The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target()

por Eadsforth, Thomas C., Cameron, Scott, Hunter, William N.
Publicado 2012

Structure of the SCAN Domain of Human Paternally Expressed Gene 3 Protein

por Rimsa, Vadim, Eadsforth, Thomas C., Hunter, William N.
Publicado 2013

Two high-resolution structures of the human E3 ubiquitin ligase Siah1

por Rimsa, Vadim, Eadsforth, Thomas C., Hunter, William N.
Publicado 2013

High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies

por Rimsa, Vadim, Eadsforth, Thomas C., Joosten, Robbie P., Hunter, William N.
Publicado 2014

Pseudomonas aeruginosa 4-Amino-4-Deoxychorismate Lyase: Spatial Conservation of an Active Site Tyrosine and Classification of Two Types of Enzyme

por O'Rourke, Patrick E. F., Eadsforth, Thomas C., Fyfe, Paul K., Shepherd, Sharon M., Hunter, William N.
Publicado 2011

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

por Morgan, Rachel E, Batot, Gaëlle O, Dement, Jennifer M, Rao, Vincenzo A, Eadsforth, Thomas C, Hunter, William N
Publicado 2011

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

por Prakash, Ohm, Führing, Jana, Post, John, Shepherd, Sharon M., Eadsforth, Thomas C., Gray, David, Fedorov, Roman, Routier, Françoise H.
Publicado 2019

Assessment of Pseudomonas aeruginosa N (5),N (10)-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

por Eadsforth, Thomas C., Gardiner, Mary, Maluf, Fernando V., McElroy, Stuart, James, Daniel, Frearson, Julie, Gray, David, Hunter, William N.
Publicado 2012

Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination

por Bisson, Claudine, Britton, K. Linda, Sedelnikova, Svetlana E., Rodgers, H. Fiona, Eadsforth, Thomas C., Viner, Russell C., Hawkes, Tim R., Baker, Patrick J., Rice, David W.
Publicado 2015

Mirror‐Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide

por Bisson, Claudine, Britton, K. Linda, Sedelnikova, Svetlana E., Rodgers, H. Fiona, Eadsforth, Thomas C., Viner, Russell C., Hawkes, Tim R., Baker, Patrick J., Rice, David W.
Publicado 2016

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

por Eadsforth, Thomas C., Pinto, Andrea, Luciani, Rosaria, Tamborini, Lucia, Cullia, Gregorio, De Micheli, Carlo, Marinelli, Luciana, Cosconati, Sandro, Novellino, Ettore, Lo Presti, Leonardo, Cordeiro da Silva, Anabela, Conti, Paola, Hunter, William N., Costi, Maria P.
Publicado 2015

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity

por Green, Simon R., Wilson, Caroline, Eadsforth, Thomas C., Punekar, Avinash S., Tamaki, Fabio K., Wood, Gavin, Caldwell, Nicola, Forte, Barbara, Norcross, Neil R., Kiczun, Michael, Post, John M., Lopez-Román, Eva Maria, Engelhart, Curtis A., Lukac, Iva, Zuccotto, Fabio, Epemolu, Ola, Boshoff, Helena I. M., Schnappinger, Dirk, Walpole, Chris, Gilbert, Ian H., Read, Kevin D., Wyatt, Paul G., Baragaña, Beatriz
Publicado 2023