Monoclonal antibodies targeting cancer: 'magic bullets' or just the trigger?

por Eccles, Suzanne A
Publicado 2001

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

por Vinci, Maria, Box, Carol, Eccles, Suzanne A.
Publicado 2015

Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells

por Amornsupak, Kamolporn, Insawang, Tonkla, Thuwajit, Peti, O-Charoenrat, Pornchai, Eccles, Suzanne A, Thuwajit, Chanitra
Publicado 2014

HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells

por Amornsupak, Kamolporn, Thongchot, Suyanee, Thinyakul, Chanida, Box, Carol, Hedayat, Somaieh, Thuwajit, Peti, Eccles, Suzanne A., Thuwajit, Chanitra
Publicado 2022

Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI

por Boult, Jessica K.R., Box, Gary, Vinci, Maria, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, Robinson, Simon P.
Publicado 2017

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

por Powers, Marissa V, Valenti, Melanie, Miranda, Susana, Maloney, Alison, Eccles, Suzanne A., Thomas, George, Clarke, Paul A, Workman, Paul
Publicado 2013

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

por Vinci, Maria, Gowan, Sharon, Boxall, Frances, Patterson, Lisa, Zimmermann, Miriam, Court, William, Lomas, Cara, Mendiola, Marta, Hardisson, David, Eccles, Suzanne A
Publicado 2012

The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage

por Zaidi, Shane, McLaughlin, Martin, Bhide, Shreerang A., Eccles, Suzanne A., Workman, Paul, Nutting, Christopher M., Huddart, Robert A., Harrington, Kevin J.
Publicado 2012

Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd‐DTPA and USPIO‐enhanced imaging

por Boult, Jessica K.R., Borri, Marco, Jury, Alexa, Popov, Sergey, Box, Gary, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, Robinson, Simon P.
Publicado 2016

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

por Dart, Anna E., Box, Gary M., Court, William, Gale, Madeline E., Brown, John P., Pinder, Sarah E., Eccles, Suzanne A., Wells, Claire M.
Publicado 2015

Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro

por Burmi, Rajpal S., Box, Gary M., Wazir, Umar, Hussain, Haroon A., Davies, Julie A., Court, William J., Eccles, Suzanne A., Jiang, Wen G., Mokbel, Kefah, Harvey, Amanda J.
Publicado 2022

Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation

por Pal, Akos, Asad, Yasmin, Ruddle, Ruth, Henley, Alan T., Swales, Karen, Decordova, Shaun, Eccles, Suzanne A ., Collins, Ian, Garrett, Michelle D., De Bono, Johann, Banerji, Udai, Raynaud, Florence I.
Publicado 2020

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

por Miranda, Elena, Nordgren, Ida K., Male, Abigail L., Lawrence, Charlotte E., Hoakwie, Franciane, Cuda, Francesco, Court, William, Fox, Keith R., Townsend, Paul A., Packham, Graham K., Eccles, Suzanne A., Tavassoli, Ali
Publicado 2013

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library

por Welford, Amanda J, Caldwell, John J., Liu, Manjuan, Richards, Meirion, Brown, Nathan, Lomas, Cara, Tizzard, Graham J., Pitak, Mateusz B., Coles, Simon J., Eccles, Suzanne A., Raynaud, Florence I., Collins, Ian
Publicado 2016

Epigenetic disruption of cadherin-11 in human cancer metastasis

por Carmona, F Javier, Villanueva, Alberto, Vidal, August, Muñoz, Clara, Puertas, Sara, Penin, Rosa M, Gomà, Montserrat, Lujambio, Amaia, Piulats, Josep M, Mesía, Ricard, Sánchez-Céspedes, Montse, Manós, Manel, Condom, Enric, Eccles, Suzanne A, Esteller, Manel
Publicado 2012

Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma

por Baker, Lauren C. J., Sikka, Arti, Price, Jonathan M., Boult, Jessica K. R., Lepicard, Elise Y., Box, Gary, Jamin, Yann, Spinks, Terry J., Kramer-Marek, Gabriela, Leach, Martin O., Eccles, Suzanne A., Box, Carol, Robinson, Simon P.
Publicado 2018

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma

por Al-Saffar, Nada M. S., Troy, Helen, Wong Te Fong, Anne-Christine, Paravati, Roberta, Jackson, L. Elizabeth, Gowan, Sharon, Boult, Jessica K. R., Robinson, Simon P., Eccles, Suzanne A., Yap, Timothy A., Leach, Martin O., Chung, Yuen-Li
Publicado 2018

Selective FLT3 inhibition of FLT3-ITD(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

por Moore, Andrew S., Faisal, Amir, de Castro, David Gonzalez, Bavetsias, Vassilios, Sun, Chongbo, Atrash, Butrus, Valenti, Melanie, de Haven Brandon, Alexis, Avery, Sian, Mair, Debbie, Mirabella, Fabio, Swansbury, John, Pearson, Andrew D.J., Workman, Paul, Blagg, Julian, Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros
Publicado 2012

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

por McHardy, Tatiana, Caldwell, John J., Cheung, Kwai-Ming, Hunter, Lisa J., Taylor, Kevin, Rowlands, Martin, Ruddle, Ruth, Henley, Alan, de Haven Brandon, Alexis, Valenti, Melanie, Davies, Thomas G., Fazal, Lynsey, Seavers, Lisa, Raynaud, Florence I., Eccles, Suzanne A., Aherne, G. Wynne, Garrett, Michelle D., Collins, Ian
Publicado 2010

Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate fo...

por Bavetsias, Vassilios, Crumpler, Simon, Sun, Chongbo, Avery, Sian, Atrash, Butrus, Faisal, Amir, Moore, Andrew S., Kosmopoulou, Magda, Brown, Nathan, Sheldrake, Peter W., Bush, Katherine, Henley, Alan, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Raynaud, Florence I., Workman, Paul, Eccles, Suzanne A., Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian
Publicado 2012