Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

por Zhang, Ningzhe, An, Mahru C., Montoro, Daniel, Ellerby, Lisa M.
Publicado 2010

Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease

por Naphade, Swati, Embusch, Alexander, Madushani, Kuruwitage Lakshika, Ring, Karen L., Ellerby, Lisa M.
Publicado 2018

Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast

por Longo, Valter D., Ellerby, Lisa M., Bredesen, Dale E., Valentine, Joan S., Gralla, Edith B.
Publicado 1997

Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model

por Duncan, Carlotta E, An, Mahru C, Papanikolaou, Theodora, Rugani, Caitlin, Vitelli, Cathy, Ellerby, Lisa M
Publicado 2013

Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease

por Schurman, Charles A., Burton, Jordan B., Rose, Jacob, Ellerby, Lisa M., Alliston, Tamara, Schilling, Birgit
Publicado 2023

PNA microprobe for label-free detection of expanded trinucleotide repeats

por Asefifeyzabadi, Narges, Durocher, Grace, Tshilenge, Kizito-Tshitoko, Alam, Tanimul, Ellerby, Lisa M., Shamsi, Mohtashim H.
Publicado 2022

Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System

por An, Mahru C., O'Brien, Robert N., Zhang, Ningzhe, Patra, Biranchi N., De La Cruz, Michael, Ray, Animesh, Ellerby, Lisa M.
Publicado 2014

N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties

por Scott, Gary K., Mahoney, Sophia, Scott, Madeleine, Loureiro, Ashley, Lopez-Ramirez, Alejandro, Tanner, John J., Ellerby, Lisa M., Benz, Christopher C.
Publicado 2021

Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D(1) Receptor Signaling

por Cirnaru, Maria-Daniela, Melis, Chiara, Fanutza, Tomas, Naphade, Swati, Tshilenge, Kizito-Tshitoko, Muntean, Brian S., Martemyanov, Kirill A., Plotkin, Joshua L., Ellerby, Lisa M., Ehrlich, Michelle E.
Publicado 2019

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

por Ring, Karen L., An, Mahru C., Zhang, Ningzhe, O’Brien, Robert N., Ramos, Eliana Marisa, Gao, Fuying, Atwood, Robert, Bailus, Barbara J., Melov, Simon, Mooney, Sean D., Coppola, Giovanni, Ellerby, Lisa M.
Publicado 2015

Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease

por Song, Sicheng, Creus Muncunill, Jordi, Galicia Aguirre, Carlos, Tshilenge, Kizito-Tshitoko, Hamilton, B. Wade, Gerencser, Akos A., Benlhabib, Houda, Cirnaru, Maria-Daniela, Leid, Mark, Mooney, Sean D., Ellerby, Lisa M., Ehrlich, Michelle E.
Publicado 2022

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease

por Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Zhang, Ningzhe, Vodicka, Petr, Alexander, Jonathan, Aviolat, Hubert, Gatune, Leah, Reeves, Patrick, Li, Xueyi, Khvorova, Anastasia, Ellerby, Lisa M., Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Publicado 2019

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

por Gao, Rui, Chakraborty, Anirban, Geater, Charlene, Pradhan, Subrata, Gordon, Kara L, Snowden, Jeffrey, Yuan, Subo, Dickey, Audrey S, Choudhary, Sanjeev, Ashizawa, Tetsuo, Ellerby, Lisa M, La Spada, Albert R, Thompson, Leslie M, Hazra, Tapas K, Sarkar, Partha S
Publicado 2019

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

por Miller, John P., Yates, Bridget E., Al-Ramahi, Ismael, Berman, Ari E., Sanhueza, Mario, Kim, Eugene, de Haro, Maria, DeGiacomo, Francesco, Torcassi, Cameron, Holcomb, Jennifer, Gafni, Juliette, Mooney, Sean D., Botas, Juan, Ellerby, Lisa M., Hughes, Robert E.
Publicado 2012

FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16(INK4a) increase

por Voisin, Jessica, Farina, Francesca, Naphade, Swati, Fontaine, Morgane, Tshilenge, Kizito‐Tshitoko, Galicia Aguirre, Carlos, Lopez‐Ramirez, Alejandro, Dancourt, Julia, Ginisty, Aurélie, Sasidharan Nair, Satish, Lakshika Madushani, Kuruwitage, Zhang, Ningzhe, Lejeune, François‐Xavier, Verny, Marc, Campisi, Judith, Ellerby, Lisa M., Neri, Christian
Publicado 2020

Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

por Tshilenge, Kizito-Tshitoko, Aguirre, Carlos Galicia, Bons, Joanna, Gerencser, Akos A., Basisty, Nathan, Song, Sicheng, Rose, Jacob, Lopez-Ramirez, Alejandro, Naphade, Swati, Loureiro, Ashley, Battistoni, Elena, Milani, Mateus, Wehrfritz, Cameron, Holtz, Anja, Hetz, Claudio, Mooney, Sean D., Schilling, Birgit, Ellerby, Lisa M.
Publicado 2023

Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction

por Bar, Sudipta, Wilson, Kenneth A., Hilsabeck, Tyler A.U., Alderfer, Sydney, Dammer, Eric B., Burton, Jordan B, Shah, Samah, Holtz, Anja, Carrera, Enrique M., Beck, Jennifer N., Chen, Jackson H, Kauwe, Grant, Tracy, Tara E., Seyfried, Nicholas T., Schilling, Birgit, Ellerby, Lisa M., Kapahi, Pankaj
Publicado 2023

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

por Sorek, Matan, Oweis, Walaa, Nissim-Rafinia, Malka, Maman, Moria, Simon, Shahar, Hession, Cynthia C., Adiconis, Xian, Simmons, Sean K., Sanjana, Neville E., Shi, Xi, Lu, Congyi, Pan, Jen Q., Xu, Xiaohong, Pouladi, Mahmoud A., Ellerby, Lisa M., Zhang, Feng, Levin, Joshua Z., Meshorer, Eran
Publicado 2021

Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

por Cirnaru, Maria-Daniela, Song, Sicheng, Tshilenge, Kizito-Tshitoko, Corwin, Chuhyon, Mleczko, Justyna, Galicia Aguirre, Carlos, Benlhabib, Houda, Bendl, Jaroslav, Apontes, Pasha, Fullard, John, Creus-Muncunill, Jordi, Reyahi, Azadeh, Nik, Ali M, Carlsson, Peter, Roussos, Panos, Mooney, Sean D, Ellerby, Lisa M, Ehrlich, Michelle E
Publicado 2021

Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels

por Bailus, Barbara J., Scheeler, Stephen M., Simons, Jesse, Sanchez, Maria A., Tshilenge, Kizito-Tshitoko, Creus-Muncunill, Jordi, Naphade, Swati, Lopez-Ramirez, Alejandro, Zhang, Ningzhe, Lakshika Madushani, Kuruwitage, Moroz, Stanislav, Loureiro, Ashley, Schreiber, Katherine H., Hausch, Felix, Kennedy, Brian K., Ehrlich, Michelle E., Ellerby, Lisa M.
Publicado 2021