Macropinocytosis confers resistance to therapies targeting cancer anabolism

por Jayashankar, Vaishali, Edinger, Aimee L.
Publicado 2020

Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

por McCracken, Alison N., Edinger, Aimee L.
Publicado 2015

Rab7a activation promotes degradation of select tight junction proteins at the blood-brain barrier after ischemic stroke

por Cottarelli, Azzurra, Shahriar, Sanjid, Arac, Ahmet, Glendinning, Michael, Tuohy, Mary Claire, Prochilo, Grace, Neal, Jason B., Edinger, Aimee L., Agalliu, Dritan
Publicado 2023

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

por Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L
Publicado 2023

Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity

por Jayashankar, Vaishali, Selwan, Elizabeth, Hancock, Sarah E, Verlande, Amandine, Goodson, Maggie O, Eckenstein, Kazumi H, Milinkeviciute, Giedre, Hoover, Brianna M, Chen, Bin, Fleischman, Angela G, Cramer, Karina S, Hanessian, Stephen, Masri, Selma, Turner, Nigel, Edinger, Aimee L
Publicado 2021

Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation

por McCracken, Alison N., McMonigle, Ryan J., Tessier, Jérémie, Fransson, Rebecca, Perryman, Michael S., Chen, Bin, Keebaugh, Andrew, Selwan, Elizabeth, Barr, Sarah A., Kim, Seong M., Roy, Saurabh G., Liu, Gang, Fallegger, Daniel, Sernissi, Lorenzo, Brandt, Cordelia, Moitessier, Nicolas, Snider, Ashley J., Clare, Simon, Müschen, Markus, Huwiler, Andrea, Kleinman, Michael T., Hanessian, Stephen, Edinger, Aimee L.
Publicado 2016