Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate: Implications for Vaccine Efficacy Estimation and Sieve Analysis

por Edlefsen, Paul T.
Publicado 2014

Transposon identification using profile HMMs

por Edlefsen, Paul T, Liu, Jun S
Publicado 2010

Low Multiplicity of HIV-1 Infection and No Vaccine Enhancement in VAX003 Injection Drug Users

por Sterrett, Sarah, Learn, Gerald H., Edlefsen, Paul T., Haynes, Barton F., Hahn, Beatrice H., Shaw, George M., Bar, Katharine J.
Publicado 2014

SieveSifter: a web-based tool for visualizing the sieve analyses of HIV-1 vaccine efficacy trials

por Fiore-Gartland, Andrew, Kullman, Nicholas, deCamp, Allan C, Clenaghan, Graham, Yang, Wayne, Magaret, Craig A, Edlefsen, Paul T, Gilbert, Peter B
Publicado 2017

Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against Plasmodium Sporozoite Infection

por Vigdorovich, Vladimir, Patel, Hardik, Watson, Alexander, Raappana, Andrew, Reynolds, Laura, Selman, William, Beeman, Suzannah, Edlefsen, Paul T., Kappe, Stefan H. I., Sather, D. Noah
Publicado 2023

Observational study of effects of HIV Acquisition and Antiretroviral Treatment on Biomarkers of Systemic Immune Activation

por Kosmider, Ewelina, Wallner, Jackson, Gervassi, Ana, Ignacio, Rachel A Bender, Pinto-Santini, Delia, Gornalusse, German, Pandey, Urvashi, Hladik, Florian, Edlefsen, Paul T., Lama, Javier R., Duerr, Ann C., Frenkel, Lisa M.
Publicado 2023

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

por O’Connor, Megan A., Tisoncik-Go, Jennifer, Lewis, Thomas B., Miller, Charlene J., Bratt, Debra, Moats, Cassie R., Edlefsen, Paul T., Smedley, Jeremy, Klatt, Nichole R., Gale, Michael, Fuller, Deborah Heydenburg
Publicado 2018

No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy

por Edlefsen, Paul T., Birkmann, Alexander, Huang, Meei-Li, Magaret, Craig A., Kee, Jia Jin, Diem, Kurt, Goldner, Thomas, Timmler, Burkhard, Stoelben, Susanne, Ruebsamen-Schaeff, Helga, Zimmermann, Holger, Warren, Terri, Wald, Anna, Corey, Lawrence
Publicado 2016

Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features

por Magaret, Craig A., Benkeser, David C., Williamson, Brian D., Borate, Bhavesh R., Carpp, Lindsay N., Georgiev, Ivelin S., Setliff, Ian, Dingens, Adam S., Simon, Noah, Carone, Marco, Simpkins, Christopher, Montefiori, David, Alter, Galit, Yu, Wen-Han, Juraska, Michal, Edlefsen, Paul T., Karuna, Shelly, Mgodi, Nyaradzo M., Edugupanti, Srilatha, Gilbert, Peter B.
Publicado 2019

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

por Iwase, Saori C, Edlefsen, Paul T, Bhebhe, Lynnette, Motsumi, Kesego, Moyo, Sikhulile, Happel, Anna-Ursula, Shao, Danica, Mmasa, Nicholas, Schenkel, Sara, Gasper, Melanie A, Dubois, Melanie, Files, Megan A, Seshadri, Chetan, Duffy, Fergal, Aitchison, John, Netea, Mihai G, Jao, Jennifer, Cameron, Donald W, Gray, Clive M, Jaspan, Heather B, Powis, Kathleen M
Publicado 2023

Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge

por Hansen, Scott G., Womack, Jennie, Scholz, Isabel, Renner, Andrea, Edgel, Kimberly A., Xu, Guangwu, Ford, Julia C., Grey, Mikayla, St. Laurent, Brandyce, Turner, John M., Planer, Shannon, Legasse, Al W., Richie, Thomas L., Aguiar, Joao C., Axthelm, Michael K., Villasante, Eileen D., Weiss, Walter, Edlefsen, Paul T., Picker, Louis J., Früh, Klaus
Publicado 2019

A B cell follicle sanctuary permits persistent productive SIV infection in elite controllers

por Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A., Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I., Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W., Axthelm, Michael K., Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M., Edlefsen, Paul T., Piatak, Michael, Estes, Jacob D., Lifson, Jeffrey D., Picker, Louis J.
Publicado 2015

Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses

por Zolla-Pazner, Susan, Edlefsen, Paul T., Rolland, Morgane, Kong, Xiang-Peng, deCamp, Allan, Gottardo, Raphael, Williams, Constance, Tovanabutra, Sodsai, Sharpe-Cohen, Sandra, Mullins, James I., deSouza, Mark S., Karasavvas, Nicos, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Pitisuttihum, Punnee, Kaewkungwal, Jaranit, O'Connell, Robert J., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Gilbert, Peter
Publicado 2014

CD8 and CD4 Epitope Predictions in RV144: No Strong Evidence of a T-Cell Driven Sieve Effect in HIV-1 Breakthrough Sequences from Trial Participants

por Dommaraju, Kalpana, Kijak, Gustavo, Carlson, Jonathan M., Larsen, Brendan B., Tovanabutra, Sodsai, Geraghty, Dan E., Deng, Wenjie, Maust, Brandon S., Edlefsen, Paul T., Sanders-Buell, Eric, Ratto-Kim, Silvia, deSouza, Mark S., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Pitisuttihum, Punnee, Kaewkungwal, Jaranit, O'Connell, Robert J., Robb, Merlin L., Michael, Nelson L., Mullins, James I., Kim, Jerome H., Rolland, Morgane
Publicado 2014

Rapamycin limits CD4(+) T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy

por Varco-Merth, Benjamin D., Brantley, William, Marenco, Alejandra, Duell, Derick D., Fachko, Devin N., Richardson, Brian, Busman-Sahay, Kathleen, Shao, Danica, Flores, Walter, Engelman, Kathleen, Fukazawa, Yoshinori, Wong, Scott W., Skalsky, Rebecca L., Smedley, Jeremy, Axthelm, Michael K., Lifson, Jeffrey D., Estes, Jacob D., Edlefsen, Paul T., Picker, Louis J., Cameron, Cheryl M.A., Henrich, Timothy J., Okoye, Afam A.
Publicado 2022

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

por O’Connor, Megan A., Hawman, David W., Meade-White, Kimberly, Leventhal, Shanna, Song, Wenjun, Randall, Samantha, Archer, Jacob, Lewis, Thomas B., Brown, Brieann, Fredericks, Megan N., Sprouse, Kaitlin R., Tunggal, Hillary C., Maughan, Mara, Iwayama, Naoto, Ahrens, Chul, Garrison, William, Wangari, Solomon, Guerriero, Kathryn A., Hanley, Patrick, Lovaglio, Jamie, Saturday, Greg, Veesler, David, Edlefsen, Paul T., Khandhar, Amit P., Feldmann, Heinz, Fuller, Deborah Heydenburg, Erasmus, Jesse H.
Publicado 2023

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

por Fukazawa, Yoshinori, Park, Haesun, Cameron, Mark J., Lefebvre, Francois, Lum, Richard, Coombes, Noel, Mahyari, Eisa, Hagen, Shoko, Bae, Jin Young, Reyes, Marcelo Delos, Swanson, Tonya, Legasse, Alfred W., Sylwester, Andrew, Hansen, Scott G., Smith, Andrew T., Stafova, Petra, Shoemaker, Rebecca, Li, Yuan, Oswald, Kelli, Axthelm, Michael K., McDermott, Adrian, Ferrari, Guido, Montefiori, David C., Edlefsen, Paul T., Piatak, Michael, Lifson, Jeffrey D., Sékaly, Rafick P., Picker, Louis J.
Publicado 2012

Immune clearance of highly pathogenic SIV infection

por Hansen, Scott G., Piatak, Michael, Ventura, Abigail B., Hughes, Colette M., Gilbride, Roxanne M., Ford, Julia C., Oswald, Kelli, Shoemaker, Rebecca, Li, Yuan, Lewis, Matthew S., Gilliam, Awbrey N., Xu, Guangwu, Whizin, Nathan, Burwitz, Benjamin J., Planer, Shannon L., Turner, John M., Legasse, Alfred W., Axthelm, Michael K., Nelson, Jay A., Früh, Klaus, Sacha, Jonah B., Estes, Jacob D., Keele, Brandon F., Edlefsen, Paul T., Lifson, Jeffrey D., Picker, Louis J.
Publicado 2013

Combining Viral Genetics and Statistical Modeling to Improve HIV-1 Time-of-Infection Estimation towards Enhanced Vaccine Efficacy Assessment

por Rossenkhan, Raabya, Rolland, Morgane, Labuschagne, Jan P.L., Ferreira, Roux-Cil, Magaret, Craig A., Carpp, Lindsay N., Matsen IV, Frederick A., Huang, Yunda, Rudnicki, Erika E., Zhang, Yuanyuan, Ndabambi, Nonkululeko, Logan, Murray, Holzman, Ted, Abrahams, Melissa-Rose, Anthony, Colin, Tovanabutra, Sodsai, Warth, Christopher, Botha, Gordon, Matten, David, Nitayaphan, Sorachai, Kibuuka, Hannah, Sawe, Fred K., Chopera, Denis, Eller, Leigh Anne, Travers, Simon, Robb, Merlin L., Williamson, Carolyn, Gilbert, Peter B., Edlefsen, Paul T.
Publicado 2019

Molecular dating and viral load growth rates suggested that the eclipse phase lasted about a week in HIV-1 infected adults in East Africa and Thailand

por Rolland, Morgane, Tovanabutra, Sodsai, Dearlove, Bethany, Li, Yifan, Owen, Christopher L., Lewitus, Eric, Sanders-Buell, Eric, Bose, Meera, O’Sullivan, AnneMarie, Rossenkhan, Raabya, Labuschagne, Jan Phillipus Lourens, Edlefsen, Paul T., Reeves, Daniel B., Kijak, Gustavo, Miller, Shana, Poltavee, Kultida, Lee, Jenica, Bonar, Lydia, Harbolick, Elizabeth, Ahani, Bahar, Pham, Phuc, Kibuuka, Hannah, Maganga, Lucas, Nitayaphan, Sorachai, Sawe, Fred K., Eller, Leigh Anne, Gramzinski, Robert, Kim, Jerome H., Michael, Nelson L., Robb, Merlin L.
Publicado 2020