Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33

por Azoitei, Ninel, Hoffmann, Christopher M., Ellegast, Jana M., Ball, Claudia R., Obermayer, Kerstin, Gößele, Ulrike, Koch, Britta, Faber, Katrin, Genze, Felicitas, Schrader, Mark, Kestler, Hans A., Döhner, Hartmut, Chiosis, Gabriela, Glimm, Hanno, Fröhling, Stefan, Scholl, Claudia
Publicado 2012

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

por Harada, Taku, Kalfon, Jérémie, Perez, Monika W., Eagle, Kenneth, Braes, Flora Dievenich, Batley, Rashad, Heshmati, Yaser, Ferrucio, Juliana Xavier, Ewers, Jazmin, Mehta, Stuti, Kossenkov, Andrew, Ellegast, Jana M., Bowker, Allyson, Wickramasinghe, Jayamanna, Nabet, Behnam, Paralkar, Vikram R., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Publicado 2023

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

por Lu, Diana Y., Ellegast, Jana M., Ross, Kenneth N., Malone, Clare F., Lin, Shan, Mabe, Nathaniel W., Dharia, Neekesh V., Meyer, Ashleigh, Conway, Amy, Su, Angela H., Selich-Anderson, Julia, Taslim, Cenny, Byrum, Andrea K., Seong, Bo Kyung A., Adane, Biniam, Gray, Nathanael S., Rivera, Miguel N., Lessnick, Stephen L., Stegmaier, Kimberly
Publicado 2023

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

por Harada, Taku, Heshmati, Yaser, Kalfon, Jérémie, Perez, Monika W., Xavier Ferrucio, Juliana, Ewers, Jazmin, Hubbell Engler, Benjamin, Kossenkov, Andrew, Ellegast, Jana M., Yi, Joanna S., Bowker, Allyson, Zhu, Qian, Eagle, Kenneth, Liu, Tianxin, Kai, Yan, Dempster, Joshua M., Kugener, Guillaume, Wickramasinghe, Jayamanna, Herbert, Zachary T., Li, Charles H., Vrabič Koren, Jošt, Weinstock, David M., Paralkar, Vikram R., Nabet, Behnam, Lin, Charles Y., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Publicado 2022