Gene-Based Therapeutics for Parkinson’s Disease

por Shalaby, Karim E., El-Agnaf, Omar M. A.
Publicado 2022

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

por Bérard, Morgan, Martínez-Drudis, Laura, Sheta, Razan, El-Agnaf, Omar M. A., Oueslati, Abid
Publicado 2023

Rapid Assessment of CRISPR Transfection Efficiency and Enrichment of CRISPR Induced Mutations Using a Dual-Fluorescent Stable Reporter System

por Shalaby, Karim E., Aouida, Mustapha, Gupta, Vijay, Ghanem, Simona S., El-Agnaf, Omar M. A.
Publicado 2022

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein

por Landeck, Natalie, Hall, Hélène, Ardah, Mustafa T., Majbour, Nour K., El-Agnaf, Omar M. A., Halliday, Glenda, Kirik, Deniz
Publicado 2016

Decrease in Plasma Levels of α-Synuclein Is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference

por Ishii, Ryotaro, Tokuda, Takahiko, Tatebe, Harutsugu, Ohmichi, Takuma, Kasai, Takashi, Nakagawa, Masanori, Mizuno, Toshiki, El-Agnaf, Omar M. A.
Publicado 2015

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

por Poggiolini, Ilaria, Erskine, Daniel, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, Morris, Christopher M., El-Agnaf, Omar M. A.
Publicado 2021

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

por Ghanem, Simona S., Fayed, Hend S., Zhu, Qi, Lu, Jia-Hong, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, El-Agnaf, Omar M. A.
Publicado 2021

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies

por Gupta, Vijay, Sudhakaran, Indulekha P., Islam, Zeyaul, Vaikath, Nishant N., Hmila, Issam, Lukacsovich, Tamas, Kolatkar, Prasanna R., El-Agnaf, Omar M. A.
Publicado 2020

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

por Karampetsou, Mantia, Ardah, Mustafa T., Semitekolou, Maria, Polissidis, Alexia, Samiotaki, Martina, Kalomoiri, Maria, Majbour, Nour, Xanthou, Georgina, El-Agnaf, Omar M. A., Vekrellis, Kostas
Publicado 2017

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease

por Majbour, Nour K., Chiasserini, Davide, Vaikath, Nishant N., Eusebi, Paolo, Tokuda, Takahiko, van de Berg, Wilma, Parnetti, Lucilla, Calabresi, Paolo, El-Agnaf , Omar M. A.
Publicado 2017

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

por Murakami, Hidetomo, Tokuda, Takahiko, El-Agnaf, Omar M. A., Ohmichi, Takuma, Miki, Ayako, Ohashi, Hideaki, Owan, Yoshiyuki, Saito, Yu, Yano, Satoshi, Tsukie, Tamao, Ikeuchi, Takeshi, Ono, Kenjiro
Publicado 2019

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain

por Cronin, Kenneth D., Ge, Dongliang, Manninger, Paul, Linnertz, Colton, Rossoshek, Anna, Orrison, Bonnie M., Bernard, David J., El-Agnaf, Omar M.A., Schlossmacher, Michael G., Nussbaum, Robert L., Chiba-Falek, Ornit
Publicado 2009

Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism?

por Sakaue, Satoshi, Kasai, Takashi, Mizuta, Ikuko, Suematsu, Masaya, Osone, Shinya, Azuma, Yumiko, Imamura, Toshihiko, Tokuda, Takahiko, Kanno, Hitoshi, El-Agnaf, Omar M. A., Morimoto, Masafumi, Nakagawa, Masanori, Hosoi, Hajime, Mizuno, Toshiki
Publicado 2017

Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases

por Fayyad, Muneera, Erskine, Daniel, Majbour, Nour K., Vaikath, Nishant N., Ghanem, Simona S., Sudhakaran, Indulekha P., Abdesselem, Houari, Lamprokostopoulou, Agaristi, Vekrellis, Kostas, Morris, Christopher M., Attems, Johannes, El‐Agnaf, Omar M. A.
Publicado 2020

α-Synuclein Levels in Blood Plasma from LRRK2 Mutation Carriers

por Gorostidi, Ana, Bergareche, Alberto, Ruiz-Martínez, Javier, Martí-Massó, José F., Cruz, María, Varghese, Shiji, Qureshi, Mohamed M., Alzahmi, Fatimah, Al-Hayani, Abdulmonem, de Munáin, Adolfo López, El-Agnaf, Omar M.A.
Publicado 2012

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

por Ardah, Mustafa T., Ghanem, Simona S., Abdulla, Sara A., Lv, Guohua, Emara, Mohamed M., Paleologou, Katerina E., Vaikath, Nishant N., Lu, Jia-Hong, Li, Min, Vekrellis, Konstantinos, Eliezer, David, El-Agnaf, Omar M. A.
Publicado 2020

Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity

por Ardah, Mustafa T., Paleologou, Katerina E., Lv, Guohua, Abul Khair, Salema B., Kazim, Abdulla S., Minhas, Saeed T., Al-Tel, Taleb H., Al-Hayani, Abdulmonem A., Haque, Mohammed E., Eliezer, David, El-Agnaf, Omar M. A.
Publicado 2014

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers

por Aasly, Jan O., Johansen, Krisztina K., Brønstad, Gunnar, Warø, Bjørg J., Majbour, Nour K., Varghese, Shiji, Alzahmi, Fatimah, Paleologou, Katerina E., Amer, Dena A. M., Al-Hayani, Abdulmonem, El-Agnaf, Omar M. A.
Publicado 2014

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies

por van Steenoven, Inger, Majbour, Nour K., Vaikath, Nishant N., Berendse, Henk W., van der Flier, Wiesje M., van de Berg, Wilma D.J., Teunissen, Charlotte E., Lemstra, Afina W., El‐Agnaf, Omar M.A.
Publicado 2018

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

por Majbour, Nour K., Aasly, Jan O., Hustad, Eldbjørg, Thomas, Mercy A., Vaikath, Nishant N., Elkum, Naser, van de Berg, Wilma D. J., Tokuda, Takahiko, Mollenhauer, Brit, Berendse, Henk W., El-Agnaf, Omar M. A.
Publicado 2020