny, Appleby, Martin V., Beale, John H., Chaplin, Amanda K., Duyvesteyn, Helen M. E., Ghiladi, Reza A., Owada, Shigeki, Sherrell, Darren A., Strange, Richard W., Sugimoto, Hiroshi, Tono, Kensuke, Worrall, Jonathan A. R., Owen, Robin L., Hough, Michael A.
Publicado 2019

Accelerating drug target inhibitor discovery with a deep generative foundation model

por Chenthamarakshan, Vijil, Hoffman, Samuel C., Owen, C. David, Lukacik, Petra, Strain-Damerell, Claire, Fearon, Daren, Malla, Tika R., Tumber, Anthony, Schofield, Christopher J., Duyvesteyn, Helen M.E., Dejnirattisai, Wanwisa, Carrique, Loic, Walter, Thomas S., Screaton, Gavin R., Matviiuk, Tetiana, Mojsilovic, Aleksandra, Crain, Jason, Walsh, Martin A., Stuart, David I., Das, Payel
Publicado 2023

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

por Shirasaki, Takayoshi, Feng, Hui, Duyvesteyn, Helen M. E., Fusco, William G., McKnight, Kevin L., Xie, Ling, Boyce, Mark, Kumar, Sathish, Barouch-Bentov, Rina, González-López, Olga, McNamara, Ryan, Wang, Li, Hertel-Wulff, Adriana, Chen, Xian, Einav, Shirit, Duncan, Joseph A., Kapustina, Maryna, Fry, Elizabeth E., Stuart, David I., Lemon, Stanley M.
Publicado 2022

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

por Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.
Publicado 2020

Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation

por Allen, Joel D., Chawla, Himanshi, Samsudin, Firdaus, Zuzic, Lorena, Shivgan, Aishwary Tukaram, Watanabe, Yasunori, He, Wan-ting, Callaghan, Sean, Song, Ge, Yong, Peter, Brouwer, Philip J. M., Song, Yutong, Cai, Yongfei, Duyvesteyn, Helen M. E., Malinauskas, Tomas, Kint, Joeri, Pino, Paco, Wurm, Maria J., Frank, Martin, Chen, Bing, Stuart, David I., Sanders, Rogier W., Andrabi, Raiees, Burton, Dennis R., Li, Sai, Bond, Peter J., Crispin, Max
Publicado 2021

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

por Graham, Carl, Seow, Jeffrey, Huettner, Isabella, Khan, Hataf, Kouphou, Neophytos, Acors, Sam, Winstone, Helena, Pickering, Suzanne, Galao, Rui Pedro, Lista, Maria Jose, Jimenez-Guardeno, Jose M, Laing, Adam G., Wu, Yin, Joseph, Magdalene, Muir, Luke, Ng, Weng M., Duyvesteyn, Helen M. E., Zhao, Yuguang, Bowden, Thomas A., Shankar-Hari, Manu, Rosa, Annachiara, Cherepanov, Peter, McCoy, Laura E., Hayday, Adrian C., Neil, Stuart J.D., Malim, Michael H., Doores, Katie J.
Publicado 2021

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature

por Moreno-Chicano, Tadeo, Carey, Leiah M., Axford, Danny, Beale, John H., Doak, R. Bruce, Duyvesteyn, Helen M. E., Ebrahim, Ali, Henning, Robert W., Monteiro, Diana C. F., Myles, Dean A., Owada, Shigeki, Sherrell, Darren A., Straw, Megan L., Šrajer, Vukica, Sugimoto, Hiroshi, Tono, Kensuke, Tosha, Takehiko, Tews, Ivo, Trebbin, Martin, Strange, Richard W., Weiss, Kevin L., Worrall, Jonathan A. R., Meilleur, Flora, Owen, Robin L., Ghiladi, Reza A., Hough, Michael A.
Publicado 2022

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

por Huang, Kuan-Ying A., Zhou, Daming, Tan, Tiong Kit, Chen, Charles, Duyvesteyn, Helen M. E., Zhao, Yuguang, Ginn, Helen M., Qin, Ling, Rijal, Pramila, Schimanski, Lisa, Donat, Robert, Harding, Adam, Gilbert-Jaramillo, Javier, James, William, Tree, Julia A., Buttigieg, Karen, Carroll, Miles, Charlton, Sue, Lien, Chia-En, Lin, Meei-Yun, Chen, Cheng-Pin, Cheng, Shu-Hsing, Chen, Xiaorui, Lin, Tzou-Yien, Fry, Elizabeth E., Ren, Jingshan, Ma, Che, Townsend, Alain R., Stuart, David I.
Publicado 2022

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

por Graham, Carl, Seow, Jeffrey, Huettner, Isabella, Khan, Hataf, Kouphou, Neophytos, Acors, Sam, Winstone, Helena, Pickering, Suzanne, Galao, Rui Pedro, Dupont, Liane, Lista, Maria Jose, Jimenez-Guardeño, Jose M., Laing, Adam G., Wu, Yin, Joseph, Magdalene, Muir, Luke, van Gils, Marit J., Ng, Weng M., Duyvesteyn, Helen M.E., Zhao, Yuguang, Bowden, Thomas A., Shankar-Hari, Manu, Rosa, Annachiara, Cherepanov, Peter, McCoy, Laura E., Hayday, Adrian C., Neil, Stuart J.D., Malim, Michael H., Doores, Katie J.
Publicado 2021

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

por Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Publicado 2022

Rapid escape of new SARS-CoV-2 Omicron variants from BA.2-directed antibody responses

por Dijokaite-Guraliuc, Aiste, Das, Raksha, Zhou, Daming, Ginn, Helen M., Liu, Chang, Duyvesteyn, Helen M.E., Huo, Jiandong, Nutalai, Rungtiwa, Supasa, Piyada, Selvaraj, Muneeswaran, de Silva, Thushan I., Plowright, Megan, Newman, Thomas A.H., Hornsby, Hailey, Mentzer, Alexander J., Skelly, Donal, Ritter, Thomas G., Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Roemer, Cornelius, Peacock, Thomas P., Paterson, Neil G., Williams, Mark A., Hall, David R., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Publicado 2023

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

por Huo, Jiangdong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.
Publicado 2020

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

por Huo, Jiandong, Bas, Audrey Le, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.
Publicado 2021