Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

por Sindhe, Kirthana M. V., Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E., Cooper, Roland A., Plattner, Jacob J., Freund, Yvonne R., DeRisi, Joseph L., Rosenthal, Philip J.
Publicado 2020

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

por Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Jacobs, Robert T., Guo, Denghui, Sanders, Virginia, Freund, Yvonne R., Campo, Brice, Rosenthal, Philip J., Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Liang, Ding, Jie, Yang, Yin
Publicado 2015

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

por Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Publicado 2018

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

por Carter, David S., Jacobs, Robert T., Freund, Yvonne R., Berry, Pamela W., Akama, Tsutomu, Easom, Eric E., Lunde, Christopher S., Rock, Fernando, Stefanakis, Rianna, McKerrow, James, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Sakanari, Judy A., Lustigman, Sara, Plattner, Jacob J.
Publicado 2019

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs

por Akama, Tsutomu, Freund, Yvonne R., Berry, Pamela W., Carter, David S., Easom, Eric E., Jarnagin, Kurt, Lunde, Christopher S., Plattner, Jacob J., Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Mansour, Abdelmoneim, DiCosty, Utami, McCall, Scott, Carson, Ben, McCall, John W., McKerrow, James, Hübner, Marc P., Specht, Sabine, Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A., Jacobs, Robert T.
Publicado 2019

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

por Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z., Easom, Eric E., Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L., Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G., Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J., O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B., Waters, M. Gerard, Ma, Zhenkun, Ioerger, Thomas R., Sacchettini, James C., Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J., Alley, M. R. K.
Publicado 2016