Drug-resistant Plasmodium falciparum: are recent advances a cause for optimism?

por Egan, Timothy J
Publicado 2015

Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter

por Egan, Timothy J, Kuter, David
Publicado 2013

Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition

por Ambele, Melvin A, Egan, Timothy J
Publicado 2012

Recent Advances in the Discovery of Haem-Targeting Drugs for Malaria and Schistosomiasis

por de Villiers, Katherine A., Egan, Timothy J.
Publicado 2009

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

por Amod, Leah, Mohunlal, Roxanne, Teixeira, Nicole, Egan, Timothy J., Wicht, Kathryn J.
Publicado 2023

Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites

por de Sousa, Ana Carolina C., Combrinck, Jill M., Maepa, Keletso, Egan, Timothy J.
Publicado 2020

Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites

por de Sousa, Ana Carolina C., Maepa, Keletso, Combrinck, Jill M., Egan, Timothy J.
Publicado 2020

Increase on the Initial Soluble Heme Levels in Acidic Conditions Is an Important Mechanism for Spontaneous Heme Crystallization In Vitro

por Stiebler, Renata, Hoang, Anh N., Egan, Timothy J., Wright, David W., Oliveira, Marcus F.
Publicado 2010

Effects of N-glycosylation of the human cation channel TRPA1 on agonist-sensitivity

por Egan, Timothy J., Acuña, Mario A., Zenobi-Wong, Marcy, Zeilhofer, Hanns Ulrich, Urech, David
Publicado 2016

Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments

por Egan, Timothy J., Diem, Dania, Weldon, Richard, Neumann, Tessa, Meyer, Sebastian, Urech, David M.
Publicado 2016

Arterial cannulation with ultrasound: clinical trial protocol for a randomised controlled trial comparing handheld ultrasound versus palpation technique for radial artery cannulati...

por Lan-Pak-Kee, Valerie, Ackland, Gareth L., Egan, Timothy C., Abbott, Tom EF., Elsheikh, Fatima
Publicado 2022

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

por Combrinck, Jill M., Fong, Kim Y., Gibhard, Liezl, Smith, Peter J., Wright, David W., Egan, Timothy J.
Publicado 2015

Unsaturated Glycerophospholipids Mediate Heme Crystallization: Biological Implications for Hemozoin Formation in the Kissing Bug Rhodnius prolixus

por Stiebler, Renata, Majerowicz, David, Knudsen, Jens, Gondim, Katia C., Wright, David W., Egan, Timothy J., Oliveira, Marcus F.
Publicado 2014

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity

por Sandlin, Rebecca D., Fong, Kim Y., Wicht, Kathryn J., Carrell, Holly M., Egan, Timothy J., Wright, David W.
Publicado 2014

Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

por Dambuza, Ntokozo S., Smith, Peter, Evans, Alicia, Norman, Jennifer, Taylor, Dale, Andayi, Andrew, Egan, Timothy, Chibale, Kelly, Wiesner, Lubbe
Publicado 2015

Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production

por Corbett, Yolanda, D’Alessandro, Sarah, Parapini, Silvia, Scaccabarozzi, Diletta, Kalantari, Parisa, Zava, Stefania, Giavarini, Flavio, Caruso, Donatella, Colombo, Irma, Egan, Timothy J., Basilico, Nicoletta
Publicado 2018

Reducing Baylisascaris procyonis Roundworm Larvae in Raccoon Latrines

por Page, Kristen, Beasley, James C., Olson, Zachary H., Smyser, Timothy J., Downey, Mark, Kellner, Kenneth F., McCord, Sarah E., Egan, Timothy S., Rhodes, Olin E.
Publicado 2011

Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

por Moyo, Phanankosi, Shamburger, William, van der Watt, Mariëtte E., Reader, Janette, de Sousa, Ana Carolina C., Egan, Timothy J., Maharaj, Vinesh J., Bringmann, Gerhard, Birkholtz, Lyn-Marie
Publicado 2020

Interference with Hemozoin Formation Represents an Important Mechanism of Schistosomicidal Action of Antimalarial Quinoline Methanols

por Corrêa Soares, Juliana B. R., Menezes, Diego, Vannier-Santos, Marcos A., Ferreira-Pereira, Antonio, Almeida, Giulliana T., Venancio, Thiago M., Verjovski-Almeida, Sergio, Zishiri, Vincent K., Kuter, David, Hunter, Roger, Egan, Timothy J., Oliveira, Marcus F.
Publicado 2009

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

por Dhingra, Satish K., Redhi, Devasha, Combrinck, Jill M., Yeo, Tomas, Okombo, John, Henrich, Philipp P., Cowell, Annie N., Gupta, Purva, Stegman, Matthew L., Hoke, Jonathan M., Cooper, Roland A., Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J., Fidock, David A.
Publicado 2017