Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment

por Abdelnabi, Rana, Jochmans, Dirk, Donckers, Kim, Trüeb, Bettina, Ebert, Nadine, Weynand, Birgit, Thiel, Volker, Neyts, Johan
Publicado 2023

Sequential Conformational Changes in the Morbillivirus Attachment Protein Initiate the Membrane Fusion Process

por Ader-Ebert, Nadine, Khosravi, Mojtaba, Herren, Michael, Avila, Mislay, Alves, Lisa, Bringolf, Fanny, Örvell, Claes, Langedijk, Johannes P., Zurbriggen, Andreas, Plemper, Richard K., Plattet, Philippe
Publicado 2015

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)

por Trimpert, Jakob, Adler, Julia M., Eschke, Kathrin, Abdelgawad, Azza, Firsching, Theresa C., Ebert, Nadine, Thao, Tran Thi Nhu, Gruber, Achim D., Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan
Publicado 2021

N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition

por Pan, Ruangang, Kindler, Eveline, Cao, Liu, Zhou, Yu, Zhang, Zhen, Liu, Qianyun, Ebert, Nadine, Züst, Roland, Sun, Ying, Gorbalenya, Alexander E., Perlman, Stanley, Thiel, Volker, Chen, Yu, Guo, Deyin
Publicado 2022

Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus

por Gultom, Mitra, Kratzel, Annika, Portmann, Jasmine, Stalder, Hanspeter, Chanfon Bätzner, Astrid, Gantenbein, Hans, Gurtner, Corinne, Ebert, Nadine, Gad, Hans Henrik, Hartmann, Rune, Posthaus, Horst, Zanolari, Patrik, Pfaender, Stephanie, Thiel, Volker, Dijkman, Ronald
Publicado 2022

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

por V'kovski, Philip, Gerber, Markus, Kelly, Jenna, Pfaender, Stephanie, Ebert, Nadine, Braga Lagache, Sophie, Simillion, Cedric, Portmann, Jasmine, Stalder, Hanspeter, Gaschen, Véronique, Bruggmann, Rémy, Stoffel, Michael H, Heller, Manfred, Dijkman, Ronald, Thiel, Volker
Publicado 2019

Reverse Genetic Assessment of the Roles Played by the Spike Protein and ORF3 in Porcine Epidemic Diarrhea Virus Pathogenicity

por Kristen-Burmann, Claudia, Rogger, Peter, Veiga, Inês Berenguer, Riebesehl, Stefanie, Rappe, Julie, Ebert, Nadine, Sautter, Carmen A., Kelly, Jenna N., Stalder, Hanspeter, Ehmann, Rosina, Huber, Michael, Posthaus, Horst, Ruggli, Nicolas, Thiel, Volker, Tekes, Gergely
Publicado 2023

Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols

por Kratzel, Annika, Todt, Daniel, V’kovski, Philip, Steiner, Silvio, Gultom, Mitra, Thao, Tran Thi Nhu, Ebert, Nadine, Holwerda, Melle, Steinmann, Jörg, Niemeyer, Daniela, Dijkman, Ronald, Kampf, Günter, Drosten, Christian, Steinmann, Eike, Thiel, Volker, Pfaender, Stephanie
Publicado 2020

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

por Kratzel, Annika, Kelly, Jenna N., V’kovski, Philip, Portmann, Jasmine, Brüggemann, Yannick, Todt, Daniel, Ebert, Nadine, Shrestha, Neeta, Plattet, Philippe, Staab-Weijnitz, Claudia A., von Brunn, Albrecht, Steinmann, Eike, Dijkman, Ronald, Zimmer, Gert, Pfaender, Stephanie, Thiel, Volker
Publicado 2021

The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor

por García-Nicolás, Obdulio, V'kovski, Philip, Vielle, Nathalie J., Ebert, Nadine, Züst, Roland, Portmann, Jasmine, Stalder, Hanspeter, Gaschen, Véronique, Vieyres, Gabrielle, Stoffel, Michael, Schweizer, Matthias, Summerfield, Artur, Engler, Olivier, Pietschmann, Thomas, Todt, Daniel, Alves, Marco P., Thiel, Volker, Pfaender, Stephanie
Publicado 2018

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding

por Trimpert, Jakob, Dietert, Kristina, Firsching, Theresa C., Ebert, Nadine, Thi Nhu Thao, Tran, Vladimirova, Daria, Kaufer, Susanne, Labroussaa, Fabien, Abdelgawad, Azza, Conradie, Andelé, Höfler, Thomas, Adler, Julia M., Bertzbach, Luca D., Jores, Joerg, Gruber, Achim D., Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan
Publicado 2021

Impaired immune response drives age-dependent severity of COVID-19

por Beer, Julius, Crotta, Stefania, Breithaupt, Angele, Ohnemus, Annette, Becker, Jan, Sachs, Benedikt, Kern, Lisa, Llorian, Miriam, Ebert, Nadine, Labroussaa, Fabien, Nhu Thao, Tran Thi, Trueeb, Bettina Salome, Jores, Joerg, Thiel, Volker, Beer, Martin, Fuchs, Jonas, Kochs, Georg, Wack, Andreas, Schwemmle, Martin, Schnepf, Daniel
Publicado 2022

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

por V’kovski, Philip, Gultom, Mitra, Kelly, Jenna N., Steiner, Silvio, Russeil, Julie, Mangeat, Bastien, Cora, Elisa, Pezoldt, Joern, Holwerda, Melle, Kratzel, Annika, Laloli, Laura, Wider, Manon, Portmann, Jasmine, Tran, Thao, Ebert, Nadine, Stalder, Hanspeter, Hartmann, Rune, Gardeux, Vincent, Alpern, Daniel, Deplancke, Bart, Thiel, Volker, Dijkman, Ronald
Publicado 2021

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

por Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K., De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen
Publicado 2023

LY6E impairs coronavirus fusion and confers immune control of viral disease

por Pfaender, Stephanie, Mar, Katrina B., Michailidis, Eleftherios, Kratzel, Annika, Boys, Ian N., V`kovski, Philip, Fan, Wenchun, Kelly, Jenna N., Hirt, Dagny, Ebert, Nadine, Stalder, Hanspeter, Kleine-Weber, Hannah, Hoffmann, Markus, Hoffmann, H. Heinrich, Saeed, Mohsan, Dijkman, Ronald, Steinmann, Eike, Wight-Carter, Mary, McDougal, Matthew B., Hanners, Natasha W., Pöhlmann, Stefan, Gallagher, Tom, Todt, Daniel, Zimmer, Gert, Rice, Charles M., Schoggins, John W., Thiel, Volker
Publicado 2020

Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2

por Gultom, Mitra, Licheri, Matthias, Laloli, Laura, Wider, Manon, Strässle, Marina, V’kovski, Philip, Steiner, Silvio, Kratzel, Annika, Thao, Tran Thi Nhu, Probst, Lukas, Stalder, Hanspeter, Portmann, Jasmine, Holwerda, Melle, Ebert, Nadine, Stokar-Regenscheit, Nadine, Gurtner, Corinne, Zanolari, Patrik, Posthaus, Horst, Schuller, Simone, Vicente-Santos, Amanda, Moreira-Soto, Andres, Corrales-Aguilar, Eugenia, Ruggli, Nicolas, Tekes, Gergely, von Messling, Veronika, Sawatsky, Bevan, Thiel, Volker, Dijkman, Ronald
Publicado 2021

Replication and single-cycle delivery of SARS-CoV-2 replicons

por Ricardo-Lax, Inna, Luna, Joseph M., Thao, Tran Thi Nhu, Le Pen, Jérémie, Yu, Yingpu, Hoffmann, H.-Heinrich, Schneider, William M., Razooky, Brandon S., Fernandez-Martinez, Javier, Schmidt, Fabian, Weisblum, Yiska, Trüeb, Bettina Salome, Berenguer Veiga, Inês, Schmied, Kimberly, Ebert, Nadine, Michailidis, Eleftherios, Peace, Avery, Sánchez-Rivera, Francisco J., Lowe, Scott W., Rout, Michael P., Hatziioannou, Theodora, Bieniasz, Paul D., Poirier, John T., MacDonald, Margaret R., Thiel, Volker, Rice, Charles M.
Publicado 2021

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

por Zhou, Bin, Thao, Tran Thi Nhu, Hoffmann, Donata, Taddeo, Adriano, Ebert, Nadine, Labroussaa, Fabien, Pohlmann, Anne, King, Jacqueline, Portmann, Jasmine, Halwe, Nico Joel, Ulrich, Lorenz, Trüeb, Bettina Salome, Kelly, Jenna N., Fan, Xiaoyu, Hoffmann, Bernd, Steiner, Silvio, Wang, Li, Thomann, Lisa, Lin, Xudong, Stalder, Hanspeter, Pozzi, Berta, de Brot, Simone, Jiang, Nannan, Cui, Dan, Hossain, Jaber, Wilson, Malania, Keller, Matthew, Stark, Thomas J., Barnes, John R., Dijkman, Ronald, Jores, Joerg, Benarafa, Charaf, Wentworth, David E., Thiel, Volker, Beer, Martin
Publicado 2020

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

por Ulrich, Lorenz, Halwe, Nico Joel, Taddeo, Adriano, Ebert, Nadine, Schön, Jacob, Devisme, Christelle, Trüeb, Bettina Salome, Hoffmann, Bernd, Wider, Manon, Fan, Xiaoyu, Bekliz, Meriem, Essaidi-Laziosi, Manel, Schmidt, Marie Luisa, Niemeyer, Daniela, Corman, Victor Max, Kraft, Anna, Godel, Aurélie, Laloli, Laura, Kelly, Jenna N., Calderon, Brenda M., Breithaupt, Angele, Wylezich, Claudia, Berenguer Veiga, Inês, Gultom, Mitra, Osman, Sarah, Zhou, Bin, Adea, Kenneth, Meyer, Benjamin, Eberhardt, Christiane S., Thomann, Lisa, Gsell, Monika, Labroussaa, Fabien, Jores, Jörg, Summerfield, Artur, Drosten, Christian, Eckerle, Isabella Anne, Wentworth, David E., Dijkman, Ronald, Hoffmann, Donata, Thiel, Volker, Beer, Martin, Benarafa, Charaf
Publicado 2021

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

por Barut, G. Tuba, Halwe, Nico Joel, Taddeo, Adriano, Kelly, Jenna N., Schön, Jacob, Ebert, Nadine, Ulrich, Lorenz, Devisme, Christelle, Steiner, Silvio, Trüeb, Bettina Salome, Hoffmann, Bernd, Veiga, Inês Berenguer, Leborgne, Nathan Georges François, Moreira, Etori Aguiar, Breithaupt, Angele, Wylezich, Claudia, Höper, Dirk, Wernike, Kerstin, Godel, Aurélie, Thomann, Lisa, Flück, Vera, Stalder, Hanspeter, Brügger, Melanie, Esteves, Blandina I. Oliveira, Zumkehr, Beatrice, Beilleau, Guillaume, Kratzel, Annika, Schmied, Kimberly, Ochsenbein, Sarah, Lang, Reto M., Wider, Manon, Machahua, Carlos, Dorn, Patrick, Marti, Thomas M., Funke-Chambour, Manuela, Rauch, Andri, Widera, Marek, Ciesek, Sandra, Dijkman, Ronald, Hoffmann, Donata, Alves, Marco P., Benarafa, Charaf, Beer, Martin, Thiel, Volker
Publicado 2022