Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis

por Halaby, Marie-Jo, Hakem, Anne, Li, Li, El Ghamrasni, Samah, Venkatesan, Shriram, Hande, Prakash M., Sanchez, Otto, Hakem, Razqallah
Publicado 2013

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

por Li, Li, Halaby, Marie-Jo, Hakem, Anne, Cardoso, Renato, El Ghamrasni, Samah, Harding, Shane, Chan, Norman, Bristow, Robert, Sanchez, Otto, Durocher, Daniel, Hakem, Razqallah
Publicado 2010

Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer

por El Ghamrasni, Samah, Pamidi, Ashwin, Halaby, Marie Jo, Bohgaki, Miyuki, Cardoso, Renato, Li, Li, Venkatesan, Shriram, Sethu, Swaminathan, Hirao, Atsushi, Mak, Tak W., Hande, Manoor Prakash, Hakem, Anne, Hakem, Razqallah
Publicado 2011

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

por Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah
Publicado 2016

Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer

por El Ghamrasni, Samah, Quevedo, Rene, Hawley, James, Mazrooei, Parisa, Hanna, Youstina, Cirlan, Iulia, Zhu, Helen, Bruce, Jeff P., Oldfield, Leslie E., Yang, S.Y. Cindy, Guilhamon, Paul, Reimand, Jüri, Cescon, Dave W., Done, Susan J., Lupien, Mathieu, Pugh, Trevor J.
Publicado 2022

Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor

por Quevedo, Rene, Spreafico, Anna, Bruce, Jeff, Danesh, Arnavaz, El Ghamrasni, Samah, Giesler, Amanda, Hanna, Youstina, Have, Cherry, Li, Tiantian, Yang, S. Y. Cindy, Zhang, Tong, Asa, Sylvia L., Haibe-Kains, Benjamin, Krzyzanowska, Monika, Smith, Adam C., Singh, Simron, Siu, Lillian L., Pugh, Trevor J.
Publicado 2020

The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor–resistant ER(+) breast cancer with mitotic aberrations

por Soria-Bretones, Isabel, Thu, Kelsie L., Silvester, Jennifer, Cruickshank, Jennifer, El Ghamrasni, Samah, Ba-alawi, Wail, Fletcher, Graham C., Kiarash, Reza, Elliott, Mitchell J., Chalmers, Jordan J., Elia, Andrea C., Cheng, Albert, Rose, April A. N., Bray, Mark R., Haibe-Kains, Benjamin, Mak, Tak W., Cescon, David W.
Publicado 2022

Systemic ceramide accumulation leads to severe and varied pathological consequences

por Alayoubi, Abdulfatah M, Wang, James C M, Au, Bryan C Y, Carpentier, Stéphane, Garcia, Virginie, Dworski, Shaalee, El-Ghamrasni, Samah, Kirouac, Kevin N, Exertier, Mathilde J, Xiong, Zi Jian, Privé, Gilbert G, Simonaro, Calogera M, Casas, Josefina, Fabrias, Gemma, Schuchman, Edward H, Turner, Patricia V, Hakem, Razqallah, Levade, Thierry, Medin, Jeffrey A
Publicado 2013

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

por Cindy Yang, S. Y., Lien, Scott C., Wang, Ben X., Clouthier, Derek L., Hanna, Youstina, Cirlan, Iulia, Zhu, Kelsey, Bruce, Jeffrey P., El Ghamrasni, Samah, Iafolla, Marco A. J., Oliva, Marc, Hansen, Aaron R., Spreafico, Anna, Bedard, Philippe L., Lheureux, Stephanie, Razak, Albiruni, Speers, Vanessa, Berman, Hal K., Aleshin, Alexey, Haibe-Kains, Benjamin, Brooks, David G., McGaha, Tracy L., Butler, Marcus O., Bratman, Scott V., Ohashi, Pamela S., Siu, Lillian L., Pugh, Trevor J.
Publicado 2021

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

por Krishnan, Rehna, Lapierre, Mariah, Gautreau, Brandon, Nixon, Kevin C J, El Ghamrasni, Samah, Patel, Parasvi S, Hao, Jun, Yerlici, V Talya, Guturi, Kiran Kumar Naidu, St-Germain, Jonathan, Mateo, Francesca, Saad, Amine, Algouneh, Arash, Earnshaw, Rebecca, Shili, Duan, Seitova, Alma, Miller, Joshua, Khosraviani, Negin, Penn, Adam, Ho, Brandon, Sanchez, Otto, Hande, M Prakash, Masson, Jean-Yves, Brown, Grant W, Alaoui-Jamali, Moulay, Reynolds, John J, Arrowsmith, Cheryl, Raught, Brian, Pujana, Miguel A, Mekhail, Karim, Stewart, Grant S, Hakem, Anne, Hakem, Razqallah
Publicado 2023

Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

por Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., Lo, Kwok-Wai
Publicado 2021

Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

por Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., Lo, Kwok-Wai
Publicado 2022