Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis

por Ehrens, Alexandra, Hoerauf, Achim, Hübner, Marc P.
Publicado 2022

Eosinophils in filarial infections: Inducers of protection or pathology?

por Ehrens, Alexandra, Hoerauf, Achim, Hübner, Marc P.
Publicado 2022

Eosinophils and Neutrophils Eliminate Migrating Strongyloides ratti Larvae at the Site of Infection in the Context of Extracellular DNA Trap Formation

por Ehrens, Alexandra, Rüdiger, Nikolas, Heepmann, Lennart, Linnemann, Lara, Hartmann, Wiebke, Hübner, Marc P., Breloer, Minka
Publicado 2021

Corrigendum: Eosinophils and Neutrophils Eliminate Migrating Strongyloides ratti Larvae at the Site of Infection in the Context of Extracellular DNA Trap Formation

por Ehrens, Alexandra, Rüdiger, Nikolas, Heepmann, Lennart, Linnemann, Lara, Hartmann, Wiebke, Hübner, Marc P., Breloer, Minka
Publicado 2022

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

por Frohberger, Stefan J., Ajendra, Jesuthas, Surendar, Jayagopi, Stamminger, Wiebke, Ehrens, Alexandra, Buerfent, Benedikt C., Gentil, Katrin, Hoerauf, Achim, Hübner, Marc P.
Publicado 2019

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system

por Risch, Frederic, Scheunemann, Johanna F., Reichwald, Julia J., Lenz, Benjamin, Ehrens, Alexandra, Gal, Joséphine, Fercoq, Frédéric, Koschel, Marianne, Fendler, Martina, Hoerauf, Achim, Martin, Coralie, Hübner, Marc P.
Publicado 2023

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis

por Frohberger, Stefan J., Fercoq, Frederic, Neumann, Anna-Lena, Surendar, Jayagopi, Stamminger, Wiebke, Ehrens, Alexandra, Karunakaran, Indulekha, Remion, Estelle, Vogl, Thomas, Hoerauf, Achim, Martin, Coralie, Hübner, Marc P.
Publicado 2020

ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2(-/-) Mice

por Reichwald, Julia J., Risch, Frederic, Neumann, Anna-Lena, Frohberger, Stefan J., Scheunemann, Johanna F., Lenz, Benjamin, Ehrens, Alexandra, Strutz, Wiebke, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P.
Publicado 2022

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

por Hübner, Marc P., Ehrens, Alexandra, Koschel, Marianne, Dubben, Bettina, Lenz, Franziska, Frohberger, Stefan J., Specht, Sabine, Quirynen, Ludo, Lachau-Durand, Sophie, Tekle, Fetene, Baeten, Benny, Engelen, Marc, Mackenzie, Charles D., Hoerauf, Achim
Publicado 2019

Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus

por Rox, Katharina, Becker, Tim, Schiefer, Andrea, Grosse, Miriam, Ehrens, Alexandra, Jansen, Rolf, Aden, Tilman, Kehraus, Stefan, König, Gabriele M., Krome, Anna K., Hübner, Marc P., Wagner, Karl G., Stadler, Marc, Pfarr, Kenneth, Hoerauf, Achim
Publicado 2022

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

por Hübner, Marc P., Martin, Coralie, Specht, Sabine, Koschel, Marianne, Dubben, Bettina, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Struever, Dominique, Mitre, Edward, Vallarino-Lhermitte, Nathaly, Gokool, Suzanne, Lustigman, Sara, Schneider, Manfred, Townson, Simon, Hoerauf, Achim, Scandale, Ivan
Publicado 2020

In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

por Becker, Tim, Krome, Anna K., Vahdati, Sahel, Schiefer, Andrea, Pfarr, Kenneth, Ehrens, Alexandra, Aden, Tilman, Grosse, Miriam, Jansen, Rolf, Alt, Silke, Hesterkamp, Thomas, Stadler, Marc, Hübner, Marc P., Kehraus, Stefan, König, Gabriele M., Hoerauf, Achim, Wagner, Karl G.
Publicado 2022

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

por Hübner, Marc P., Koschel, Marianne, Struever, Dominique, Nikolov, Venelin, Frohberger, Stefan J., Ehrens, Alexandra, Fendler, Martina, Johannes, Iliana, von Geldern, Thomas W., Marsh, Kennan, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., Pfarr, Kenneth, Kempf, Dale J., Hoerauf, Achim
Publicado 2019

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

por Ehrens, Alexandra, Lunde, Christopher S., Jacobs, Robert T., Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J., Lenz, Franziska, Fendler, Martina, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J., Freund, Yvonne R., Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J., Hoerauf, Achim, Hübner, Marc P.
Publicado 2020

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections

por Schiefer, Andrea, Hübner, Marc P., Krome, Anna, Lämmer, Christine, Ehrens, Alexandra, Aden, Tilman, Koschel, Marianne, Neufeld, Helene, Chaverra-Muñoz, Lillibeth, Jansen, Rolf, Kehraus, Stefan, König, Gabriele M., Pogorevc, Domen, Müller, Rolf, Stadler, Marc, Hüttel, Stephan, Hesterkamp, Thomas, Wagner, Karl, Pfarr, Kenneth, Hoerauf, Achim
Publicado 2020

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections

por Hawryluk, Natalie, Robinson, Dale, Shen, Yixing, Kyne, Graham, Bedore, Matthew, Menon, Sanjay, Canan, Stacie, von Geldern, Thomas, Townson, Simon, Gokool, Suzanne, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Dalvie, Deepak, Specht, Sabine, Hübner, Marc Peter, Scandale, Ivan
Publicado 2022

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

por Hawryluk, Natalie, Zhiru, Li, Carlow, Clotilde, Gokool, Suzanne, Townson, Simon, Kreiss, Tamara, Chojnowski, Agnieszka, Prorok, Monika, Siekierka, John, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Canan, Stacie, Khetani, Vikram, Zeldis, Jerome, Specht, Sabine, Hübner, Marc P., Scandale, Ivan
Publicado 2022

The design and development of a study protocol to investigate Onchocerca volvulus, Loa loa and Mansonella perstans-mediated modulation of the metabolic and immunological profile in...

por Lenz, Benjamin, Andrew, Beng Amuam, Ritter, Manuel, Karunakaran, Indulekha, Gandjui, Narcisse Victor Tchamatchoua, Nchang, Lucy Cho, Surendar, Jayagopi, Ebob, Anita Obi Bate, Ehrens, Alexandra, Klarmann-Schulz, Ute, Ricchiuto, Arcangelo, Kuehlwein, Janina M., Fombad, Fanny Fri, Ngwa, Ambe Marius, Katcho, Tatiana Djikeussi, Hoerauf, Achim, Wanji, Samuel, Hübner, Marc P.
Publicado 2023

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

por von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Struever, Dominique, Frohberger, Stefan J., Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D., Hübner, Marc P., Hoerauf, Achim, Taylor, Mark J., Ward, Stephen A., Marsh, Kennan, Kempf, Dale J.
Publicado 2019

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

por Hübner, Marc P., Gunderson, Emma, Vogel, Ian, Bulman, Christina A., Lim, K.C., Koschel, Marianne, Ehrens, Alexandra, Frohberger, Stefan J., Fendler, Martina, Tricoche, Nancy, Voronin, Denis, Steven, Andrew, Chi, Victor, Bakowski, Malina A., Woods, Ashley K., Petrassi, H. Michael, McNamara, Case W., Beerntsen, Brenda, Chappell, Laura, Sullivan, William, Taylor, Mark J., Turner, Joseph D., Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A.
Publicado 2019