A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

por KalantarMotamedi, Yasaman, Eastman, Richard T., Guha, Rajarshi, Bender, Andreas
Publicado 2018

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers

por Eastman, Richard T., Khine, Pwint, Huang, Ruili, Thomas, Craig J., Su, Xin-zhuan
Publicado 2016

Using Machine Learning to Predict Synergistic Antimalarial Compound Combinations With Novel Structures

por Mason, Daniel J., Eastman, Richard T., Lewis, Richard P. I., Stott, Ian P., Guha, Rajarshi, Bender, Andreas
Publicado 2018

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

por Eastman, Richard T., Roth, Jacob S., Brimacombe, Kyle R., Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D.
Publicado 2020

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19

por Eastman, Richard T., Roth, Jacob S., Brimacombe, Kyle R., Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D.
Publicado 2020

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

por Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.
Publicado 2020

Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay

por Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.
Publicado 2020

Deep learning identifies synergistic drug combinations for treating COVID-19

por Jin, Wengong, Stokes, Jonathan M., Eastman, Richard T., Itkin, Zina, Zakharov, Alexey V., Collins, James J., Jaakkola, Tommi S., Barzilay, Regina
Publicado 2021

Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules

por Martin, Holli-Joi, Melo-Filho, Cleber C., Korn, Daniel, Eastman, Richard T., Rai, Ganesha, Simeonov, Anton, Zakharov, Alexey V., Muratov, Eugene, Tropsha, Alexander
Publicado 2022

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation

por Lemieux, Jacob E, Kyes, Sue A, Otto, Thomas D, Feller, Avi I, Eastman, Richard T, Pinches, Robert A, Berriman, Matthew, Su, Xin-zhuan, Newbold, Chris I
Publicado 2013

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model

por Lacerda-Queiroz, Norinne, Riteau, Nicolas, Eastman, Richard T., Bock, Kevin W., Orandle, Marlene S., Moore, Ian N., Sher, Alan, Long, Carole A., Jankovic, Dragana, Su, Xin-zhuan
Publicado 2017

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

por Dorjsuren, Dorjbal, Eastman, Richard T., Song, Min Jae, Yasgar, Adam, Chen, Yuchi, Bharti, Kapil, Zakharov, Alexey V., Jadhav, Ajit, Ferrer, Marc, Shi, Pei-Yong, Simeonov, Anton
Publicado 2022

Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children

por Kasule, Jingo, Gabriel, Erin E., Anok, Aggrey, Neal, Jillian, Eastman, Richard T., Penzak, Scott, Newell, Kevin, Serwadda, David, Duffy, Patrick E., Reynolds, Steven J., Hobbs, Charlotte V.
Publicado 2018

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

por Bobrowski, Tesia, Chen, Lu, Eastman, Richard T., Itkin, Zina, Shinn, Paul, Chen, Catherine, Guo, Hui, Zheng, Wei, Michael, Sam, Simeonov, Anton, Hall, Matthew D., Zakharov, Alexey V., Muratov, Eugene N.
Publicado 2020

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

por Bobrowski, Tesia, Chen, Lu, Eastman, Richard T., Itkin, Zina, Shinn, Paul, Chen, Catherine Z., Guo, Hui, Zheng, Wei, Michael, Sam, Simeonov, Anton, Hall, Matthew D., Zakharov, Alexey V., Muratov, Eugene N.
Publicado 2021

Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA

por Qi, Yanwei, Zhu, Feng, Eastman, Richard T., Fu, Young, Zilversmit, Martine, Pattaradilokrat, Sittiporn, Hong, Lingxian, Liu, Shengfa, McCutchan, Thomas F., Pan, Weiqing, Xu, Wenyue, Li, Jian, Huang, Fusheng, Su, Xin-zhuan
Publicado 2015

A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation

por Breglio, Kimberly F., Amato, Roberto, Eastman, Richard, Lim, Pharath, Sa, Juliana M., Guha, Rajarshi, Ganesan, Sundar, Dorward, David W., Klumpp-Thomas, Carleen, McKnight, Crystal, Fairhurst, Rick M., Roberts, David, Thomas, Craig, Simon, Anna Katharina
Publicado 2018

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

por Eastman, Richard T., Rusinova, Radda, Herold, Karl F., Huang, Xi-Ping, Dranchak, Patricia, Voss, Ty C., Rana, Sandeep, Shrimp, Jonathan H., White, Alex D., Hemmings, Hugh C., Roth, Bryan L., Inglese, James, Andersen, Olaf S., Dahlin, Jayme L.
Publicado 2023

Plasmodium genetic loci linked to host cytokine and chemokine responses

por Pattaradilokrat, Sittiporn, Li, Jian, Wu, Jian, Qi, Yanwei, Eastman, Richard T., Zilversmit, Martine, Nair, Sethu C., Huaman, Maria Cecilia, Quinones, Mariam, Jiang, Hongying, Li, Na, Zhu, Jun, Zhao, Keji, Kaneko, Osamu, Long, Carole A., Su, Xin-zhuan
Publicado 2014

mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening

por Chen, Lu, Wilson, Kelli, Goldlust, Ian, Mott, Bryan T., Eastman, Richard, Davis, Mindy I., Zhang, Xiaohu, McKnight, Crystal, Klumpp-Thomas, Carleen, Shinn, Paul, Simmons, John, Gormally, Mike, Michael, Sam, Thomas, Craig J., Ferrer, Marc, Guha, Rajarshi
Publicado 2016