Inhibitory receptors for HLA class I as immune checkpoints for natural killer cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

por Beelen, Nicky A., Ehlers, Femke A. I., Bos, Gerard M. J., Wieten, Lotte
Publicado 2022

Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity by Targeting Inhibitory Signaling via KIR and NKG2A

por Mahaweni, Niken M., Ehlers, Femke A. I., Bos, Gerard M. J., Wieten, Lotte
Publicado 2018

Activated Natural Killer Cells Withstand the Relatively Low Glucose Concentrations Found in the Bone Marrow of Multiple Myeloma Patients

por Ehlers, Femke A. I., Mahaweni, Niken M., Olieslagers, Timo I., Bos, Gerard M. J., Wieten, Lotte
Publicado 2021

Exploring the potential of combining IL-2-activated NK cells with an anti-PDL1 monoclonal antibody to target multiple myeloma-associated macrophages

por Ehlers, Femke A. I., Mahaweni, Niken M., van de Waterweg Berends, Annet, Saya, Thara, Bos, Gerard M. J., Wieten, Lotte
Publicado 2023

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

por Mahaweni, Niken M., Ehlers, Femke A. I., Sarkar, Subhashis, Janssen, Johanna W. H., Tilanus, Marcel G. J., Bos, Gerard M. J., Wieten, Lotte
Publicado 2018

Polymorphic differences within HLA‐C alleles contribute to alternatively spliced transcripts lacking exon 5

por Ehlers, Femke A. I., Olieslagers, Timo I., Groeneweg, Mathijs, Bos, Gerard M. J., Tilanus, Marcel G. J., Voorter, Christina E. M., Wieten, Lotte
Publicado 2022

ADCC-Inducing Antibody Trastuzumab and Selection of KIR-HLA Ligand Mismatched Donors Enhance the NK Cell Anti-Breast Cancer Response

por Ehlers, Femke A. I., Beelen, Nicky A., van Gelder, Michel, Evers, Tom M. J., Smidt, Marjolein L., Kooreman, Loes F. S., Bos, Gerard M. J., Wieten, Lotte
Publicado 2021

Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity

por Gong, Ying, Klein Wolterink, Roel G. J., Gulaia, Valeriia, Cloosen, Silvie, Ehlers, Femke A. I., Wieten, Lotte, Graus, Yvo F., Bos, Gerard M. J., Germeraad, Wilfred T. V.
Publicado 2021

NK cells in human visceral adipose tissue contribute to obesity‐associated insulin resistance through low‐grade inflammation

por Wouters, Kristiaan, Kusters, Yvo H.A.M., Bijnen, Mitchell, Wetzels, Suzan, Zhang, Xiaodi, Linssen, Pauline B.C., Gaens, Katrien, Houben, Alfons J.H.M., Joris, Peter J., Plat, Jogchum, Kooi, M. Eline, van der Kallen, Carla J.H., Mensink, Ronald P., Verboven, Kenneth, Jocken, Johan, Hansen, Dominique, Blaak, Ellen E., Ehlers, Femke A.I., Wieten, Lotte, Greve, Jan Willem, Rensen, Sander, Stehouwer, Coen D.A., Schalkwijk, Casper G.
Publicado 2020