Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

por Mazumder, Abhishek, Ebright, Richard H, Kapanidis, Achillefs N
Publicado 2021

Closing and opening of the RNA polymerase trigger loop

por Mazumder, Abhishek, Lin, Miaoxin, Kapanidis, Achillefs N., Ebright, Richard H.
Publicado 2020

Systematic Structure-Activity Analysis of Microcin J25

por Pavlova, Olga, Mukhopadhyay, Jayanta, Sineva, Elena, Ebright, Richard H., Severinov, Konstantin
Publicado 2008

RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding

por Mazumder, Abhishek, Wang, Anna, Uhm, Heesoo, Ebright, Richard H, Kapanidis, Achillefs N
Publicado 2021

Nonradioactive, ultrasensitive site-specific protein–protein photocrosslinking: interactions of α-helix 2 of TATA-binding protein with general transcription factor TFIIA and transc...

por Kim, Younggyu, Ebright, Yon W., Goodman, Adam R., Reinberg, Danny, Ebright, Richard H.
Publicado 2008

Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates

por Gabizon, Ronen, Lee, Antony, Vahedian-Movahed, Hanif, Ebright, Richard H., Bustamante, Carlos J.
Publicado 2018

The RNA polymerase clamp interconverts dynamically among three states and is stabilized in a partly closed state by ppGpp

por Duchi, Diego, Mazumder, Abhishek, Malinen, Anssi M, Ebright, Richard H, Kapanidis, Achillefs N
Publicado 2018

In transcription antitermination by Qλ, NusA induces refolding of Qλ to form a nozzle that extends the RNA polymerase RNA-exit channel

por Yin, Zhou, Bird, Jeremy G., Kaelber, Jason T., Nickels, Bryce E., Ebright, Richard H.
Publicado 2022

The mechanism of variability in transcription start site selection

por Yu, Libing, Winkelman, Jared T, Pukhrambam, Chirangini, Strick, Terence R, Nickels, Bryce E, Ebright, Richard H
Publicado 2017

Structural basis of ECF-σ-factor-dependent transcription initiation

por Lin, Wei, Mandal, Sukhendu, Degen, David, Cho, Min Sung, Feng, Yu, Das, Kalyan, Ebright, Richard H.
Publicado 2019

The Initiation Factor TFE and the Elongation Factor Spt4/5 Compete for the RNAP Clamp during Transcription Initiation and Elongation

por Grohmann, Dina, Nagy, Julia, Chakraborty, Anirban, Klose, Daniel, Fielden, Daniel, Ebright, Richard H., Michaelis, Jens, Werner, Finn
Publicado 2011

Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria

por Cheng, Andrew, Wan, Danny, Ghatak, Arkaprabha, Wang, Chengyuan, Feng, Deyu, Fondell, Joseph D., Ebright, Richard H., Fan, Huizhou
Publicado 2023

Structural and mechanistic basis of reiterative transcription initiation

por Liu, Yu, Yu, Libing, Pukhrambam, Chirangini, Winkelman, Jared T., Firlar, Emre, Kaelber, Jason T., Zhang, Yu, Nickels, Bryce E., Ebright, Richard H.
Publicado 2022

Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain

por Iorio, Marianna, Davatgarbenam, Sahar, Serina, Stefania, Criscenzo, Paolo, Zdouc, Mitja M., Simone, Matteo, Maffioli, Sonia I., Ebright, Richard H., Donadio, Stefano, Sosio, Margherita
Publicado 2021

Structural and mechanistic basis of σ-dependent transcriptional pausing

por Pukhrambam, Chirangini, Molodtsov, Vadim, Kooshkbaghi, Mahdi, Tareen, Ammar, Vu, Hoa, Skalenko, Kyle S., Su, Min, Yin, Zhou, Winkelman, Jared T., Kinney, Justin B., Ebright, Richard H., Nickels, Bryce E.
Publicado 2022

Highly efficient 5' capping of mitochondrial RNA with NAD(+) and NADH by yeast and human mitochondrial RNA polymerase

por Bird, Jeremy G, Basu, Urmimala, Kuster, David, Ramachandran, Aparna, Grudzien-Nogalska, Ewa, Towheed, Atif, Wallace, Douglas C, Kiledjian, Megerditch, Temiakov, Dmitry, Patel, Smita S, Ebright, Richard H, Nickels, Bryce E
Publicado 2018

Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance

por Lan, Tian, Ganapathy, Uday S., Sharma, Sachin, Ahn, Yong‐Mo, Zimmerman, Matthew, Molodtsov, Vadim, Hegde, Pooja, Gengenbacher, Martin, Ebright, Richard H., Dartois, Véronique, Freundlich, Joel S., Dick, Thomas, Aldrich, Courtney C.
Publicado 2022

Transcription inhibition by the depsipeptide antibiotic salinamide A

por Degen, David, Feng, Yu, Zhang, Yu, Ebright, Katherine Y, Ebright, Yon W, Gigliotti, Matthew, Vahedian-Movahed, Hanif, Mandal, Sukhendu, Talaue, Meliza, Connell, Nancy, Arnold, Eddy, Fenical, William, Ebright, Richard H
Publicado 2014

The mechanism of RNA 5′ capping with NAD(+), NADH, and desphospho-CoA

por Bird, Jeremy G., Zhang, Yu, Tian, Yuan, Panova, Natalya, Barvík, Ivan, Greene, Landon, Liu, Min, Buckley, Brian, Krásný, Libor, Lee, Jeehiun K., Kaplan, Craig D., Ebright, Richard H., Nickels, Bryce E.
Publicado 2016

An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

por van Helden, Jacques, Butler, Colin D, Achaz, Guillaume, Canard, Bruno, Casane, Didier, Claverie, Jean-Michel, Colombo, Fabien, Courtier, Virginie, Ebright, Richard H, Graner, François, Leitenberg, Milton, Morand, Serge, Petrovsky, Nikolai, Segreto, Rossana, Decroly, Etienne, Halloy, José
Publicado 2021