Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

por Tang, Peifeng, Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Hoffman, Laurel, Du, Cheng, Song, Yuanli, Tao, Li, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Publicado 2020

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

por Tan, Zhijun, Ehamparanathan, Vivekh, Ren, Tingwei, Tang, Peifeng, Hoffman, Laurel, Kuang, June, Liu, Peiran, Huang, Chao, Du, Cheng, Tao, Li, Chemmalil, Letha, Lewandowski, Angela, Ghose, Sanchayita, Li, Zheng Jian, Liu, Shijie
Publicado 2020