Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair

por Prasad, Rajendra, Dyrkheeva, Nadezhda, Williams, Jason, Wilson, Samuel H.
Publicado 2015

Capturing Snapshots of APE1 Processing DNA Damage

por Freudenthal, Bret D., Beard, William A., Cuneo, Matthew J., Dyrkheeva, Nadezhda S., Wilson, Samuel H.
Publicado 2015

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols

por Dyrkheeva, Nadezhda, Anarbaev, Rashid, Lebedeva, Natalia, Kuprushkin, Maxim, Kuznetsova, Alexandra, Kuznetsov, Nikita, Rechkunova, Nadejda, Lavrik, Olga
Publicado 2020

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1

por Zakharenko, Alexandra L., Luzina, Olga A., Chepanova, Arina A., Dyrkheeva, Nadezhda S., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2023

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

por Zakharenko, Alexandra L., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Ivanov, Georgy A., Oslovsky, Vladimir E., Ilina, Ekaterina S., Chernyshova, Irina A., Lavrik, Olga I., Mikhailov, Sergey N.
Publicado 2020

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

por Komarova, Anastasia O., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Kulikova, Irina V., Oslovsky, Vladimir E., Zakharova, Olga D., Zakharenko, Alexandra L., Mikhailov, Sergey N., Lavrik, Olga I.
Publicado 2018

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents

por Zakharenko, Alexandra L., Dyrkheeva, Nadezhda S., Luzina, Olga A., Filimonov, Aleksandr S., Mozhaitsev, Evgenii S., Malakhova, Anastasia A., Medvedev, Sergey P., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2023

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2

por Salomatina, Oksana V., Dyrkheeva, Nadezhda S., Popadyuk, Irina I., Zakharenko, Alexandra L., Ilina, Ekaterina S., Komarova, Nina I., Reynisson, Jóhannes, Salakhutdinov, Nariman F., Lavrik, Olga I., Volcho, Konstantin P.
Publicado 2021

Cas9 is mostly orthogonal to human systems of DNA break sensing and repair

por Maltseva, Ekaterina A., Vasil’eva, Inna A., Moor, Nina A., Kim, Daria V., Dyrkheeva, Nadezhda S., Kutuzov, Mikhail M., Vokhtantsev, Ivan P., Kulishova, Lilya M., Zharkov, Dmitry O., Lavrik, Olga I.
Publicado 2023

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition

por Dyrkheeva, Nadezhda S., Filimonov, Aleksandr S., Luzina, Olga A., Zakharenko, Alexandra L., Ilina, Ekaterina S., Malakhova, Anastasia A., Medvedev, Sergey P., Reynisson, Jóhannes, Volcho, Konstantin P., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2021

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties

por Ivankin, Dmitry I., Kornienko, Tatyana E., Mikhailova, Marina A., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Achara, Chigozie, Reynisson, Jóhannes, Golyshev, Victor M., Luzina, Olga A., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2023

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistr...

por Dyrkheeva, Nadezhda S., Chernyshova, Irina A., Ivanov, Georgy A., Porozov, Yuri B., Zenchenko, Anastasia A., Oslovsky, Vladimir E., Zakharenko, Alexandra L., Nasyrova, Darina I., Likhatskaya, Galina N., Mikhailov, Sergey N., Lavrik, Olga I., Drenichev, Mikhail S.
Publicado 2022

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan

por Khomenko, Tatyana M., Zakharenko, Alexandra L., Kornienko, Tatyana E., Chepanova, Arina A., Dyrkheeva, Nadezhda S., Artemova, Anastasia O., Korchagina, Dina V., Achara, Chigozie, Curtis, Anthony, Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2023

DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling

por Krumkacheva, Olesya A, Shevelev, Georgiy Yu, Lomzov, Alexander A, Dyrkheeva, Nadezhda S, Kuzhelev, Andrey A, Koval, Vladimir V, Tormyshev, Victor M, Polienko, Yuliya F, Fedin, Matvey V, Pyshnyi, Dmitrii V, Lavrik, Olga I, Bagryanskaya, Elena G
Publicado 2019

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments

por Munkuev, Aldar A., Mozhaitsev, Evgenii S., Chepanova, Arina A., Suslov, Evgeniy V., Korchagina, Dina V., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Zakharenko, Alexandra L., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2021

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo

por Chernyshova, Irina A., Zakharenko, Aleksandra L., Kurochkin, Nikolay N., Dyrkheeva, Nadezhda S., Kornienko, Tatyana E., Popova, Nelly A., Nikolin, Valeriy P., Ilina, Ekaterina S., Zharkov, Timofey D., Kupryushkin, Maxim S., Oslovsky, Vladimir E., Drenichev, Mikhail S., Lavrik, Olga I.
Publicado 2022

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

por Gladkova, Elizaveta D., Nechepurenko, Ivan V., Bredikhin, Roman A., Chepanova, Arina A., Zakharenko, Alexandra L., Luzina, Olga A., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Mamontova, Evgeniya M., Anarbaev, Rashid O., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2020

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan

por Munkuev, Aldar A., Dyrkheeva, Nadezhda S., Kornienko, Tatyana E., Ilina, Ekaterina S., Ivankin, Dmitry I., Suslov, Evgeniy V., Korchagina, Dina V., Gatilov, Yuriy V., Zakharenko, Alexandra L., Malakhova, Anastasia A., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2022

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

por Dyrkheeva, Nadezhda S., Malakhova, Anastasia A., Zakharenko, Aleksandra L., Okorokova, Larisa S., Shtokalo, Dmitriy N., Pavlova, Sophia V., Medvedev, Sergey P., Zakian, Suren M., Nushtaeva, Anna A., Tupikin, Alexey E., Kabilov, Marsel R., Khodyreva, Svetlana N., Luzina, Olga A., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2023

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

por Filimonov, Aleksander S., Chepanova, Arina A., Luzina, Olga A., Zakharenko, Alexandra L., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Kuprushkin, Maxim S., Kolotaev, Anton V., Khachatryan, Derenik S., Patel, Jinal, Leung, Ivanhoe K.H., Chand, Raina, Ayine-Tora, Daniel M., Reynisson, Johannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2019