Bisphosphonate use in the horse: what is good and what is not?

por Mitchell, Alexis, Watts, Ashlee E., Ebetino, Frank H., Suva, Larry J.
Publicado 2019

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

por Coffman, Abigail A, Basta‐Pljakic, Jelena, Guerra, Rosa M, Ebetino, Frank H, Lundy, Mark W, Majeska, Robert J, Schaffler, Mitchell B
Publicado 2021

Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

por Coffman, Abigail A, Basta‐Pljakic, Jelena, Guerra, Rosa M, Ebetino, Frank H, Lundy, Mark W, Majeska, Robert J, Schaffler, Mitchell B
Publicado 2021

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

por Wang, Hua, Xiao, Lifeng, Tao, Jianguo, Srinivasan, Venkat, Boyce, Brendan F., Ebetino, Frank H., Oyajobi, Babatunde O., Boeckman, Robert K., Xing, Lianping
Publicado 2018

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

por Sugiyama, Toshihiro, Meakin, Lee B., Galea, Gabriel L., Jackson, Brendan F., Lanyon, Lance E., Ebetino, Frank H., Russell, R. Graham G., Price, Joanna S.
Publicado 2011

Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

por Okawa, Hiroko, Kondo, Takeru, Hokugo, Akishige, Cherian, Philip, Sundberg, Oskar, Campagna, Jesus J., Kashemirov, Boris A., John, Varghese, Sun, Shuting, Ebetino, Frank H., McKenna, Charles E., Nishimura, Ichiro
Publicado 2022

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase

por Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błażewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, Michael J., Coxon, Fraser P., Seabra, Miguel C.
Publicado 2009

Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. aureus Infection with Osseointegration in Murine Models of Implant-Associated...

por Xie, Chao, Ren, Youliang, Weeks, Jason, Xue, Thomas, Rainbolt, Joshua, Bentley, Karen de Mesy, Shu, Ye, Liu, Yuting, Masters, Elysia, Cherian, Philip, McKenna, Charles, Neighbors, Jeffrey, Ebetino, Frank, Schwarz, Edward, Sun, Shuting
Publicado 2023

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

por Munoz, Marcia A, Fletcher, Emma K, Skinner, Oliver P, Jurczyluk, Julie, Kristianto, Esther, Hodson, Mark P, Sun, Shuting, Ebetino, Frank H, Croucher, David R, Hansbro, Philip M, Center, Jacqueline R, Rogers, Michael J
Publicado 2021

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene dipho...

por Okawa, Hiroko, Kondo, Takeru, Hokugo, Akishige, Cherian, Philip, Campagna, Jesus J, Lentini, Nicholas A, Sung, Eric C, Chiang, Samantha, Lin, Yi-Ling, Ebetino, Frank H, John, Varghese, Sun, Shuting, McKenna, Charles E, Nishimura, Ichiro
Publicado 2022

Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicr...

por Sedghizadeh, Parish P., Cherian, Philip, Roshandel, Sahar, Tjokro, Natalia, Chen, Casey, Junka, Adam F., Hu, Eric, Neighbors, Jeffrey, Pawlak, Jacek, Russell, R. Graham G., McKenna, Charles E., Ebetino, Frank H., Sun, Shuting, Sodagar, Esmat
Publicado 2023

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi...

por Ren, Youliang, Xue, Thomas, Rainbolt, Joshua, Bentley, Karen L. de Mesy, Galloway, Chad A., Liu, Yuting, Cherian, Philip, Neighbors, Jeffrey, Hofstee, Marloes I., Ebetino, Frank H., Moriarty, Thomas Fintan, Sun, Shuting, Schwarz, Edward M., Xie, Chao
Publicado 2022

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated...

por Ren, Youliang, Weeks, Jason, Xue, Thomas, Rainbolt, Joshua, de Mesy Bentley, Karen L., Shu, Ye, Liu, Yuting, Masters, Elysia, Cherian, Philip, McKenna, Charles E., Neighbors, Jeffrey, Ebetino, Frank H., Schwarz, Edward M., Sun, Shuting, Xie, Chao
Publicado 2023

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using en...

por Tsoumpra, Maria K., Muniz, Joao R., Barnett, Bobby L., Kwaasi, Aaron A., Pilka, Ewa S., Kavanagh, Kathryn L., Evdokimov, Artem, Walter, Richard L., Von Delft, Frank, Ebetino, Frank H., Oppermann, Udo, Russell, R. Graham G., Dunford, James E.
Publicado 2015

Fluorescent Risedronate Analogues Reveal Bisphosphonate Uptake by Bone Marrow Monocytes and Localization Around Osteocytes In Vivo

por Roelofs, Anke J, Coxon, Fraser P, Ebetino, Frank H, Lundy, Mark W, Henneman, Zachary J, Nancollas, George H, Sun, Shuting, Blazewska, Katarzyna M, Bala, Joy Lynn F, Kashemirov, Boris A, Khalid, Aysha B, McKenna, Charles E, Rogers, Michael J
Publicado 2010

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

por Adjei-Sowah, Emmanuela, Peng, Yue, Weeks, Jason, Jonason, Jennifer H., de Mesy Bentley, Karen L., Masters, Elysia, Morita, Yugo, Muthukrishnan, Gowrishankar, Cherian, Philip, Hu, X. Eric, McKenna, Charles E., Ebetino, Frank H., Sun, Shuting, Schwarz, Edward M., Xie, Chao
Publicado 2021

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)

por Lawson, Michelle A, Ebetino, Frank H, Mazur, Adam, Chantry, Andrew D, Paton‐Hough, Julia, Evans, Holly R, Lath, Darren, Tsoumpra, Maria K, Lundy, Mark W, Dobson, Roy LM, Quijano, Michael, Kwaasi, Aaron A, Dunford, James E, Duan, Xuchen, Triffitt, James T, Jeans, Gwyn, Russell, R Graham G
Publicado 2017

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

por McDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R.G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M.W., Youlten, Scott E., Pettitt, Jessica A., Abi-Hanna, David, Jain, Rohit, Weninger, Wolfgang, Lundberg, Mischa, Sun, Shuting, Ebetino, Frank H., Timpson, Paul, Lee, Woei Ming, Baldock, Paul A., Rogers, Michael J., Brink, Robert, Williams, Graham R., Bassett, J.H. Duncan, Kemp, John P., Pavlos, Nathan J., Croucher, Peter I., Phan, Tri Giang
Publicado 2021

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

por McDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R.G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M.W., Youlten, Scott E., Pettitt, Jessica A., Abi-Hanna, David, Jain, Rohit, Weninger, Wolfgang, Lundberg, Mischa, Sun, Shuting, Ebetino, Frank H., Timpson, Paul, Lee, Woei Ming, Baldock, Paul A., Rogers, Michael J., Brink, Robert, Williams, Graham R., Bassett, J.H. Duncan, Kemp, John P., Pavlos, Nathan J., Croucher, Peter I., Phan, Tri Giang
Publicado 2021