Reinforcement Learning for Precision Oncology

por Eckardt, Jan-Niklas, Wendt, Karsten, Bornhäuser, Martin, Middeke, Jan Moritz
Publicado 2021

Semi-supervised learning in cancer diagnostics

por Eckardt, Jan-Niklas, Bornhäuser, Martin, Wendt, Karsten, Middeke, Jan Moritz
Publicado 2022

Deep learning detects acute myeloid leukemia and predicts NPM1 mutation status from bone marrow smears

por Eckardt, Jan-Niklas, Middeke, Jan Moritz, Riechert, Sebastian, Schmittmann, Tim, Sulaiman, Anas Shekh, Kramer, Michael, Sockel, Katja, Kroschinsky, Frank, Schuler, Ulrich, Schetelig, Johannes, Röllig, Christoph, Thiede, Christian, Wendt, Karsten, Bornhäuser, Martin
Publicado 2021

The future landscape of large language models in medicine

por Clusmann, Jan, Kolbinger, Fiona R., Muti, Hannah Sophie, Carrero, Zunamys I., Eckardt, Jan-Niklas, Laleh, Narmin Ghaffari, Löffler, Chiara Maria Lavinia, Schwarzkopf, Sophie-Caroline, Unger, Michaela, Veldhuizen, Gregory P., Wagner, Sophia J., Kather, Jakob Nikolas
Publicado 2023

Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears

por Eckardt, Jan-Niklas, Schmittmann, Tim, Riechert, Sebastian, Kramer, Michael, Sulaiman, Anas Shekh, Sockel, Katja, Kroschinsky, Frank, Schetelig, Johannes, Wagenführ, Lisa, Schuler, Ulrich, Platzbecker, Uwe, Thiede, Christian, Stölzel, Friedrich, Röllig, Christoph, Bornhäuser, Martin, Wendt, Karsten, Middeke, Jan Moritz
Publicado 2022

An overview and a roadmap for artificial intelligence in hematology and oncology

por Rösler, Wiebke, Altenbuchinger, Michael, Baeßler, Bettina, Beissbarth, Tim, Beutel, Gernot, Bock, Robert, von Bubnoff, Nikolas, Eckardt, Jan-Niklas, Foersch, Sebastian, Loeffler, Chiara M. L., Middeke, Jan Moritz, Mueller, Martha-Lena, Oellerich, Thomas, Risse, Benjamin, Scherag, André, Schliemann, Christoph, Scholz, Markus, Spang, Rainer, Thielscher, Christian, Tsoukakis, Ioannis, Kather, Jakob Nikolas
Publicado 2023

Unsupervised meta-clustering identifies risk clusters in acute myeloid leukemia based on clinical and genetic profiles

por Eckardt, Jan-Niklas, Röllig, Christoph, Metzeler, Klaus, Heisig, Peter, Stasik, Sebastian, Georgi, Julia-Annabell, Kroschinsky, Frank, Stölzel, Friedrich, Platzbecker, Uwe, Spiekermann, Karsten, Krug, Utz, Braess, Jan, Görlich, Dennis, Sauerland, Cristina, Woermann, Bernhard, Herold, Tobias, Hiddemann, Wolfgang, Müller-Tidow, Carsten, Serve, Hubert, Baldus, Claudia D., Schäfer-Eckart, Kerstin, Kaufmann, Martin, Krause, Stefan W., Hänel, Mathias, Berdel, Wolfgang E., Schliemann, Christoph, Mayer, Jiri, Hanoun, Maher, Schetelig, Johannes, Wendt, Karsten, Bornhäuser, Martin, Thiede, Christian, Middeke, Jan Moritz
Publicado 2023

Prediction of complete remission and survival in acute myeloid leukemia using supervised machine learning

por Eckardt, Jan-Niklas, Röllig, Christoph, Metzeler, Klaus, Kramer, Michael, Stasik, Sebastian, Georgi, Julia-Annabell, Heisig, Peter, Spiekermann, Karsten, Krug, Utz, Braess, Jan, Görlich, Dennis, Sauerland, Cristina M., Woermann, Bernhard, Herold, Tobias, Berdel, Wolfgang E., Hiddemann, Wolfgang, Kroschinsky, Frank, Schetelig, Johannes, Platzbecker, Uwe, Müller-Tidow, Carsten, Sauer, Tim, Serve, Hubert, Baldus, Claudia, Schäfer-Eckart, Kerstin, Kaufmann, Martin, Krause, Stefan, Hänel, Mathias, Schliemann, Christoph, Hanoun, Maher, Thiede, Christian, Bornhäuser, Martin, Wendt, Karsten, Middeke, Jan Moritz
Publicado 2022

UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome

por Georgi, Julia-Annabell, Stasik, Sebastian, Eckardt, Jan-Niklas, Zukunft, Sven, Hartwig, Marita, Röllig, Christoph, Middeke, Jan Moritz, Oelschlägel, Uta, Krug, Utz, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Kroschinsky, Frank, Thiede, Christian
Publicado 2023

Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome

por Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Cerqueira, Tiago, Kroschinsky, Frank, Berdel, Wolfgang E., Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Siepmann, Timo, Bornhäuser, Martin, Middeke, Jan Moritz, Thiede, Christian
Publicado 2023

Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia

por Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Petzold, Andreas, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Oelschlägel, Uta, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Dahl, Andreas, Schetelig, Johannes, Bornhäuser, Martin, Middeke, Jan Moritz, Thiede, Christian
Publicado 2023

Loss-of-Function Mutations of BCOR Are an Independent Marker of Adverse Outcomes in Intensively Treated Patients with Acute Myeloid Leukemia

por Eckardt, Jan-Niklas, Stasik, Sebastian, Kramer, Michael, Röllig, Christoph, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Rácil, Zdenek, Platzbecker, Uwe, Berdel, Wolfgang E., Mayer, Jiří, Serve, Hubert, Müller-Tidow, Carsten, Ehninger, Gerhard, Stölzel, Friedrich, Kroschinsky, Frank, Schetelig, Johannes, Bornhäuser, Martin, Thiede, Christian, Middeke, Jan Moritz
Publicado 2021

Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia – implications for the European LeukemiaNet risk classification

por Eckardt, Jan-Niklas, Bill, Marius, Rausch, Christian, Metzeler, Klaus, Spiekermann, Karsten, Stasik, Sebastian, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Krug, Utz, Wörmann, Bernhard, Hiddemann, Wolfgang, Görlich, Dennis, Sauerland, Cristina, Steffen, Björn, Einsele, Hermann, Neubauer, Andreas, Burchert, Andreas, Schäfer-Eckart, Kerstin, Berdel, Wolfgang E., Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Fransecky, Lars, Braess, Jan, Ruhnke, Leo, Schetelig, Johannes, Middeke, Jan Moritz, Serve, Hubert, Baldus, Claudia D., Platzbecker, Uwe, Müller-Tidow, Carsten, Bornhäuser, Martin, Herold, Tobias, Thiede, Christian, Röllig, Christoph
Publicado 2023

Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations

por Eckardt, Jan-Niklas, Stölzel, Friedrich, Kunadt, Desiree, Röllig, Christoph, Stasik, Sebastian, Wagenführ, Lisa, Jöhrens, Korinna, Kuithan, Friederike, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Kroschinsky, Frank, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Bornhäuser, Martin, Thiede, Christian, Middeke, Jan Moritz
Publicado 2022

S138: VALIDATION OF THE REVISED 2022 EUROPEAN LEUKEMIANET (ELN) RISK STRATIFICATION IN ADULT PATIENTS WITH ACUTE MYELOID LEUKEMIA

por Bill, Marius, Ruhnke, Leo, Zukunft, Sven, Schäfer, Silvia, Eckardt, Jan-Niklas, Stasik, Sebastian, Hanoun, Maher, Schroeder, Thomas, Fransecky, Lars, Steffen, Björn, Krause, Stefan W., Scholl, Sebastian, Hochhaus, Andreas, Sauer, Tim, Kraus, Sabrina, Schäfer-Eckart, Kerstin, Kaufmann, Martin, Jost, Edgar, Brümmendorf, Tim H, Schliemann, Christoph, Mikesch, Jan-Henrik, Krug, Utz, Hänel, Mathias, Morgner, Anke, Schaich, Markus, Neubauer, Andreas, Repp, Roland, Niemann, Dirk, Seggewiss-Bernhardt, Ruth, Meinhardt, Achim, Kullmer, Johannes, Kaiser, Ulrich, Blau, Wolfgang, Kiani, Alexander, Grigoleit, Götz Ulrich, Giagounidis, Aristoteles, Wurm, Alexander, Altmann, Heidi, Middeke, Jan Moritz, Schetelig, Johannes, Müller-Tidow, Carsten, Stölzel, Friedrich, Baldus, Claudia, Platzbecker, Uwe, Serve, Hubert, Bornhäuser, Martin, Thiede, Christian, Röllig, Christoph
Publicado 2023

Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study

por Middeke, Jan M., Metzeler, Klaus H., Röllig, Christoph, Krämer, Michael, Eckardt, Jan-Niklas, Stasik, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Kaufmann, Martin, Kunadt, Desiree, Wörmann, Bernhard, Sockel, Katja, von Bonin, Malte, Herold, Tobias, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Baldus, Claudia D., Ehninger, Gerhard, Schetelig, Johannes, Hiddemann, Wolfgang, Bornhäuser, Martin, Stölzel, Friedrich, Thiede, Christian
Publicado 2022