Catching a DUB in the act: novel ubiquitin-based active site directed probes

por Ekkebus, Reggy, Flierman, Dennis, Geurink, Paul P, Ovaa, Huib
Publicado 2014

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

por Sahtoe, Danny D., van Dijk, Willem J., Ekkebus, Reggy, Ovaa, Huib, Sixma, Titia K.
Publicado 2016

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

por Sahtoe, Danny D., van Dijk, Willem J., El Oualid, Farid, Ekkebus, Reggy, Ovaa, Huib, Sixma, Titia K.
Publicado 2015

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

por Békés, Miklós, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Ovaa, Huib, Huang, Tony T., Lima, Christopher D.
Publicado 2016

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin**

por El Oualid, Farid, Merkx, Remco, Ekkebus, Reggy, Hameed, Dharjath S, Smit, Judith J, de Jong, Annemieke, Hilkmann, Henk, Sixma, Titia K, Ovaa, Huib
Publicado 2010

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

por Flierman, Dennis, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Geurink, Paul P., Mevissen, Tycho E.T., Hospenthal, Manuela K., Komander, David, Ovaa, Huib
Publicado 2016

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

por Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Publicado 2013

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

por Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Publicado 2019

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

por Mevissen, Tycho E.T., Hospenthal, Manuela K., Geurink, Paul P., Elliott, Paul R., Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M.V., Ovaa, Huib, Komander, David
Publicado 2013

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

por van Welsem, Tibor, Korthout, Tessy, Ekkebus, Reggy, Morais, Dominique, Molenaar, Thom M, van Harten, Kirsten, Poramba-Liyanage, Deepani W, Sun, Su Ming, Lenstra, Tineke L, Srivas, Rohith, Ideker, Trey, Holstege, Frank C P, van Attikum, Haico, El Oualid, Farid, Ovaa, Huib, Stulemeijer, Iris J E, Vlaming, Hanneke, van Leeuwen, Fred
Publicado 2018