Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents

por Eisenmann, Eric D., Rorabaugh, Boyd R., Zoladz, Phillip R.
Publicado 2016

Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors

por Garrison, Dominique A., Talebi, Zahra, Eisenmann, Eric D., Sparreboom, Alex, Baker, Sharyn D.
Publicado 2020

Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B

por Garrison, Dominique A., Jin, Yan, Talebi, Zahra, Hu, Shuiying, Sparreboom, Alex, Baker, Sharyn D., Eisenmann, Eric D.
Publicado 2022

Exploring pharmacokinetics of talazoparib in ABCB1/ABCG2-deficient mice using a novel UHPLC-MS/MS method

por Talebi, Zahra, Garrison, Dominique A., Eisenmann, Eric D., Parmar, Kalindi, Shapiro, Geoffrey I., Rudek, Michelle A., Sparreboom, Alex, Jin, Yan
Publicado 2023

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

por Uddin, Muhammad Erfan, Garrison, Dominique A., Kim, Kyeongmin, Jin, Yan, Eisenmann, Eric D., Huang, Kevin M., Gibson, Alice A., Hu, Zeping, Sparreboom, Alex, Hu, Shuiying
Publicado 2021

Interaction of Antifungal Drugs with CYP3A- and OATP1B-Mediated Venetoclax Elimination

por Eisenmann, Eric D., Garrison, Dominique A., Talebi, Zahra, Jin, Yan, Silvaroli, Josie A., Kim, Jin-Gyu, Sparreboom, Alex, Savona, Michael R., Mims, Alice S., Baker, Sharyn D.
Publicado 2022

BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors

por Buelow, Daelynn R., Bhatnagar, Bhavana, Orwick, Shelley J., Jeon, Jae Yoon, Eisenmann, Eric D., Stromatt, Jack C., Pabla, Navjot Singh, Blachly, James S., Baker, Sharyn D., Blaser, Bradley W.
Publicado 2022

Intentional Modulation of Ibrutinib Pharmacokinetics through CYP3A Inhibition

por Eisenmann, Eric D., Fu, Qiang, Muhowski, Elizabeth M., Jin, Yan, Uddin, Muhammad Erfan, Garrison, Dominique A., Weber, Robert H., Woyach, Jennifer A., Byrd, John C., Sparreboom, Alex, Baker, Sharyn D.
Publicado 2021

A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug–Drug Interaction Liabilities

por Li, Yang, Jin, Yan, Taheri, Hanieh, Schmidt, Keith T., Gibson, Alice A., Buck, Stefan A. J., Eisenmann, Eric D., Mathijssen, Ron H. J., Figg, William D., Baker, Sharyn D., Sparreboom, Alex, Hu, Shuiying
Publicado 2022

TP-0903 Is Active in Preclinical Models of Acute Myeloid Leukemia with TP53 Mutation/Deletion

por Eisenmann, Eric D., Stromatt, Jack C., Fobare, Sydney, Huang, Kevin M., Buelow, Daelynn R., Orwick, Shelley, Jeon, Jae Yoon, Weber, Robert H., Larsen, Bill, Mims, Alice S., Hertlein, Erin, Byrd, John C., Baker, Sharyn D.
Publicado 2022

P512: A PHASE 1B/2 STUDY OF TP-0903 AND DECITABINE TARGETING MUTANT TP53 AND/OR COMPLEX KARYOTYPE IN PATIENTS WITH UNTREATED ACUTE MYELOID LEUKEMIA (AML) ≥ AGE 60 YEARS: FINAL RESU...

por Mims, Alice, Huang, Ying, Eisenmann, Eric, Orwick, Shelley, Buelow, Daelynn, Swords, Ronan, Zeidner, Joshua, Foster, Matthew, L. Lin, Tara, Baer, Maria, Madanat, Yazan, Kovacsovics, Tibor, Redner, Robert, Al-Mansour, Zeina, Stefanos, Mona, Martycz, Molly, Druggan, Franchesca, Chen, Timothy, Yocum, Ashley, Borate, Uma, Druker, Brian, Burd, Amy, Levine, Ross, Baker, Sharyn, C. Byrd, John
Publicado 2023

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

por Hussaarts, Koen G. A. M., van Doorn, Leni, Eechoute, Karel, Damman, Jeffrey, Fu, Qiang, van Doorn, Nadia, Eisenmann, Eric D., Gibson, Alice A., Oomen-de Hoop, Esther, de Bruijn, Peter, Baker, Sharyn D., Koolen, Stijn L. W., van Gelder, Teun, van Leeuwen, Roelof W. F., Mathijssen, Ron H. J., Sparreboom, Alex, Bins, Sander
Publicado 2020

TP-0903 is active in models of drug-resistant acute myeloid leukemia

por Jeon, Jae Yoon, Buelow, Daelynn R., Garrison, Dominique A., Niu, Mingshan, Eisenmann, Eric D., Huang, Kevin M., Zavorka Thomas, Megan E., Weber, Robert H., Whatcott, Clifford J., Warner, Steve L., Orwick, Shelley J., Carmichael, Bridget, Stahl, Emily, Brinton, Lindsey T., Lapalombella, Rosa, Blachly, James S., Hertlein, Erin, Byrd, John C., Bhatnagar, Bhavana, Baker, Sharyn D.
Publicado 2020

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia

por Uddin, Muhammad Erfan, Eisenmann, Eric D., Li, Yang, Huang, Kevin M., Garrison, Dominique A., Talebi, Zahra, Gibson, Alice A., Jin, Yan, Nepal, Mahesh, Bonilla, Ingrid M., Fu, Qiang, Sun, Xinxin, Millar, Alec, Tarasov, Mikhail, Jay, Christopher E., Cui, Xiaoming, Einolf, Heidi J., Pelis, Ryan M., Smith, Sakima A., Radwański, Przemysław B., Sweet, Douglas H., König, Jörg, Fromm, Martin F., Carnes, Cynthia A., Hu, Shuiying, Sparreboom, Alex
Publicado 2022