Fragment screening of cyclin G-associated kinase by weak affinity chromatography

por Meiby, Elinor, Knapp, Stefan, Elkins, Jonathan M., Ohlson, Sten
Publicado 2012

Crystal Structure of Human Aurora B in Complex with INCENP and VX-680

por Elkins, Jonathan M., Santaguida, Stefano, Musacchio, Andrea, Knapp, Stefan
Publicado 2012

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis

por Sorrell, Fiona J., Kilian, Lena Marie, Elkins, Jonathan M.
Publicado 2019

Crystal structure of human RIOK2 bound to a specific inhibitor

por Wang, Jing, Varin, Thibault, Vieth, Michal, Elkins, Jonathan M.
Publicado 2019

Analysis of conditions affecting auto-phosphorylation of human kinases during expression in bacteria

por Shrestha, Amit, Hamilton, Garth, O’Neill, Eric, Knapp, Stefan, Elkins, Jonathan M.
Publicado 2012

Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class

por Salah, Eidarus, Ugochukwu, Emilie, Barr, Alastair J., von Delft, Frank, Knapp, Stefan, Elkins, Jonathan M.
Publicado 2011

Structural insights into the activation of MST3 by MO25

por Mehellou, Youcef, Alessi, Dario R., Macartney, Thomas J., Szklarz, Marta, Knapp, Stefan, Elkins, Jonathan M.
Publicado 2013

The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex

por Abdul Azeez, Kamal R., Knapp, Stefan, Fernandes, João M. P., Klussmann, Enno, Elkins, Jonathan M.
Publicado 2014

Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors

por de Toledo, Ian, Grigolo, Thiago A., Bennett, James M., Elkins, Jonathan M., Pilli, Ronaldo A.
Publicado 2019

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

por Homan, Kristoff T., Larimore, Kelly M., Elkins, Jonathan M., Szklarz, Marta, Knapp, Stefan, Tesmer, John J. G.
Publicado 2014

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

por Dixon-Clarke, Sarah E., Elkins, Jonathan M., Cheng, S.-W. Grace, Morin, Gregg B., Bullock, Alex N.
Publicado 2015

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

por Abdul Azeez, Kamal R., Chatterjee, Sneha, Yu, Channing, Golub, Todd R., Sobott, Frank, Elkins, Jonathan M.
Publicado 2019

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer

por Scott, Fiona, Fala, Angela M., Pennicott, Lewis E., Reuillon, Tristan D., Massirer, Katlin B., Elkins, Jonathan M., Ward, Simon E.
Publicado 2020

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

por Santiago, André da Silva, Couñago, Rafael M., Ramos, Priscila Zonzini, Godoi, Paulo H. C., Massirer, Katlin B., Gileadi, Opher, Elkins, Jonathan M.
Publicado 2018

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity

por Righetto, Germanna Lima, Sriranganadane, Dev, Halabelian, Levon, Chiodi, Carla G., Elkins, Jonathan M., Massirer, Katlin B., Gileadi, Opher, Menossi, Marcelo, Couñago, Rafael M.
Publicado 2019

Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

por Sansook, Supojjanee, Ocasio, Cory A., Day, Iain J., Tizzard, Graham J., Coles, Simon J., Fedorov, Oleg, Bennett, James M., Elkins, Jonathan M., Spencer, John
Publicado 2017

Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

por Sansook, Supojjanee, Ocasio, Cory A., Day, Iain J., Tizzard, Graham J., Coles, Simon J., Fedorov, Oleg, Bennett, James M., Elkins, Jonathan M., Spencer, John
Publicado 2017

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

por Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.
Publicado 2013

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

por Elkins, Jonathan M., Wang, Jing, Deng, Xianming, Pattison, Michael J., Arthur, J. Simon C., Erazo, Tatiana, Gomez, Nestor, Lizcano, Jose M., Gray, Nathanael S., Knapp, Stefan
Publicado 2013

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

por Asquith, Christopher R. M., Bennett, James M., Su, Lianyong, Laitinen, Tuomo, Elkins, Jonathan M., Pickett, Julie E., Wells, Carrow I., Li, Zengbiao, Willson, Timothy M., Zuercher, William J.
Publicado 2019