Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide

por Li, Yangmei, Eans, Shainnel O., Ganno-Sherwood, Michelle, Eliasof, Abbe, Houghten, Richard A., McLaughlin, Jay P.
Publicado 2023

Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice

por Spetea, Mariana, Eans, Shainnel O, Ganno, Michelle L, Lantero, Aquilino, Mairegger, Michael, Toll, Lawrence, Schmidhammer, Helmut, McLaughlin, Jay P
Publicado 2017

Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use

por Wilson, Lisa L., Eans, Shainnel O., Ramadan-Siraj, Insitar, Modica, Maria N., Romeo, Giuseppe, Intagliata, Sebastiano, McLaughlin, Jay P.
Publicado 2022

Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration

por Rayala, Ramanjaneyulu, Tiller, Annika, Majumder, Shahayra A., Stacy, Heather M., Eans, Shainnel O., Nedovic, Aleksandra, McLaughlin, Jay P., Cudic, Predrag
Publicado 2023

Nonpeptide Small Molecule Agonist and Antagonist Original Leads for Neuropeptide FF1 and FF2 Receptors

por Journigan, V. Blair, Mésangeau, Christophe, Vyas, Neha, Eans, Shainnel O., Cutler, Stephen J., McLaughlin, Jay P., Mollereau, Catherine, McCurdy, Christopher R.
Publicado 2014

Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Ex...

por Scherrer, Kristen H., Eans, Shainnel O., Medina, Jessica M., Senadheera, Sanjeewa N., Khaliq, Tanvir, Murray, Thomas F., McLaughlin, Jay P., Aldrich, Jane V.
Publicado 2023

Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

por Cirino, Thomas J., Eans, Shainnel O., Medina, Jessica M., Wilson, Lisa L., Mottinelli, Marco, Intagliata, Sebastiano, McCurdy, Christopher R., McLaughlin, Jay P.
Publicado 2019

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics

por McLaughlin, Jay P., Rayala, Ramanjaneyulu, Bunnell, Ashley J., Tantak, Mukund P., Eans, Shainnel O., Nefzi, Khadija, Ganno, Michelle L., Dooley, Colette T., Nefzi, Adel
Publicado 2022

A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications

por Wang, Yi, Eans, Shainnel O., Stacy, Heather M., Narayanapillai, Sreekanth C., Sharma, Abhisheak, Fujioka, Naomi, Haddad, Linda, McLaughlin, Jay, Avery, Bonnie A., Xing, Chengguo
Publicado 2018

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

por Brice-Tutt, Ariana C., Senadheera, Sanjeewa N., Ganno, Michelle L., Eans, Shainnel O., Khaliq, Tanvir, Murray, Thomas F., McLaughlin, Jay P., Aldrich, Jane V.
Publicado 2020

Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain

por Wilson, Lisa L., Alleyne, Amy R., Eans, Shainnel O., Cirino, Thomas J., Stacy, Heather M., Mottinelli, Marco, Intagliata, Sebastiano, McCurdy, Christopher R., McLaughlin, Jay P.
Publicado 2022

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

por Houghten, Richard A., Ganno, Michelle L., McLaughlin, Jay P., Dooley, Colette T., Eans, Shainnel O., Santos, Radleigh G., LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A., Toll, Lawrence
Publicado 2015

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity

por Norwood, Verrill M., Brice-Tutt, Ariana C., Eans, Shainnel O., Stacy, Heather M., Shi, Guqin, Ratnayake, Ranjala, Rocca, James R., Abboud, Khalil A., Li, Chenglong, Luesch, Hendrik, McLaughlin, Jay P., Huigens, Robert W.
Publicado 2020

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

por Uprety, Rajendra, Che, Tao, Zaidi, Saheem A, Grinnell, Steven G, Varga, Balázs R, Faouzi, Abdelfattah, Slocum, Samuel T, Allaoa, Abdullah, Varadi, András, Nelson, Melissa, Bernhard, Sarah M, Kulko, Elizaveta, Le Rouzic, Valerie, Eans, Shainnel O, Simons, Chloe A, Hunkele, Amanda, Subrath, Joan, Pan, Ying Xian, Javitch, Jonathan A, McLaughlin, Jay P, Roth, Bryan L, Pasternak, Gavril W, Katritch, Vsevolod, Majumdar, Susruta
Publicado 2021