Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors

por El-Miligy, Mostafa M. M., Al-Kubeisi, Ahmed K., Bekhit, Mohamed G., El-Zemity, Saad R., Nassra, Rasha A., Hazzaa, Aly A.
Publicado 2022

Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs

por El-Dershaby, Nada H., El-Hawash, Soad A., Kassab, Shaymaa E., Daabees, Hoda G., Abdel Moneim, Ahmed E., El-Miligy, Mostafa M. M.
Publicado 2022

Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities

por El-Miligy, Mostafa M. M., Abdelaziz, Marwa E., Fahmy, Salwa M., Ibrahim, Tamer M., Abu-Serie, Marwa M., Mahran, Mona A., Hazzaa, Aly A.
Publicado 2023

Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

por El-Dershaby, Nada H., El-Hawash, Soad A., Kassab, Shaymaa E., Dabees, Hoda G., Abdel Moneim, Ahmed E., Abdel Wahab, Ibrahim A., Abd-Alhaseeb, Mohammad M., El-Miligy, Mostafa M. M.
Publicado 2022