Precision Medicine and Sickle Cell Disease

por El Hoss, Sara, El Nemer, Wassim, Rees, David C.
Publicado 2022

High Affinity Binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM Adhesion Glycoprotein

por Reppin, Franziska, Cochet, Sylvie, El Nemer, Wassim, Fritz, Günter, Schmidt, Gudula
Publicado 2017

Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients

por Wang, Jue, Hertz, Laura, Ruppenthal, Sandra, El Nemer, Wassim, Connes, Philippe, Goede, Jeroen S., Bogdanova, Anna, Birnbaumer, Lutz, Kaestner, Lars
Publicado 2021

Characterization of red blood cell microcirculatory parameters using a bioimpedance microfluidic device

por Xu, Tieying, Lizarralde-Iragorri, Maria A., Roman, Jean, Ghasemi, Rasta, Lefèvre, Jean-Pierre, Martincic, Emile, Brousse, Valentine, Français, Olivier, El Nemer, Wassim, Le Pioufle, Bruno
Publicado 2020

ABCG2 Is Overexpressed on Red Blood Cells in Ph-Negative Myeloproliferative Neoplasms and Potentiates Ruxolitinib-Induced Apoptosis

por Buks, Ralfs, Brusson, Mégane, Cochet, Sylvie, Galochkina, Tatiana, Cassinat, Bruno, Nemazanyy, Ivan, Peyrard, Thierry, Kiladjian, Jean-Jacques, de Brevern, Alexandre G., Azouzi, Slim, El Nemer, Wassim
Publicado 2021

Red blood cell proteomics reveal remnant protein biosynthesis and folding pathways in PIEZO1-related hereditary xerocytosis

por Caulier, Alexis, Jankovsky, Nicolas, Gautier, Emilie Fleur, El Nemer, Wassim, Guitton, Corinne, Ouled-Haddou, Hakim, Guillonneau, François, Mayeux, Patrick, Salnot, Virginie, Bruce, Johanna, Picard, Véronique, Garçon, Loïc
Publicado 2022

Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology

por Brousse, Valentine, Colin, Yves, Pereira, Catia, Arnaud, Cecile, Odièvre, Marie Helene, Boutemy, Anne, Guitton, Corinne, de Montalembert, Mariane, Lapouméroulie, Claudine, Picot, Julien, Le Van Kim, Caroline, El Nemer, Wassim
Publicado 2014

The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease

por Koehl, Bérengère, Nivoit, Pierre, El Nemer, Wassim, Lenoir, Olivia, Hermand, Patricia, Pereira, Catia, Brousse, Valentine, Guyonnet, Léa, Ghinatti, Giulia, Benkerrou, Malika, Colin, Yves, Le Van Kim, Caroline, Tharaux, Pierre-Louis
Publicado 2017

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease

por El Hoss, Sara, Cochet, Sylvie, Godard, Auria, Yan, Hongxia, Dussiot, Michaël, Frati, Giacomo, Boutonnat-Faucher, Bénédicte, Laurance, Sandrine, Renaud, Olivier, Joseph, Laure, Miccio, Annarita, Brousse, Valentine, Mohandas, Narla, El Nemer, Wassim
Publicado 2020

Altered Ca(2+) Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

por Buks, Ralfs, Dagher, Tracy, Rotordam, Maria Giustina, Monedero Alonso, David, Cochet, Sylvie, Gautier, Emilie-Fleur, Chafey, Philippe, Cassinat, Bruno, Kiladjian, Jean-Jacques, Becker, Nadine, Plo, Isabelle, Egée, Stéphane, El Nemer, Wassim
Publicado 2021

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera

por Brusson, Mégane, De Grandis, Maria, Cochet, Sylvie, Bigot, Sylvain, Marin, Mickaël, Leduc, Marjorie, Guillonneau, François, Mayeux, Patrick, Peyrard, Thierry, Chomienne, Christine, Le Van Kim, Caroline, Cassinat, Bruno, Kiladjian, Jean-Jacques, El Nemer, Wassim
Publicado 2018

An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype

por Weber, Leslie, Poletti, Valentina, Magrin, Elisa, Antoniani, Chiara, Martin, Samia, Bayard, Charles, Sadek, Hanem, Felix, Tristan, Meneghini, Vasco, Antoniou, Michael N., El-Nemer, Wassim, Mavilio, Fulvio, Cavazzana, Marina, Andre-Schmutz, Isabelle, Miccio, Annarita
Publicado 2018

Oxidative stress activates red cell adhesion to laminin in sickle cell disease

por Lizarralde-Iragorri, Maria Alejandra, Lefevre, Sophie D., Cochet, Sylvie, El Hoss, Sara, Brousse, Valentine, Filipe, Anne, Dussiot, Michael, Azouzi, Slim, Le Van Kim, Caroline, Rodrigues-Lima, Fernando, Français, Olivier, Le Pioufle, Bruno, Klei, Thomas, van Bruggen, Robin, El Nemer, Wassim
Publicado 2020

Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype

por Weber, Leslie, Frati, Giacomo, Felix, Tristan, Hardouin, Giulia, Casini, Antonio, Wollenschlaeger, Clara, Meneghini, Vasco, Masson, Cecile, De Cian, Anne, Chalumeau, Anne, Mavilio, Fulvio, Amendola, Mario, Andre-Schmutz, Isabelle, Cereseto, Anna, El Nemer, Wassim, Concordet, Jean-Paul, Giovannangeli, Carine, Cavazzana, Marina, Miccio, Annarita
Publicado 2020

In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell–Related Injury

por Federti, Enrica, Matte, Alessandro, Recchiuti, Antonio, Garello, Francesca, Ghigo, Alessandra, El Nemer, Wassim, Terreno, Enzo, Amoresano, Angela, Mattoscio, Domenico, Turrini, Franco, Lebouef, Christophe, Janin, Anne, Pantaleo, Antonella, Russo, Roberta, Marin, Mickael, Iatcencko, Iana, Riccardi, Veronica, Siciliano, Angela, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia
Publicado 2023

Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

por Antoniou, Panagiotis, Hardouin, Giulia, Martinucci, Pierre, Frati, Giacomo, Felix, Tristan, Chalumeau, Anne, Fontana, Letizia, Martin, Jeanne, Masson, Cecile, Brusson, Megane, Maule, Giulia, Rosello, Marion, Giovannangeli, Carine, Abramowski, Vincent, de Villartay, Jean-Pierre, Concordet, Jean-Paul, Del Bene, Filippo, El Nemer, Wassim, Amendola, Mario, Cavazzana, Marina, Cereseto, Anna, Romano, Oriana, Miccio, Annarita
Publicado 2022