Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

por Moosmayer, Dieter, Hilpmann, André, Hoffmann, Jutta, Schnirch, Lennart, Zimmermann, Katja, Badock, Volker, Furst, Laura, Eaton, John K., Viswanathan, Vasanthi S., Schreiber, Stuart L., Gradl, Stefan, Hillig, Roman C.
Publicado 2021

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

por Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T.
Publicado 2017

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

por Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.
Publicado 2019