The Urokinase Receptor (uPAR) as a “Trojan Horse” in Targeted Cancer Therapy: Challenges and Opportunities

por Metrangolo, Virginia, Ploug, Michael, Engelholm, Lars H.
Publicado 2021

The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

por MELANDER, MARIA C., JÜRGENSEN, HENRIK J., MADSEN, DANIEL H., ENGELHOLM, LARS H., BEHRENDT, NIELS
Publicado 2015

Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo

por Lund, Ida K., Rasch, Morten G., Ingvarsen, Signe, Pass, Jesper, Madsen, Daniel H., Engelholm, Lars H., Behrendt, Niels, Høyer-Hansen, Gunilla
Publicado 2012

CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets()

por Jürgensen, Henrik J., Silva, Lakmali M., Krigslund, Oliver, van Putten, Sander, Madsen, Daniel H., Behrendt, Niels, Engelholm, Lars H., Bugge, Thomas H.
Publicado 2019

Uncovering mediators of collagen degradation in the tumor microenvironment

por Thorseth, Marie-Louise, Carretta, Marco, Jensen, Christina, Mølgaard, Kasper, Jürgensen, Henrik J., Engelholm, Lars H., Behrendt, Niels, Willumsen, Nicholas, Madsen, Daniel H.
Publicado 2022

Loss of miR-10a Activates Lpo and Collaborates with Activated Wnt Signaling in Inducing Intestinal Neoplasia in Female Mice

por Stadthagen, Gustavo, Tehler, Disa, Høyland-Kroghsbo, Nina Molin, Wen, Jiayu, Krogh, Anders, Jensen, Klaus T., Santoni-Rugiu, Eric, Engelholm, Lars H., Lund, Anders H.
Publicado 2013

The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target

por Çakılkaya, Pınar, Sørensen, Rikke Raagaard, Jürgensen, Henrik Jessen, Krigslund, Oliver, Gårdsvoll, Henrik, Nielsen, Christoffer F., Santoni-Rugiu, Eric, Behrendt, Niels, Engelholm, Lars H.
Publicado 2021

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

por Curino, Alejandro C., Engelholm, Lars H., Yamada, Susan S., Holmbeck, Kenn, Lund, Leif R., Molinolo, Alfredo A., Behrendt, Niels, Nielsen, Boye Schnack, Bugge, Thomas H.
Publicado 2005

Differential Actions of the Endocytic Collagen Receptor uPARAP/Endo180 and the Collagenase MMP-2 in Bone Homeostasis

por Madsen, Daniel H., Jürgensen, Henrik J., Ingvarsen, Signe, Melander, Maria C., Albrechtsen, Reidar, Hald, Andreas, Holmbeck, Kenn, Bugge, Thomas H., Behrendt, Niels, Engelholm, Lars H.
Publicado 2013

No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer

por Cramer, Elisabeth P., Glenthøj, Andreas, Häger, Mattias, Juncker-Jensen, Anna, Engelholm, Lars H., Santoni-Rugiu, Eric, Lund, Leif R., Laerum, Ole D., Cowland, Jack B., Borregaard, Niels
Publicado 2012

Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

por Jürgensen, Henrik J., Nørregaard, Kirstine S., Sibree, Megan M., Santoni-Rugiu, Eric, Madsen, Daniel H., Wassilew, Katharina, Krustrup, Dorrit, Garred, Peter, Bugge, Thomas H., Engelholm, Lars H., Behrendt, Niels
Publicado 2019

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

por Rowe, R. Grant, Li, Xiao-Yan, Hu, Yuexian, Saunders, Thomas L., Virtanen, Ismo, de Herreros, Antonio Garcia, Becker, Karl-Friedrich, Ingvarsen, Signe, Engelholm, Lars H., Bommer, Guido T., Fearon, Eric R., Weiss, Stephen J.
Publicado 2009

Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

por Ingvarsen, Signe Z., Gårdsvoll, Henrik, van Putten, Sander, Nørregaard, Kirstine S., Krigslund, Oliver, Meilstrup, Josephine A., Tran, Collin, Jürgensen, Henrik J., Melander, Maria C., Nielsen, Carsten H., Kjaer, Andreas, Bugge, Thomas H., Engelholm, Lars H., Behrendt, Niels
Publicado 2020

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

por Engelholm, Lars H., List, Karin, Netzel-Arnett, Sarah, Cukierman, Edna, Mitola, David J., Aaronson, Hannah, Kjøller, Lars, Larsen, Jørgen K., Yamada, Kenneth M., Strickland, Dudley K., Holmbeck, Kenn, Danø, Keld, Birkedal-Hansen, Henning, Behrendt, Niels, Bugge, Thomas H.
Publicado 2003

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

por Madsen, Daniel H., Leonard, Daniel, Masedunskas, Andrius, Moyer, Amanda, Jürgensen, Henrik Jessen, Peters, Diane E., Amornphimoltham, Panomwat, Selvaraj, Arul, Yamada, Susan S., Brenner, David A., Burgdorf, Sven, Engelholm, Lars H., Behrendt, Niels, Holmbeck, Kenn, Weigert, Roberto, Bugge, Thomas H.
Publicado 2013

Collagen density regulates the activity of tumor-infiltrating T cells

por Kuczek, Dorota E., Larsen, Anne Mette H., Thorseth, Marie-Louise, Carretta, Marco, Kalvisa, Adrija, Siersbæk, Majken S., Simões, Ana Micaela C., Roslind, Anne, Engelholm, Lars H., Noessner, Elfriede, Donia, Marco, Svane, Inge Marie, Straten, Per thor, Grøntved, Lars, Madsen, Daniel H.
Publicado 2019