Tissue-Specific Delivery of CRISPR Therapeutics: Strategies and Mechanisms of Non-Viral Vectors

por Shalaby, Karim, Aouida, Mustapha, El-Agnaf, Omar
Publicado 2020

Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline

por Ehtewish, Hanan, Arredouani, Abdelilah, El-Agnaf, Omar
Publicado 2022

Gene-Based Therapeutics for Parkinson’s Disease

por Shalaby, Karim E., El-Agnaf, Omar M. A.
Publicado 2022

Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification

por Mesleh, Areej G., Abdulla, Sara A., El-Agnaf, Omar
Publicado 2021

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

por Bérard, Morgan, Martínez-Drudis, Laura, Sheta, Razan, El-Agnaf, Omar M. A., Oueslati, Abid
Publicado 2023

Rapid Assessment of CRISPR Transfection Efficiency and Enrichment of CRISPR Induced Mutations Using a Dual-Fluorescent Stable Reporter System

por Shalaby, Karim E., Aouida, Mustapha, Gupta, Vijay, Ghanem, Simona S., El-Agnaf, Omar M. A.
Publicado 2022

Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage

por Majbour, Nour, Aasly, Jan, Abdi, Ilham, Ghanem, Simona, Erskine, Daniel, van de Berg, Wilma, El-Agnaf, Omar
Publicado 2022

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

por Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda, Kirik, Deniz
Publicado 2016

Decrease in Plasma Levels of α-Synuclein Is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference

por Ishii, Ryotaro, Tokuda, Takahiko, Tatebe, Harutsugu, Ohmichi, Takuma, Kasai, Takashi, Nakagawa, Masanori, Mizuno, Toshiki, El-Agnaf, Omar M. A.
Publicado 2015

A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid(42) and DJ-1 in Human Cerebrospinal Fluid

por Kruse, Niels, Schlossmacher, Michael G., Schulz-Schaeffer, Walter J., Vanmechelen, Eugeen, Vanderstichele, Hugo, El-Agnaf, Omar M., Mollenhauer, Brit
Publicado 2016

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

por Poggiolini, Ilaria, Erskine, Daniel, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, Morris, Christopher M., El-Agnaf, Omar M. A.
Publicado 2021

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers

por Vaikath, Nishant, Sudhakaran, Indulekha, Abdi, Ilham, Gupta, Vijay, Majbour, Nour, Ghanem, Simona, Abdesselem, Houari, Vekrellis, Kostas, El-Agnaf, Omar
Publicado 2022

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

por Ghanem, Simona S., Fayed, Hend S., Zhu, Qi, Lu, Jia-Hong, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, El-Agnaf, Omar M. A.
Publicado 2021

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies

por Gupta, Vijay, Sudhakaran, Indulekha P., Islam, Zeyaul, Vaikath, Nishant N., Hmila, Issam, Lukacsovich, Tamas, Kolatkar, Prasanna R., El-Agnaf, Omar M. A.
Publicado 2020

Cerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders

por Constantinides, Vasilios C., Majbour, Nour K., Paraskevas, George P., Abdi, Ilham, Safieh-Garabedian, Bared, Stefanis, Leonidas, El-Agnaf, Omar M., Kapaki, Elisabeth
Publicado 2021

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

por Karampetsou, Mantia, Ardah, Mustafa T., Semitekolou, Maria, Polissidis, Alexia, Samiotaki, Martina, Kalomoiri, Maria, Majbour, Nour, Xanthou, Georgina, El-Agnaf, Omar M. A., Vekrellis, Kostas
Publicado 2017

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies

por Hatton, Christopher, Reeve, Amy, Lax, Nichola Zoe, Blain, Alasdair, Ng, Yi Shiau, El-Agnaf, Omar, Attems, Johannes, Taylor, John-Paul, Turnbull, Doug, Erskine, Daniel
Publicado 2020

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease

por Majbour, Nour K., Chiasserini, Davide, Vaikath, Nishant N., Eusebi, Paolo, Tokuda, Takahiko, van de Berg, Wilma, Parnetti, Lucilla, Calabresi, Paolo, El-Agnaf , Omar M. A.
Publicado 2017

Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein

por Abdi, Ilham Y., Majbour, Nour K., Willemse, Eline A. J., van de Berg, Wilma D. J., Mollenhauer, Brit, Teunissen, Charlotte E., El-Agnaf, Omar M.
Publicado 2021

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

por Murakami, Hidetomo, Tokuda, Takahiko, El-Agnaf, Omar M. A., Ohmichi, Takuma, Miki, Ayako, Ohashi, Hideaki, Owan, Yoshiyuki, Saito, Yu, Yano, Satoshi, Tsukie, Tamao, Ikeuchi, Takeshi, Ono, Kenjiro
Publicado 2019