Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models

por Hoch, Ute, Staschen, Carl-Michael, Johnson, Randall K., Eldon, Michael A.
Publicado 2014

Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration

por Sy, S. Kenneth, Sweeney, Theresa D., Ji, Chunmei, Hoch, Ute, Eldon, Michael A.
Publicado 2016

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors

por Sy, Sherwin K. B., Chia, Yen Lin, Gordi, Toufigh, Hoch, Ute, Eldon, Michael A.
Publicado 2018

Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects

por Eldon, Michael A., Parsley, Edwin L., Maurer, Mari, Tarara, Thomas E., Okikawa, Jerry, Weers, Jeffry G.
Publicado 2021

Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone

por Webster, Lynn, Henningfield, Jack, Buchhalter, August R, Siddhanti, Suresh, Lu, Lin, Odinecs, Aleksandrs, Di Fonzo, Carlo J, Eldon, Michael A
Publicado 2018

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer

por Adkins, Chris E., Nounou, Mohamed I., Hye, Tanvirul, Mohammad, Afroz S., Terrell-Hall, Tori, Mohan, Neel K., Eldon, Michael A., Hoch, Ute, Lockman, Paul R.
Publicado 2015